Patents by Inventor David A. Hogsett
David A. Hogsett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11873520Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.Type: GrantFiled: September 30, 2021Date of Patent: January 16, 2024Assignee: Lallemand Hungary Liquidity Management LLCInventors: William Ryan Sillers, Shital A. Tripathi, Arthur J. Shaw, IV, Aaron Argyros, David A. Hogsett
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Publication number: 20220267816Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.Type: ApplicationFiled: September 30, 2021Publication date: August 25, 2022Inventors: William Ryan Sillers, Shital A. Tripathi, Arthur J. Shaw, IV, Aaron Argyros, David A. Hogsett
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Patent number: 11162125Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.Type: GrantFiled: October 22, 2018Date of Patent: November 2, 2021Assignee: Lallemand Hungary Liquidity Management LLCInventors: William Ryan Sillers, Shital A. Tripathi, Arthur J. Shaw, IV, Aaron Argyros, David A. Hogsett
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Publication number: 20200270657Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.Type: ApplicationFiled: October 22, 2018Publication date: August 27, 2020Inventors: William Ryan Sillers, Shital A. Tripathi, Arthur J. Shaw, IV, Aaron Argyros, David A. Hogsett
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Patent number: 10494654Abstract: A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic mutation that enables the cell to produce at least one fatty acid and/or acyl coenzyme A (CoA) thereof by increased enzymatic activity in the cell relative to the wild type cell of malonyl-CoA dependent and malonyl-ACP independent fatty acyl-CoA metabolic pathway, wherein the fatty acid contains at least 5 carbon atoms; and (ii) a second genetic mutation that increases the activity of at least one wax ester synthase in the cell relative to the wild type cell and the wax ester synthase has sequence identity of at least 50% to a polypeptide of SEQ ID NO: 1-8 and combinations thereof or to a functional fragment of any of the polypeptides for catalyzing the conversion of fatty acid and/or acyl coenzyme A thereof to the fatty acid ester.Type: GrantFiled: March 12, 2018Date of Patent: December 3, 2019Assignee: CARGILL, INCORPORATEDInventors: Katrin Grammann, Jan Wolter, Liv Reinecke, Steffen Schaffer, Eileen E. Spindler, Wendy K. Ribble, Brittany L. Robinson, Catherine B. Poor, Tanya Warnecke Lipscomb, Hans H. Liao, David A. Hogsett, Ronald J. Evans
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Patent number: 10138504Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.Type: GrantFiled: August 5, 2011Date of Patent: November 27, 2018Assignee: Lallemand Hungary Liquidity Management LLCInventors: William Ryan Sillers, Shital A. Tripathi, Arthur J. Shaw, IV, Aaron Argyros, David A. Hogsett
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Patent number: 9605269Abstract: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.Type: GrantFiled: May 5, 2011Date of Patent: March 28, 2017Assignee: Lallemand Hungary Liquidity Management LLCInventors: William Ryan Sillers, Hans Van Dijken, Steve Licht, Arthur J. Shaw, IV, Alan Benjamin Gilbert, Aaron Argyros, Allan C. Froehlich, John E. McBride, Haowen Xu, David A. Hogsett, Vineet B. Rajgarhia
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Patent number: 9315833Abstract: The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.Type: GrantFiled: February 18, 2010Date of Patent: April 19, 2016Assignees: Lallemand Hungary Liquidity Management LLC, Stellenbosch UniversityInventors: John McBride, Mark Mellon, Vineet Rajgarhia, Elena E. Brevnova, Erin Wiswall, David A. Hogsett, Danie LaGrange, Shaunita Rose, Emile Van Zyl
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Publication number: 20130323766Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.Type: ApplicationFiled: August 5, 2011Publication date: December 5, 2013Applicant: Mascoma CorporationInventors: William Ryan Sillers, Shital A. Tripathi, Arthur J. Shaw, Aaron Argyros, David A. Hogsett
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Publication number: 20130302870Abstract: A new and improved biomass conversion system is disclosed using high-temperature flow-though pretreatment and a nanoporous membrane to provide more digestible biomass for subsequent conversion to biofuels.Type: ApplicationFiled: June 20, 2011Publication date: November 14, 2013Applicant: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Lee R. Lynd, Chaogong Liu, David A. Hogsett
