Abstract: A system to perform reversible transvenous electroporation includes an electroporation generator and a controller operably coupled to the electroporation generator. The controller is configured to instruct the electroporation generator to generate a voltage signal to perform electroporation, where the voltage signal has a predetermined range of voltages and a predetermined range of pulse widths to ensure that the electroporation is reversible, and where the voltage signal is biphasic or monophasic. The controller also delivers the voltage signal to a catheter to perform the electroporation, where the catheter includes one or more electrodes through which the voltage signal is delivered.

Abstract: Computer-implemented systems and methods are provided for automatically conforming guidance of work vehicles to detected conditions in a work area. Upon determining a deviation of a work vehicle's current movement path from a first planned movement path with respect to the work area, at least a portion of the work area may be identified as a region of interest, along with coverage characteristics associated with the region of interest, based at least in part on the determined deviation. A second planned movement path is generated for the work vehicle and/or another work vehicle subsequently traversing the work area relative to the region of interest, wherein the generated second planned movement path accounts for the coverage characteristics associated with the region of interest. The second planned movement path may be generated to avoid the region, prevent turns within the region, optimize work vehicle operation within the work area generally, etc.

Abstract: A mobile device includes a processor and memory, coupled to the processor, which memory contains instructions that when executed cause the processor to provide an autonomy management application. The autonomy management application includes an autonomy approval function. The autonomy approval function provides a user interface configured to display at least one aspect of an autonomy job to a user and receive user acceptance of the autonomy job. The autonomy approval function is configured to instruct the user to move within a pre-determined distance from an autonomous work machine that will execute the autonomy job and provide a machine-verified indication of user proximity within the pre-determined distance.

Abstract: A mobile device includes a processor and memory, coupled to the processor, which memory contains instructions that when executed cause the processor to provide an autonomy management application. The autonomy management application includes an autonomy approval function. The autonomy approval function provides a user interface configured to display at least one aspect of an autonomy job to a user and receive user acceptance of the autonomy job. The autonomy approval function is configured to instruct the user to move within a pre-determined distance from an autonomous work machine that will execute the autonomy job and provide a machine-verified indication of user proximity within the pre-determined distance.

Abstract: Computer-implemented systems and methods are provided for automatically conforming guidance of work vehicles to detected conditions in a work area. Upon determining a deviation of a work vehicle's current movement path from a first planned movement path with respect to the work area, at least a portion of the work area may be identified as a region of interest, along with coverage characteristics associated with the region of interest, based at least in part on the determined deviation. A second planned movement path is generated for the work vehicle and/or another work vehicle subsequently traversing the work area relative to the region of interest, wherein the generated second planned movement path accounts for the coverage characteristics associated with the region of interest. The second planned movement path may be generated to avoid the region, prevent turns within the region, optimize work vehicle operation within the work area generally, etc.

Abstract: A control system for an autonomous work machine includes a robotic controller, a position detection system coupled to the robotic controller, and a sensor coupled to the robotic controller and configured to provide a sensor signal. A controlled system is coupled to the robotic controller to receive control signals from the robotic controller. The robotic controller is configured to generate an event relative to an object in an environment around the autonomous work machine or a machine health/job quality issue, document the event, and store the documented event. The robotic controller is further configured to selectively generate a communication containing at least some information relative to the documented event to a supervisor and to receive user input from the supervisor and take responsive action based on the user input.

Abstract: System and methods for generating a work plan for a headland of an agricultural field (e.g., the portion of the agricultural field that is used by an agricultural machine to perform edge turns while working a main work partition of the field). A field boundary polygon indicative of a workable area of the agricultural field is segmented into multiple segments including a headland polygon and a work partition polygon. A seed track is generated based on a shape of a portion of the boundary of the headland polygon that is shared in common with the boundary of the field boundary polygon. The work plan is generated by replicating the seed track at a defined spacing throughout the headland polygon. In some implementations, the agricultural machine is operated autonomously or semi-autonomously to work the headland area based on the defined work plan.

