Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(triflu-oromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl] [2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of car-diopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic tromboembolic pulmonary hyperten-sion (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pu

Abstract: An ultrasound blood vessel imaging system can include a 3D ultrasound probe operable to capture 3D volume data of tissue containing one or more blood vessels. A processor can be in communication with the 3D ultrasound probe and configured to receive the data and convert the data to a volume of ultrasound images. The processor can process the ultrasound images using an image segmentation method to identify a blood vessel lumen independent of surrounding tissue and generate a segmented vessel. The processor can also generate a constructed view of the blood vessel by assembling the segmented vessel and display the constructed view on an electronic display.

Abstract: A continuously variable transmission has an input shaft, an output shaft, an intermediate shaft connected to the output shaft and to the input shaft via one or more tooth engagements, a variator transmission arranged on the intermediate shaft, a hydrostatic transmission, a housing, and a bearing plate. The housing at least partially encloses the input shaft, the output shaft, and the intermediate shaft. The hydrostatic transmission is arranged geometrically parallel to the variator transmission, and the power flow can be split therebetween. The output shaft is offset horizontally and vertically with respect to the input shaft. The housing is in one piece and open on one side. The components are held in the housing by the bearing plate in the mounted state. One or more of the housing and the bearing plate have flat surfaces on outer sides, which are configured to fasten module components on the continuously variable transmission.

Abstract: A hemostatic surface application device having a region of hemostatic foam for contact with a patient's skin where a wound exists or is created, the device includes: a release layer, the release layer in contact with a hemostatic flexible foam section, and a structural foam layer having a front side and a back side surrounding the hemostatic flexible foam layer, forming a generally central hemostatic surface exposed through the front side of the surrounding structural foam layer, and a support layer adhered to the backside of the structural foam layer.

Abstract: A hemostatic surface application device having a region of hemostatic foam for contact with a patient's skin where a wound exists or is created, the device includes: a release layer, the release layer in contact with a hemostatic flexible foam section, and a structural foam layer having a front side and a back side surrounding the hemostatic flexible foam layer, forming a generally central hemostatic surface exposed through the front side of the surrounding structural foam layer, and a support layer adhered to the backside of the structural foam layer.

Abstract: Described herein is a system and method for determining the presence and/or amount of a target in a sample. In some embodiments, a microfluidic device, such as a strip having a microfluidic network thereon, is inserted into an instrument to perform an assay therein. The strip may be configured to receive the sample from a porous member via capillary action, with minimal or no compression of the porous member. The instrument may include a gas bladder actuation assembly, actuated by an eccentric cam, to compress and decompress a gas bladder on the microfluidic device, thereby enabling fluid movement thereon. The instrument may further comprise a magnet disposed in a fixed location, so as to capture any complexes formed between the target and magnetic particles disposed within the microfluidic device. The magnet may be aligned with an optical detection assembly configured to detect the target captured with the magnetic particles.

Abstract: A hemostatic surface application device having a region of hemostatic foam for contact with a patient's skin where a wound exists or is created, the device includes: a release layer, the release layer in contact with a hemostatic flexible foam section, and a structural foam layer having a front side and a back side surrounding the hemostatic flexible foam layer, forming a generally central hemostatic surface exposed through the front side of the surrounding structural foam layer, and a support layer adhered to the backside of the structural foam layer.

Abstract: A multiport splitter with a circuit that is less costly, smaller, impedance matched on all ports, provides 9.54 dB isolation between neighboring ports, and is balanced as compared to the current typical implementations. The present disclosure may further provide a single multiport splitter that may be increased to any suitable number of output ports without the need for cascading multiple splitters and/or couplers together in a single device.

Abstract: A hemostatic surface application device having a region of hemostatic foam for contact with a patient's skin where a wound exists or is created, the device includes: a release layer, the release layer in contact with a hemostatic flexible foam section, and a structural foam layer having a front side and a back side surrounding the hemostatic flexible foam layer, forming a generally central hemostatic surface exposed through the front side of the surrounding structural foam layer, and a support layer adhered to the backside of the structural foam layer.