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Publication number: 20130273555Abstract: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.Type: ApplicationFiled: May 5, 2011Publication date: October 17, 2013Applicant: Mascoma CorporationInventors: William Ryan Sillers, Hans Van Dijken, Steve Licht, Arthur J. Shaw, IV, Alan Benjamin Gilbert, Aaron Argyros, Allan C. Froehlich, John E. McBride, Haowen Xu, David A. Hogsett, Vineet B. Rajgarhia
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Publication number: 20120142046Abstract: The present invention relates to the engineering and expression of heterologous cellulosomes in microorganisms in order to facilitate the conversion of biomass to useful products. In some embodiments, the invention relates to the expression of scaffoldin proteins which form the nucleus of a cellulosome. Cellulases or other biomass-degrading enzymes can be non-covalently linked to the scaffoldin protein by virtue of a dockerin domain-cohesin domain interaction.Type: ApplicationFiled: February 18, 2010Publication date: June 7, 2012Inventors: John McBride, Mark Mellon, Vineet Rajgarhia, Elena E. Brevnova, Erin Wiswall, David A. Hogsett, Danie LaGrange, Shaunita Rose, Emile Van Zyl
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Publication number: 20120108798Abstract: The present invention is directed to a process of producing substantially pure lignin from lignocellulosic biomass, which comprises: pre-treating a lignocellulosic feedstock to produce a reactive lignin-carbohydrate mixture; biologically-reacting the carbohydrates in the mixture, separating remaining solids from the liquid fermentation products, and drying the resulting solids to yield a substantially pure lignin product. Optionally, the lignin product may be washed and subjected to a second hydrolysis step. Optionally, the lignin product may be further processed by hydrotreating and/or pyrolysis in order to yield desirable products such as fuel additives.Type: ApplicationFiled: October 16, 2009Publication date: May 3, 2012Applicant: Mascoma CorporationInventors: Kevin S. Wenger, David A. Hogsett, Michael Ladisch, John Basdsley
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Publication number: 20120094343Abstract: One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.Type: ApplicationFiled: November 12, 2009Publication date: April 19, 2012Applicant: Mascoma CorporationInventors: David A. Hogsett, Vineet Rajgarhia, Arthur J. Shaw, IV, Nicky C. Caiazza
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Publication number: 20110256601Abstract: Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced hydrogenase activities. One such mutant strain with both the ldh and hydtrA genes inactivated shows a significant increase in ethanol production. Manipulation of hydrogenase activities provides a new approach for enhancing substrate utilization and ethanol production by biomass-fermenting microorganisms.Type: ApplicationFiled: December 17, 2008Publication date: October 20, 2011Applicant: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Arthur Josephus Shaw, IV, Lee Lynd, David A. Hogsett
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Patent number: 5258293Abstract: An improved and highly productive method of continuously producing ethanol from lignocellulosic substrates is provided. The method involves providing a suitable microbial system within a reaction vessel and adding fermentable substrate to the reactor to form a reaction mixture. The fermentation reaction is allowed to proceed while a quiescent state is maintained within the reactor. During the fermentation, soluble substrate is differentially retained relative to the feed slurry and reaction biocatalysts are retained and internally recycled within the system. Further, while fermenting substrate is retained within the system, it forms a stratified zone within the reactor such that the concentration of actively fermenting substrate is highest at upper portions of the reaction zone and is lowest, near zero, at a lower portion of the reaction zone. Insoluble, fully reacted substrate may be withdrawn from a region near the bottom of the reactor.Type: GrantFiled: May 3, 1991Date of Patent: November 2, 1993Assignee: Trustees of Dartmouth CollegeInventors: Lee R. Lynd, David A. Hogsett, Gisbert Spieles