Abstract: The present disclosure describes systems and methods for using patient-specific genomic information to optimize or de-risk therapy for the patient. A user may identify a medication for consideration for prescription to a patient, and a genetic variant of the patient affecting a first protein. An analyzer may identify a second medication targeting the first protein, and may retrieve adverse event data from an adverse event database for patients co-medicated with both the first medication and second medication. The analyzer may determine, based on rates of adverse events, the likelihood of an adverse event occurring through co-medication of the first medication and second medication. Based on the likelihood, and based on a correspondence or non-correspondence between a protein activation characteristic of the first medication and the effect of the genetic variant of the patient, the analyzer may indicate or contra-indicate the first medication for the patient.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: The present disclosure relates to aerosol delivery devices. The aerosol delivery devices include mechanisms configured to deliver an aerosol precursor composition from a reservoir to an atomizer including a heating element to produce a vapor. An actuator may displace a rod to dispense the aerosol precursor composition to the atomizer. Thereby, the rod may move a piston in a pump housing to dispense the aerosol precursor composition. The atomizer may define a chamber in which the heating element is positioned and at which the aerosol precursor composition is vaporized.

Abstract: A touch-sensitive rotary control device with an illumination function includes a rotary encoder having a conductive outer casing and a rotatable shaft extending from it, the shaft operating as a light guide for a light source located in the rotary encoder, a conductive sleeve mechanically coupled to and surrounding the side of shaft, and electrically coupled to the conductive outer casing of the rotary encoder, so that touch-sensitivity is provided and light is allowed to exit the shaft and such that the device can be provided as a kit of parts or form part of a mixing console.

Abstract: Among other things, videos and commercials are downloaded to a mobile device for storage on the mobile device and later playout on the mobile device. The downloading includes downloading of metadata associated with the commercials and based on which the mobile device can select commercials for insertion into videos being played back to the user of the mobile device. The commercials to be downloaded are selected based on one or a combination of any two or more of the location of the user, the type of mobile device, and personally-identifiable information about a user of the mobile device.

Abstract: An internal combustion engine can include a piston moving in a cylinder and a junk head disposed opposite the piston head in the cylinder. The junk head can optionally be moveable between a higher compression ratio position closer to a top dead center of the piston and a lower compression ratio position further from the top dead center position of the piston. At least one intake port can deliver a fluid comprising inlet air to a combustion chamber within the cylinder. Combustion gases can be directed out of the combustion volume through at least one exhaust port. One or both of the intake port and the exhaust port can be opened and closed by operation of a sleeve valve that at least partially encircles the piston. Related articles, systems, and methods are described.

Abstract: A suture implant device includes: a splice; a fixed loop having a first fixed end at a first end of the splice and a second fixed end at the first end of the splice; an adjustable loop having a fixed end at the second end of the splice and an adjustable end at the second end of the splice, the adjustable end passes through the at least a portion of the splice so that a tensioning strand extending from the adjustable loop protrudes from the splice; a needle on the fixed loop; and a member on the adjustable loop. A method of cinching a first tissue to a second tissue includes: attaching the suture implant to a first tissue; attaching the suture implant to a second tissue; and cinching the first tissue to the second tissue without the suture implant sliding against or through the first tissue.

Abstract: An imaging lens system allows for the use of interchangeable lens elements. The interchangeable element may be any type of device that affects the image produced by the imaging lens and is preferably inserted into the lens at a position at or near the aperture stop. The lens housing preferably includes an insertion area which allows for the placement of the interchangeable element.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

Abstract: A method of playing a side game concurrently playable with a game of roulette includes accepting side bet wagers from players in a first side game during a wager phase for the game of roulette. The side bet wagers are independent of wagers placed on the roulette game. Two or more side game symbols are selected from a first symbol set which are playable in the game of roulette. Each of the side game symbols are assigned a payout value, such that at least one of the assigned payout values is a fixed payout value utilized for each play of the side game and another of the assigned payout values is a variable payout value. A determination is made if any of the selected side game symbols match a winning roulette symbol. Side game prizes are awarded to winning side bet players according to the corresponding assigned payout value.

Abstract: Among other things, videos and commercials are downloaded to a mobile device for storage on the mobile device and later playout on the mobile device. The downloading includes downloading of metadata associated with the commercials and based on which the mobile device can select commercials for insertion into videos being played back to the user of the mobile device. The commercials to be downloaded are selected based on one or a combination of any two or more of the location of the user, the type of mobile device, and personally-identifiable information about a user of the mobile device.

Abstract: A vehicle wheel alignment system has a plurality of cameras, each camera for viewing a respective target disposed at a respective wheel of the vehicle and capturing image data of the target as the wheel and target are continuously rotated a number of degrees of rotation without a pause. The image data is used to calculate a minimum number of poses of the target of at least one pose for every five degrees of rotation as the wheel and target are continuously rotated the number of degrees of rotation without a pause. At least one of the cameras comprises a data processor for performing the steps of preprocessing the image data, and calculating an alignment parameter for the vehicle based on the preprocessed image data.

Abstract: A portable vehicle alignment system has a vertical central column with a carriage movable along its length, and a pair of camera arms pivotably attached to the carriage, each with a camera pod. The camera pods each have a camera for capturing image data of a respective vehicle-mounted target. One pod also has a calibration target disposed in a known relationship to its camera, and the other pod has a calibration camera disposed in a known relationship to its camera for capturing images of the calibration target. The camera arms pivot between an extended position where the cameras are disposed to capture image data of the vehicle targets and the calibration camera is disposed to capture images of the calibration target, and a folded position where the aligner has a width smaller than the width between the camera pods.

Abstract: An inverted combustion engine is described herein that can reduce or eliminate the amount of oil that leaks into a combustion volume of a combustion chamber. In some implementations, at least one piston of the combustion engine includes a crown that faces the combustion volume and a cavity on an opposing side of the crown that is configured to collect and contain oil that has entered the combustion chamber.

Abstract: The invention relates to a method for modifying a template polynucleotide for characterization, especially for nanopore sequencing. The method produces a modified polynucleotide which is complementary to the template polynucleotide at some positions and which contains universal or abasic nucleotides at the other, and in some instances predicable, positions. The resulting modified polynucleotide can then be characterized.

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.