Patents by Inventor David A. Igel

David A. Igel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9101772
    Abstract: A method of stimulation therapy and an apparatus for providing the therapy which addresses cardiac dysfunction including heart failure. The therapy employs atrial pacing pulses delivered to a heart after the atrial refractory period and timed so that they will not cause a ventricular contraction. These atrial pacing are timed to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
    Type: Grant
    Filed: December 9, 2009
    Date of Patent: August 11, 2015
    Assignee: Medtronic, Inc.
    Inventors: Karen J. Kleckner, Kathleen A. Prieve, Jeffrey M. Gillberg, Ren Zhou, Kenneth M. Anderson, D. Curtis Deno, Glenn C. Zillmer, Ruth N. Klepfer, Vincent E. Splett, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel, John E. Burnes
  • Patent number: 9042982
    Abstract: Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: May 26, 2015
    Assignee: Medtronic, Inc.
    Inventors: John E. Burnes, Yong K. Cho, David Igel, Luc R. Mongeon, John C. Rueter, Harry Stone, Jodi Zilinski
  • Publication number: 20120303084
    Abstract: The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 29, 2012
    Applicant: Medtronic, Inc.
    Inventors: Karen J. Kleckner, Kathleen A. Prieve, Jeffrey M. Gillberg, Ren Zhou, Kenneth M. Anderson, D. Curtis Deno, Glenn C. Zillmer, Ruth N. Klepfer, Vincent E. Splett, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel, John E. Burnes
  • Publication number: 20120150253
    Abstract: Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
    Type: Application
    Filed: February 20, 2012
    Publication date: June 14, 2012
    Applicant: Medtronic, Inc.
    Inventors: John E. Burnes, Yong K. Cho, David Igel, Luc R. Mongeon, John C. Rueter, Harry Stone, Jodi Zilinski
  • Patent number: 8135463
    Abstract: Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: March 13, 2012
    Assignee: Medtronic, Inc.
    Inventors: John E. Burnes, Yong K. Cho, David Igel, Luc R. Mongeon, John C. Rueter, Harry Stone, Jodi Zilinski
  • Publication number: 20100210954
    Abstract: A system and method for cardiovascular analysis includes an implantable medical device capable of generating hemodynamic pressure waveform data based upon sensed pressure. Hemodynamic waveform data is analyzed to identify artifactual data represented in the hemodynamic waveform.
    Type: Application
    Filed: April 28, 2010
    Publication date: August 19, 2010
    Applicant: Medtronic, Inc.
    Inventors: Tommy D. BENNETT, Mark CHOI, David A. IGEL, Michael R.S. HILL, Teresa A. WHITMAN
  • Publication number: 20100152804
    Abstract: The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 17, 2010
    Applicant: Medtronic, Inc.
    Inventors: Karen J. Kleckner, Kathleen A. Prieve, Jeffrey M. Gillberg, Ren Zhou, Kenneth M. Anderson, D. Curtis Deno, Glenn C. Zillmer, Ruth N. Klepfer, Vincent E. Splett, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel, John E. Burnes
  • Patent number: 7708693
    Abstract: A system and method for cardiovascular analysis includes an implantable medical device capable of generating hemodynamic pressure waveform data based upon sensed pressure. Hemodynamic waveform data is analyzed to identify artifactual data represented in the hemodynamic waveform.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 4, 2010
    Assignee: Medtronic, Inc.
    Inventors: Tommy D. Bennett, Mark Choi, David A. Igel, Michael R. S. Hill, Teresa A. Whitman
  • Patent number: 7711423
    Abstract: Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: May 4, 2010
    Assignee: Medtronic, Inc.
    Inventors: John E. Burnes, David A. Igel, John C. Rueter, Yong K. Cho, Luc R. Mongeon, Harold E. Stone, Jodi Zilinski
  • Patent number: 7367951
    Abstract: A cardiovascular analysis system and method includes an implantable medical device with a sensor positioned to sense a hemodynamic pressure over time. The implantable medical device generates hemodynamic pressure waveform data based upon the hemodynamic pressure sensed. A processor analyzes the hemodynamic waveform data to provide an indication of cardiovascular health based upon prominent peaks in the hemodynamic waveform data.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 6, 2008
    Assignee: Medtronic, Inc.
