Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Abstract: A formula, apparatus and method of manufacturing a confectionery with an ornamental shape is disclosed. The invention comprises a jacket dough capable of being formed into an ornamental shape, said jacket dough further comprising flour; a leavening system; an oil, water and emulsifier system; sweeteners; flavoring additives; and coloring additives.

Abstract: A system for performing a standard penetration test, including a hammer assembly with a hammer and a hammer lifting device, an elevator assembly for raising and lowering the hammer assembly, a hammer sensor for sensing a position of the hammer within the hammer assembly, and an elevator sensor for sensing a position of the hammer assembly relative to the elevator assembly. A method for performing a standard penetration test, including positioning a hammer assembly at a hammer assembly ready position, sensing with an elevator sensor a reference position of a hammer assembly relative to the elevator assembly, sensing with a hammer sensor a zero position of a hammer, lifting the hammer with a hammer lifting device from the zero position to a drop position of the hammer, sensing with the hammer sensor the drop position, and dropping the hammer onto an anvil.

Abstract: A method for producing an ultrasonic transducer or ultrasonic transducer array, the method comprising providing or depositing a layer of piezoelectric material on a substrate. The piezoelectric material is a doped, co-deposited or alloyed piezoelectric material. The piezoelectric material comprises: a doped, co-deposited or alloyed metal oxide or metal nitride, the metal oxide or metal nitride being doped, co-deposited or alloyed with vanadium or a compound thereof; or zinc oxide doped, co-deposited or alloyed with a transition metal or a compound thereof. Optionally, the deposition of the layer of piezoelectric material is by sputter coating, e.g. using a sputtering target that comprises a doped or alloyed piezoelectric material. In examples, the layer of piezoelectric material is deposited onto the substrate using high power impulse magnetron sputtering (HIPIMS). Further enhancement may be obtained using substrate biasing (e.g. DC and/or RF) during deposition of the layer of piezoelectric material.

Abstract: Described herein is a method for manufacturing, or for use in manufacturing a flexible ultrasonic transducer array and the resultant ultrasonic transducer array. The method includes providing a layer of piezoelectric material onto a foil substrate and using additive techniques to apply at least one electrode to a surface of the piezoelectric material such that the electrodes are arranged in an electrode array. The method also includes using the additive techniques to applying a plurality of electrical conduction tracks and a plurality of electrical connectors to the surface of the piezoelectric material or to a layer of dielectric material provided on the surface of the piezoelectric material, such that respective electrical conduction tracks electrically connect a respective electrode to a respective electrical connector. The additive techniques comprise at least one of: masking, deposition, photo patterning, printing or patterned coating.

Abstract: A fastener for coupling a magnetic target to a nut plate base is provided. The fastener includes a body defining an opening. Furthermore, when the fastener is coupled to the nut plate base, the opening is aligned with an opening defined by the nut plate base and configured to accommodate a floating nut.

Abstract: A turbine with multiple gas inlets is designed by a process of, for a given engine, obtaining time series data characterizing the power bias of the engine, obtaining an isentropic power associated with each data point of the time series, and using the isentropic powers to obtain a design point. The turbine is then designed based on the design point, such as by optimising one or more design parameters of the turbine based on the design point.

Abstract: A downhole tool having a mandrel, a first slip, a second slip, a lower sleeve, and a tethered ball assembly. The mandrel includes a proximate end; a distal end; a bore having a ball seat associated therewith; and an outer surface. The first slip is disposed around the mandrel. The second slip is disposed around the mandrel. The lower sleeve is proximate to the first slip, and engaged with the outer surface at the distal end. The tethered ball assembly includes a ball; a drag; and at least one tether coupled between the ball and the drag.

Abstract: A turbine comprises a housing defining a turbine chamber with a turbine wheel supported for rotation about an axis. The housing further defines first and second inlet volutes which each spiral radially inwards and extend from a respective inlet to adjoin the turbine chamber and a volute tongue for each inlet volute. The tongue of the first volute radially separating a downstream portion of the first volute adjacent the chamber from an upstream portion of the first volute adjacent said inlet of the first volute, and the tongue of the second volute radially separating a downstream portion of the second volute adjacent the chamber from an upstream portion of the second volute adjacent said inlet of the second volute. The tongues having a turbine scroll tongue overlap which is substantially zero or positive; and the first volute tongue is angularly spaced about the axis from the second volute tongue.

Abstract: A turbine comprises a turbine wheel for rotation within a turbine housing, the turbine housing including at least one volute arranged to deliver a fluid to the turbine wheel via the turbine nozzle. A method for determining a width of a turbine nozzle for the turbine, comprises selecting from a relationship between a turbine stage efficiency and an effective nozzle area, at least one target effective nozzle area. As used here, the effective nozzle area is dependent on both the width of the turbine nozzle and a whirl angle induced by the at least one volute. The method further comprises determining, in dependence on the whirl angle, the width of the turbine nozzle as a width that will achieve the at least one target effective nozzle area.

Abstract: The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Abstract: A downhole tool suitable for use in a wellbore, the tool comprising a hybrid sleeve in the form of a mandrel sleeve; and a sleeve insert disposed within the mandrel sleeve. The tool further includes a first slip disposed about the mandrel sleeve; and a second slip disposed about the mandrel sleeve and proximate to a conical surface. There is a lower sleeve proximate to the second slip. At least a portion of the sleeve insert is radially laterally proximate to a sealing element disposed around the mandrel.

Abstract: A downhole tool having a mandrel, a first slip, a second slip, a lower sleeve, and a tethered ball assembly. The mandrel includes a proximate end; a distal end; a bore having a ball seat associated therewith; and an outer surface. The first slip is disposed around the mandrel. The second slip is disposed around the mandrel. The lower sleeve is proximate to the first slip, and engaged with the outer surface at the distal end. The tethered ball assembly includes a ball; a drag; and at least one tether coupled between the ball and the drag.

Abstract: A downhole tool having a mandrel, and a bottom slip disposed around the mandrel. The bottom slip includes a circular body having a one-piece configuration characterized by a plurality of slip segments by at least partial material connectivity therearound. The bottom slip is made of a filament wound composite material, which means the bottom slip has a plurality of layers joined by respective interface layers. An outer slip surface of at least one of the plurality of slip segments is defined in cross-section by a plane P that intersects a longitudinal axis of the downhole tool at an angle a1 in a range of 10 degrees to 20 degrees when the bottom slip is in an unset position.

Abstract: Non-visible objects which differ in their physical properties from their surroundings by association with a variable strength magnetic field may be detected by a suitable array of sensors which can be moved relative to the object in question. By analyzing the signals from the plurality of the sensors in the array, the position of the object can be deduced relative to the array and the array moved to enable a machining guide thereon to be aligned with the non-visible object. The system is of particular value in locating apertures in wing spars when attempting to fix the skin of the wing on to them where it is important to be able to locate the correct point at which to drill a hole through the skin to coincide with the hole in the spar. By defining a magnetic field in the vicinity of the hole to identify the hole magnetically and using an array of magnetic field sensors in a base with an aperture, it is possible to shift the array so that the aperture is precisely aligned with the non-visible hole.