Abstract: A system for compensating for phase noise, with particular application in lidar, includes a compensation interferometer that receives a signal from a source, and splits it into a first and second path, with a path length difference ?? between them. Typically the path length is significantly less than that of the return distance to a target. The output of the compensation interferometer, which consists of phase noise generated in time ?? is vectorially summed during a time similar to a signal flight time to a target, and the result used to reduce phase noise present on measurements of a target. It further includes means for selecting ?? such that competing noise elements are reduced or optimised.

Abstract: A system for compensating for phase noise, with particular application in lidar, includes a compensation interferometer that receives a signal from a source, and splits it into a first and second path, with a path length difference ?? between them. Typically the path length is significantly less than that of the return distance to a target. The output of the compensation interferometer, which consists of phase noise generated in time ?? is vectorially summed during a time similar to a signal flight time to a target, and the result used to reduce phase noise present on measurements of a target. It further includes means for selecting ?? such that competing noise elements are reduced or optimised.

Abstract: Described are methods, systems and apparatus for hypothesizing a biological relationship in a biological system. A database of biological assertions is provided consisting of biological elements, relationships among the biological elements, and relationship descriptors characterizing the properties of the elements and relationships. A biological element may be selected from the database and a logical simulation may be performed within the biological database, from the selected biological element, through relationship descriptors, along a path defined by potentially causative biological elements to discern a biological element hypothetically responsible for the change in the selected biological element.

Abstract: Described are methods, systems and apparatus for hypothesizing a biological relationship in a biological system. A database of biological assertions is provided consisting of biological elements, relationships among the biological elements, and relationship descriptors characterizing the properties of the elements and relationships. A biological element may be selected from the database and a logical simulation may be performed within the biological database, from the selected biological element, through relationship descriptors, along a path defined by potentially causative biological elements to discern a biological element hypothetically responsible for the change in the selected biological element.

Abstract: Disclosed are methods, systems and apparatus for constructing assemblies of biological knowledge constituting a biological knowledge base, and for subsetting and transforming life sciences-related data and information into biological models to facilitate computation and electronic reasoning on biological information. A subset of data is extracted from a global knowledge base or repository to reconstruct a more specialized sub-knowledge base or assembly designed specifically for the purpose at hand. Assemblies generated by the invention permit selection and rational organization of seemingly diverse data into a model of any selected biological system, as defined by any desired biological criteria. These assemblies can be mined easily and can be logically reasoned with great productivity and efficiency.

Abstract: Described are methods, systems and apparatus for hypothesizing a biological relationship in a biological system. A database of biological assertions is provided consisting of biological elements, relationships among the biological elements, and relationship descriptors characterizing the properties of the elements and relationships. A biological element may be selected from the database and a logical simulation may be performed within the biological database, from the selected biological element, through relationship descriptors, along a path defined by potentially causative biological elements to discern a biological element hypothetically responsible for the change in the selected biological element.

Abstract: Disclosed are methods, systems and apparatus for constructing assemblies of biological knowledge constituting a biological knowledge base, and for subsetting and transforming life sciences-related data and information into biological models to facilitate computation and electronic reasoning on biological information. A subset of data is extracted from a global knowledge base or repository to reconstruct a more specialized sub-knowledge base or assembly designed specifically for the purpose at hand. Assemblies generated by the invention permit selection and rational organization of seemingly diverse data into a model of any selected biological system, as defined by any desired biological criteria. These assemblies can be mined easily and can be logically reasoned with great productivity and efficiency.

Abstract: An epistemic engine system and methods are provided, which accept biological data from experiments or other sources, and automatically produce a model, such as a genomic and protein interaction network, which attempts to explain the operation of a biological system. The system and methods identify interrelationships among components of a biological system, consistent with the biological data and other life science knowledge. In preferred embodiments, evolutionary algorithms are used, in combination with information from a life science knowledge base and experimental data, to generate models that may identify these interrelationships. The output of an epistemic engine permits scientists to better understand biological systems, to propose hypotheses, to build more complete models, and to propose new experiments to test the validity of their hypotheses.