    Inventors: Tommy D. Bennett, Mark Choi, David A. Igel, Michael R. S. Hill, Teresa A. Whitman, Douglas A. Hettrick
  • Publication number: 20070299477
    Abstract: The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
    Type: Application
    Filed: June 19, 2007
    Publication date: December 27, 2007
    Inventors: Karen Kleckner, Kathleen Prieve, Jeffrey Gillberg, Ren Zhou, Kenneth Anderson, D. Deno, Glenn Zillmer, Ruth Klepfer, Vincent Splett, David Euler, Lawrence Mulligan, Edwin Duffin, David Igel, John Burnes
  • Patent number: 7292888
    Abstract: A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse train of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments, the medical device delivers pulses according to a schedule stored in a memory, or as a function of a monitored physiological parameter of a patient, such as an intracardiac pressure. In some embodiments, the medical device suspends or withholds delivery of neurally-excitable based on detection of cardiac ischemia.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: November 6, 2007
    Assignee: Medtronic, Inc.
    Inventors: D. Curtis Deno, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel
  • Publication number: 20070213778
    Abstract: Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
    Type: Application
    Filed: May 21, 2007
    Publication date: September 13, 2007
    Inventors: John Burnes, Yong Cho, David Igel, Luc Mongeon, John Rueter, Harry Stone, Jody Zilinski
  • Patent number: 7228174
    Abstract: Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: June 5, 2007
    Assignee: Medtronics, Inc.
    Inventors: John E. Burnes, Yong K. Cho, David Igel, Luc R. Mongeon, John C. Rueter, Harry Stone, Jodi Zilinski
  • Publication number: 20060271117
    Abstract: Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.
    Type: Application
    Filed: May 24, 2005
    Publication date: November 30, 2006
    Inventors: John Burnes, David Igel, John Rueter, Yong Cho, Luc Mongeon, Harold Stone, Jodi Zilinski
  • Publication number: 20060167360
    Abstract: A system and method for cardiovascular analysis includes an implantable medical device capable of generating hemodynamic pressure waveform data based upon sensed pressure. Hemodynamic waveform data is analyzed to identify artifactual data represented in the hemodynamic waveform.
    Type: Application
    Filed: January 27, 2005
    Publication date: July 27, 2006
    Inventors: Tommy Bennett, Mark Choi, David Igel, Michael Hill, Teresa Whitman
  • Publication number: 20060167359
    Abstract: A cardiovascular analysis system and method includes an implantable medical device with a sensor positioned to sense a hemodynamic pressure over time. The implantable medical device generates hemodynamic pressure waveform data based upon the hemodynamic pressure sensed. A processor analyzes the hemodynamic waveform data to provide an indication of cardiovascular health based upon prominent peaks in the hemodynamic waveform data.
    Type: Application
    Filed: January 27, 2005
    Publication date: July 27, 2006
    Inventors: Tommy Bennett, Mark Choi, David Igel, Michael Hill, Teresa Whitman, Douglas Hettrick
  • Publication number: 20050038479
    Abstract: A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse train of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments, the medical device delivers pulses according to a schedule stored in a memory, or as a function of a monitored physiological parameter of a patient, such as an intracardiac pressure. In some embodiments, the medical device suspends or withholds delivery of neurally-excitable based on detection of cardiac ischemia.
    Type: Application
    Filed: August 11, 2003
    Publication date: February 17, 2005
    Inventors: D. Deno, David Euler, Lawrence Mulligan, Edwin Duffin, David Igel
  • Patent number: 6738667
    Abstract: An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP=systolic P−diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (&tgr;); (2) mechanical restitution (MR), i.e., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of heart cycles; and (4) end systolic elastance (EES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: May 18, 2004
    Assignee: Medtronic, Inc.
    Inventors: D. Curtis Deno, Lawrence J. Mulligan, Tom D. Bennett, David A. Igel, Michael R. S. Hill, Richard J. Shaw
  • Publication number: 20030204212
    Abstract: Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
    Type: Application
    Filed: April 29, 2002
    Publication date: October 30, 2003
    Inventors: John E. Burnes, Yong K. Cho, David Igel, Luc R. Mongeon, John C. Rueter, Harry Stone, Jodi Zilinski