Abstract: A system for treating atrial fibrillation includes a memory configured to store a baseline measurement of an atrial fibrillation characteristic of a patient and a post administration measurement of the atrial fibrillation characteristic of the patient. The post administration measurement is obtained subsequent to administration of a reactive oxygens species (ROS) scavenger to the patient. The system also includes a processor operatively coupled to the memory and configured to determine a change between the baseline measurement and the post administration measurement of the atrial fibrillation characteristic. The processor is further configured to identify, based on the determined change, one or more hot spots of atrial fibrillation, where the one or more hot spots comprise target areas for treatment of the atrial fibrillation.

Abstract: System and methods for generating a work plan for a headland of an agricultural field (e.g., the portion of the agricultural field that is used by an agricultural machine to perform edge turns while working a main work partition of the field). A field boundary polygon indicative of a workable area of the agricultural field is segmented into multiple segments including a headland polygon and a work partition polygon. A seed track is generated based on a shape of a portion of the boundary of the headland polygon that is shared in common with the boundary of the field boundary polygon. The work plan is generated by replicating the seed track at a defined spacing throughout the headland polygon. In some implementations, the agricultural machine is operated autonomously or semi-autonomously to work the headland area based on the defined work plan.

Abstract: A system for performing integrated mapping and electroporation includes a basket catheter that includes a plurality of splines and a plurality of electrodes mounted to each spline in the plurality of splines. The system also includes a controller device connected to the basket catheter. The controller device includes a processor configured to activate at least a subset of electrodes to perform electroporation, where activation of at least the subset of electrodes generates current paths between electrodes on a given spline and between electrodes on adjacent splines.

Abstract: The disclosure is the only product of its kind that is compact in size, requires low water, and has the ability to control urine splash back. This unprecedented product is uniquely designed with durable materials to ensure long term sustainability and can be easily installed in any location. The disclosure includes a handheld receptacle having a top orifice for receiving a urine and a bottom orifice for discharging the urine. The disclosure also includes a hose connected to the handheld receptacle in a rotatable connection, the hose comprising a trap run and a discharge end, wherein a user rotates the trap run and discharge end to a target holding the handheld receptacle.

Abstract: A digital fence of a work area is generated and loaded into a machine control system that controls an off-road machine. The machine control system detects whether the off-road machine is within a threshold distance of the digital fence and automatically controls operating parameters of the off-road machine when the off-road machine is within a threshold distance of the digital fence.

Abstract: The herein described Adaptive Ergonomic Positioning device (“AEPD”) relates generally to the field of surgery and other medical or healthcare procedures. The AEPD can be adapted for use with most standard surgical tables and surgical chairs where the patient must be positioned prone during a particular procedure. The AEPD may also be used for certain procedures where the patient may be positioned supine. The AEPD support assemblies are highly adjustable and deliver improved ergonomics for both patients and providers. Patients of different morphology can be comfortably positioned in prone with their head and neck in a neutral position, and shoulders in a forward flexed, slightly internally rotated position. The AEPD can be adjusted to accommodate patients with neck and shoulder mobility restrictions, without any effect on provider accessibility to the surgical or treatment site.

Abstract: A mobile device includes a processor and memory, coupled to the processor, which memory contains instructions that when executed cause the processor to provide an autonomy management application. The autonomy management application includes an autonomy approval function. The autonomy approval function provides a user interface configured to display at least one aspect of an autonomy job to a user and receive user acceptance of the autonomy job. The autonomy approval function is configured to instruct the user to move within a pre-determined distance from an autonomous work machine that will execute the autonomy job and provide a machine-verified indication of user proximity within the pre-determined distance.

Abstract: A control system for an autonomous work machine includes a robotic controller, a position detection system coupled to the robotic controller, and a sensor coupled to the robotic controller and configured to provide a sensor signal. A controlled system is coupled to the robotic controller to receive control signals from the robotic controller. The robotic controller is configured to generate an event relative to an object in an environment around the autonomous work machine or a machine health/job quality issue, document the event, and store the documented event. The robotic controller is further configured to selectively generate a communication containing at least some information relative to the documented event to a supervisor and to receive user input from the supervisor and take responsive action based on the user input.

Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

Abstract: The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)—active and toll-like receptor (TLR8)—active imidazoquinolines and oxoadenines.

Abstract: This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

Abstract: The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)-active and toll-like receptor (TLR8)-active imidazoquinolines and oxoadenines.