Patents by Inventor David A. Lasky
David A. Lasky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8487078Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.Type: GrantFiled: October 4, 2011Date of Patent: July 16, 2013Assignee: Life Technologies CorporationInventors: Tony Klink, Jane Beebe, David Lasky, Karen Kleman-Leyer, Richard Somberg
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Publication number: 20120083427Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.Type: ApplicationFiled: October 4, 2011Publication date: April 5, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Tony KLINK, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
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Patent number: 8067536Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.Type: GrantFiled: March 22, 2010Date of Patent: November 29, 2011Assignee: Life Technologies CorporationInventors: Tony Klink, Jane Beebe, David Lasky, Karen Kleman-Leyer, Richard Somberg
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Publication number: 20100240080Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.Type: ApplicationFiled: March 22, 2010Publication date: September 23, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
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Patent number: 7727752Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.Type: GrantFiled: July 14, 2006Date of Patent: June 1, 2010Assignee: Life Technologies CorporationInventors: Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
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Patent number: 7619059Abstract: Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase or phosphatase, alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition when it is associated noncovalently with a probe composition that includes a second binding member and a second detectable moiety. Panel assays for determining substrates or modulators of enzymatic activities are also described.Type: GrantFiled: September 9, 2004Date of Patent: November 17, 2009Assignee: Life Technologies CorporationInventors: Kevin R. Kupcho, Kurt Vogel, Elizabeth A. Werner, Jane A. Beebe, Tony A. Klink, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
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Patent number: 7582461Abstract: Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase or phosphatase alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase or phosphatase activity are also described.Type: GrantFiled: July 29, 2004Date of Patent: September 1, 2009Assignee: Life Technologies CorporationInventors: Elizabeth A. Werner, Tony A. Klink, Jane A. Beebe, David A. Lasky, Karen M. Kleman-Leyer, Richard Somberg
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Publication number: 20070059787Abstract: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described.Type: ApplicationFiled: July 14, 2006Publication date: March 15, 2007Applicant: Invitrogen CorporationInventors: Tony Klink, Jane Beebe, David Lasky, Karen Kleman-Leyer, Richard Somberg
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Publication number: 20050170442Abstract: Compositions, methods, and kits for detecting and monitoring post-translational modification activities, including kinase or phosphatase activities, are described. The compositions typically include a peptide, a first detectable moiety, a first binding member, and a protease cleavage site. Modification of a composition by a post-translational modification enzyme, such as a kinase or phosphatase, alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition when it is associated noncovalently with a probe composition that includes a second binding member and a second detectable moiety. Panel assays for determining substrates or modulators of enzymatic activities are also described.Type: ApplicationFiled: September 9, 2004Publication date: August 4, 2005Inventors: Kevin Kupcho, Kurt Vogel, Elizabeth Werner, Jane Beebe, Tony Klink, David Lasky, Karen Kleman-Leyer, Richard Somberg
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Publication number: 20050054573Abstract: Compositions, methods, and kits for detecting and monitoring kinase or phosphatase activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase or phosphatase alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase or phosphatase activity are also described.Type: ApplicationFiled: July 29, 2004Publication date: March 10, 2005Inventors: Elizabeth Werner, Tony Klink, Jane Beebe, David Lasky, Karen Kleman-Leyer, Richard Somberg