Abstract: Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.

Abstract: Disclosed are a liquid pearlescent composition (e.g., a liquid pearlescent concentration) that is free of a preservative, a personal product including the composition, and a method of use the same.

Abstract: Aspects of this disclosure relate to detecting and recording information associated with electrical overstress (EOS) events, such as electrostatic discharge (ESD) events. For example, in one embodiment, an apparatus includes an electrical overstress protection device, a detection circuit configured to detect an occurrence of the EOS event, and a memory configured to store information indicative of the EOS event.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: The present disclosure provides for a flow therapy apparatus that can implement one or more closed loop control systems to control the flow of gases of a flow therapy apparatus. The flow therapy apparatus can monitor blood oxygen saturation (SpO2) of a patient and control the fraction of oxygen delivered to the patient (FdO2). The flow therapy apparatus can automatically adjust the FdO2 in order to achieve a targeted SpO2 value for the patient.

Abstract: Vehicle seat systems, especially seat systems for aircraft passengers are provided. In preferred forms, the aircraft seat systems according to the embodiments disclosed herein will include a seat base assembly, a seat tracking/swivel assembly fixed to the seat base assembly and a seat bucket fixed to the seat tracking/swivel assembly.

Abstract: Food preparation apparatus and associated appliance modules and methods. Appliances modules can be selectively docked at docks of an appliance interface of a base. An appliance module includes a food container support surface movable between cooking and holding positions. An appliance module includes a receptacle having a holding well that can be selectively configured in a generally horizontal position or an inclined position.

Abstract: Electroacoustic drivers that can be utilized in loudspeaker systems that utilize drivers having a magnetic negative spring (MNS) (such as reluctance assist drivers (RAD) and permanent magnet crown (PMC) drivers). The electroacoustic drivers can be used at all audio frequencies, including subwoofer frequencies. The magnetic negative springs of the electroacoustic drivers can cancel, or partially cancel, the large pressure forces on a sound panel (of an audio speaker) so that substantial subwoofer notes can be efficiently and cost effectively produced in small/portable speakers. The electroacoustic drivers can include a stabilizing/centering mechanism to overcome the destabilizing forces of a MNS that are too large for a voice coil alone to produce.

Abstract: A system for determining vehicle location information includes a receiver supported on a first vehicle for receiving a communication from a second vehicle and a signal from each of a plurality of satellites. A detector is configured to detect a positional relationship between the first vehicle and the second vehicle. A processor is configured to determine a location of the first vehicle from received satellite signals, a location of the second vehicle based on the communication received from the second vehicle, a corrected location of the first vehicle based on the location of the second vehicle and the positional relationship between the vehicles, and a corrective mapping of a plurality of sections of a field of view of the receiver. Each section has ad correction factor for correcting a subsequently determined location of the first vehicle based on satellite signals received from satellites appearing in the respective sections.

Abstract: A pump panel training device is provided and includes a plurality of simulated gages operable to imitate gages upon a fire truck pump panel, a plurality of simulated controls operable to imitate controls upon the fire truck pump panel, and a simulated water hose operable to imitate one of water temperature changes, water temperature pressure, and water hose vibration for the fire truck pump panel.

Abstract: An illustrative example embodiment of a method of processing information regarding movement of a first vehicle based on information regarding movement of at least one second vehicle includes: receiving a communication from the second vehicle that includes information regarding movement of the second vehicle, determining that the movement of the second vehicle corresponds to movement of the first vehicle, identifying at least one feature of the movement of the second vehicle that indicates an environmental condition that affects the movement of the second vehicle, identifying a sensor indication of movement of the first vehicle that corresponds to the feature of the movement of the second vehicle, and excluding the identified sensor indication from information used to determine movement of the first vehicle.

Abstract: The invention relates to substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5?-monophosphate-activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof and at least one pharmaceutically acceptable excipient, and methods of treating a condition comprising administering AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

Abstract: Methods and systems are provided for determining a plurality of traction limits corresponding to each of a plurality of wheels of a vehicle and determining a grounded torque request. Based on the plurality of traction limits, the grounded torque request is distributed to each of the plurality of wheels. If a grounded torque request to a first wheel of the plurality of wheels exceeds a traction limit for the first wheel, the torque to the first wheel may be reduced, and an increased torque is applied to a second wheel of the plurality of wheels.

Abstract: A row unit for an agricultural implement has a mounting device with a rail portion for sliding engagement with a seed delivery device to facilitate quick and easy installation and removal of the seed delivery device without the use of tools. A seed meter is mounted to the underside of a cover such that as the cover is opened the seed meter moves with the cover away from the seed delivery device to provide convenient access to both the seed meter and the seed delivery device. A cam and pawl arrangement selectively retains the cover in the open position.

Abstract: Provided herein are compositions and methods for driving high expression of a transgene. Compositions and methods for driving high expression of a transgene comprising one or more human-derived regulatory elements, which, when operably linked to a transgene, can result in high expression of the transgene in one or more cell types or tissues.

Abstract: Apparatus and methods for testing network cabling includes processing circuitry that receives an indication of a user-selected network test of a plurality of network tests. The respective network tests have respective sets of test requirements with different levels of rigor. The test circuitry conducts a wire map test to identify which network tests can be conducted. Thereafter, a common set of test results is produced based on measurement of a common set of parameters pertinent to the network tests that can be conducted. The processing circuitry evaluates the common set of test results with respect to the respective sets of test requirements to determine one or more passing network tests. A plurality of test reports corresponding to the plurality of network tests is graphically displayed along a curve having a common center, wherein each test report indicates whether the corresponding network test is a passing network test.

Abstract: An electronic portion of a CRPA antenna of an anti-jamming device for a GNSS receiver, including M elementary signal inputs, for each input, a bandpass filter bank which is configured to break down each elementary signal received by this input at a frequency Fe, into P sub-bands to obtain P sub-sampled signals at a frequency Fe/P, a calculational component which is configured to apply in parallel anti-jamming processing at the frequency Fe/P to the sub-sampled signals, to obtain a cleaned sub-sampled signal, and a summation component which is configured to receive all the cleaned sub-sampled signals and to form, from these sub-sampled signals a resulting corresponding cleaned signal at the frequency Fe.

Abstract: An imaging needle apparatus, associated system, and method of use are described. The apparatus includes various interchangeable modules, including a trocar assembly, a blunt cannula assembly, and an arthroscope assembly, such as a nano-arthroscope. For example, using the imaging needle apparatus, a doctor can treat a patient by inserting the trocar assembly into the patient's body, inserting the blunt cannula assembly into the body via the trocar assembly, removing the trocar assembly, and inserting the arthroscope assembly into the blunt cannula assembly. Further, the imaging needle apparatus, in some embodiments, includes a light engine that provides a light source for a camera cannula of the apparatus, such as a camera cannula that is part of the arthroscope assembly.

Abstract: An entity modeling system integrated with a low-code application development platform may have a web/mobile-based user interface that can run in a browser environment on user devices ranging from desktop computers to smart phones. Users such as a subject matter expert may access an entity model designer tool of the system to model an entity. Responsive to user interaction with an entity composition function, the system may access a data store over a network and generate a view including a collection of entity building block(s) retrieved from the data store. Responsive to the user selecting a first entity building block from the collection to add to the entity, the system may automatically extend the entity to include settings of the first entity building block. The settings may include at least one of a property, permission, action, behavior, or resource to the entity.