Patents by Inventor David A. Leib

David A. Leib has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for preventing or ameliorating neonatal HSV infection
    Patent number: 12378305
    Abstract: The present disclosure relates to compositions and methods for treating or preventing neonatal herpes simplex virus (HSV) infection and/or the neurological and/or non-neurological sequelae thereof.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: August 5, 2025
    Assignees: Trustees of Dartmouth College, Duke University
    Inventors: Margaret E. Ackerman, Iara M. Backes, David A. Leib, Chaya D. Patel, Michael Anthony Moody
  • COMPOSITIONS AND METHODS FOR PREVENTING OR AMELIORATING NEONATAL HSV INFECTION
    Publication number: 20250101084
    Abstract: The present disclosure relates to anti-HSV (herpes simplex virus) antibodies comprising an Fc region having at least one modification or mutation that confers enhanced effector function and/or improved binding to viral Fc receptor (vFcR) and uses of such antibodies for preventing or ameliorating the effects of a neonatal HSV infection.
    Type: Application
    Filed: January 6, 2023
    Publication date: March 27, 2025
    Inventors: Margaret E. ACKERMAN, Iara M. BACKES, David A. LEIB
  • COMPOSITIONS AND METHODS FOR PREVENTING OR AMELIORATING NEONATAL HSV INFECTION
    Publication number: 20210340223
    Abstract: The present disclosure relates to compositions and methods for treating or preventing neonatal herpes simplex virus (HSV) infection and/or the neurological and/or non-neurological sequelae thereof.
    Type: Application
    Filed: October 10, 2019
    Publication date: November 4, 2021
    Inventors: Margaret E. Ackerman, Iara M. Backes, David A. Leib, Chaya D. Patel, Anthony M. Moody
  • Herpes simplex virus mutant UL41NHB
    Patent number: 5698431
    Abstract: A herpes simplex virus (HSV) mutant, UL41NHB, is disclosed which is deficient in the virion host shutoff (vhs) function. This mutant is shown to be profoundly attenuated in its ability to replicate at the periphery and in the nervous system, and in its ability to reactivate from latency.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: December 16, 1997
    Assignee: Washington University
    Inventor: David A. Leib