Abstract: A method of manufacturing a multi material device for heat transfer, and a multi material device is disclosed comprising: depositing, by an additive manufacturing technique, a first material onto a scaffold; depositing, by an additive manufacturing technique, a second material onto at least part of the first material, wherein, one of the first or second material is a heat transfer material having first thermal conductivity, a first chemical resistance and a first erosion resistance and the other is a rugged material of a second thermal conductivity, a second chemical resistance and a second erosion resistance, such that the second thermal conductivity is lower than the first thermal conductivity and at least one of the second chemical resistance or second erosion resistance is higher that the respective first chemical resistance or first erosion resistance.

Abstract: A beam-like crosshead for a valve train of an internal combustion engine is proposed for the transmission of a cam lift to two gas exchange valves. The crosshead has two side walls which are connected by a transverse wall, and, on an upper side of the transverse wall at its longitudinal center, a contact surface for a cam follower, and, on an underside of the transverse wall at each of its longitudinal ends, a valve contact surface. The crosshead is a reversed bowl-like hollow body which is produced from steel sheet using stamping/bending technology. From the transverse wall the side walls and, transversely at each longitudinal end, end walls hang in a finger-like manner. Cut edges between the side and end walls, starting from the transverse wall, form cut-outs.

Abstract: A multiport splitter with a circuit that is less costly, smaller, impedance matched on all ports, provides 9.54 dB isolation between neighboring ports, and is balanced as compared to the current typical implementations. The present disclosure may further provide a single multiport splitter that may be increased to any suitable number of output ports without the need for cascading multiple splitters and/or couplers together in a single device.

Abstract: The present invention relates to methods for detecting an analyte present in a fluid sample using a microfluidic device comprising a detection zone characterized by an optically transmissible portion and reagent(s) associated with a porous matrix, wherein the analyte is detected with an optical detector. The present invention also provides a microfluidic channel and a microfluidic cartridge for use in such a method.

Abstract: A system and associated method determines the characteristics of an electric network including distance to a fault through the use of a power divider and a measuring device that measures a quantity from which voltage magnitude can be determined. The measuring device may be a power detector. The power detector may include a power meter to measure voltage and/or a power sensor to measure amplitude. Then, the results from the power detector are used in conjunction with a Hilbert transform to estimate the phase associated with at least two voltage magnitudes when a combined signal is a minimum phase signal.

Abstract: A novel method for synthesizing AEI zeolites is provided which results in high overall relative yields on silica and the structure directing agent.

Abstract: A spark-ignited (SI) internal combustion (IC) engine designed to operate on high octane fuels, such as gasoline, is reconfigured to operate on low octane fuels including logistically preferred distillate fuels, such as diesel or JP-8. Design modifications involve coupling a fuel reformer module to the internal combustion engine. Auxiliary components include a system control module, a heat exchange module, a bypass valve to facilitate start-up, and/or a throttle body to control a reformate-oxidizer mixture fed to the engine. Small portable generators having 0.3-3.0 kWe power output are disclosed based upon the modified SI-IC engine design.

Abstract: A system and method for analyzing a device under test is provided. The system includes a signal source for generating an incident signal. The incident signal is routed to one or more inputs of the device under test. The system further includes signal separation and routing circuitry for measuring a portion of the incident signal to provide a reference signal and for separating the incident signal and a reflected signal at the one or more inputs of the device under test. The signal separation circuitry for separating the incident signal and the reflected signal at the input of the device under test is accomplished by a resistive device. The system may further include sampling device operationally coupled to the resistive device. The system and method may further include a signal switching mechanism for sequentially routing time slices of two or more signals to be coherently compared.

Abstract: A system and associated method determines the characteristics of an electric network including distance to a fault through the use of a power divider and a measuring device that measures a quantity from which voltage magnitude can be determined. The measuring device may be a power detector. The power detector may include a power meter to measure voltage and/or a power sensor to measure amplitude. Then, the results from the power detector are used in conjunction with a Hilbert transform to estimate the phase associated with at least two voltage magnitudes when a combined signal is a minimum phase signal.