Patents by Inventor David A. Lewin

David A. Lewin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • WNT-regulated cytokine-like polypeptide and nucleic acids encoding same
    Patent number: 7566536
    Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: July 28, 2009
    Assignees: CuraGen Corporation, Genentech, Inc.
    Inventors: David P. Andrew, David A. Lewin, Diane Pennica, Luca Rastelli, Bruce Tallion
  • Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
    Patent number: 7005499
    Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: February 28, 2006
    Assignees: Genentech, Inc., Curagen Corporation
    Inventors: David A. Lewin, Diane Pennica, Luca Rastelli, Bruce Taillon
  • Acidic mammalian proteins and polynucleotides encoding the same
    Patent number: 6872704
    Abstract: Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity and other metabolic disorders.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: March 29, 2005
    Assignees: Genentech, Inc., Curagen Corporation
    Inventors: Karen M. Kelly, David A. Lewin, Timothy A. Stewart
  • BFIT compositions and methods of use
    Publication number: 20030220238
    Abstract: Isolated polynucleotides encoding brown fat inducible thioesterase (BFIT) polypeptides and the polypeptides are provided. Methods of using these polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: January 22, 2002
    Publication date: November 27, 2003
    Inventors: Sean H. Adams, Clarissa J. Chui, Audrey D. Goddard, J. Christopher Grimaldi, David A. Lewin
  • GPCR-like retinoic acid-induced gene 1 protein and nucleic acid
    Publication number: 20030207288
    Abstract: A novel G-protein coupled receptor-like retinoic acid induced molecule was identified as being differentially expressed (GPCR-like RAIG1) in an animal model of fasting and feeding. Compositions and methods pertaining to treatment and diagnosis of various metabolic disorders, such as cachexia and obesity.
    Type: Application
    Filed: August 20, 2002
    Publication date: November 6, 2003
    Inventors: David A. Lewin, Timothy A. Stewart
  • Mammalian genes modulated during fasting and feeding
    Publication number: 20030208057
    Abstract: Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity.
    Type: Application
    Filed: May 7, 2002
    Publication date: November 6, 2003
    Inventors: David A. Lewin, Timothy A. Stewart
  • Novel acidic mammalian proteins and polynucleotides encoding the same
    Publication number: 20030203375
    Abstract: Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity and other metabolic disorders.
    Type: Application
    Filed: October 9, 2002
    Publication date: October 30, 2003
    Applicant: Genentech, Inc.
    Inventors: Karen M. Kelly, David A. Lewin, Timothy A. Stewart
  • Protein-protein complexes and methods of using same
    Publication number: 20030157554
    Abstract: The invention provides complexes of at least two polypeptides, and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids encoding chimeric polypeptides and vectors and cells containing the same. Also provided are methods of identifying agents that disrupt polypeptide complexes, methods of identifying complex or polypeptide in a sample, and for removing the same, methods of determining altered expression of a polypeptide in a subject, and methods of treating/preventing disorders involving altered levels of complex or polypeptide.
    Type: Application
    Filed: October 30, 2001
    Publication date: August 21, 2003
    Inventors: Loic Giot, Andrew Eisen, David A. Lewin