Abstract: Provided herein are APP RNAi agents and compositions comprising an APP RNAi agent. Also provided herein are methods of using the APP RNAi agents or compositions comprising an APP RNAi agent in reducing APP expression and/or treating APP associated neurological diseases.

Abstract: A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. A cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. In example embodiments, the male plug is tapered and can comprise one or more projections for sealingly engaging with the lumen of the connector. According to some example embodiments, the cap can be tethered to the connector.

Abstract: Systems, methods, and non-transitory computer-readable media for continuously monitoring residential air quality and providing a trend based analysis regarding various air pollutants are presented herein. The system comprises an air quality monitor located in a residential house, wherein the air quality monitor is configured to measure the level of an air pollutant. The system also includes a server that is communicatively coupled to the air quality monitor, wherein the server is configured to generate a unique environmental fingerprint associated with the residential house.

Abstract: Methodologies, systems, and computer-readable media provided for a system for generating personalized electronic documents and verifying user identity are discussed. The system receives user identification data and check information from a user application. The check information is validated by the issuer of the check. The system transmits a notification to the user application that includes a machine readable code. The user application presents the machine readable code and the user identification data to a check-in module and automatic processing of the check is initiated.

Abstract: The present disclosure relates to engines with multiple cylinder banks. Systems and methods are disclosed that relate to engine operations that balance the output from the cylinder banks to improve engine health and performance.

Abstract: Low-cost and robust platforms are key for the development of next-generation 3D micro- and nanodevices. To fabricate such platforms, nanocrystalline diamond (NCD) is a highly appealing material due to its biocompatibility, robustness, and mechanical, electrical, electrochemical, and optical properties, while glass substrates with through vias are ideal interposers for 3D integration due to the excellent properties of glass. A low-cost process—free of photolithography and transfer printing—for fabricating arrays of TGVs that are sealed with suspended portions of an ultra-thin NCD film on one side is presented. These highly transparent structures may serve as a platform for the development of microwells for single-cell culture and analysis, 3D integrated devices such as microelectrodes, and quantum technologies. It is also possible to replace the NCD with silicon nitride or silicon carbide, allowing for the development of complex heterogeneous structures on a small scale.

Abstract: A driving simulation system includes a simulated driver cockpit which includes simulated controls, a display control input, and a video display providing a simulated driving environment to the driver. The system further includes a computerized simulation control module including programming to operate a driving simulation. The driving simulation includes driving rules. The module further including programming to monitor performance of the driver during the driving simulation and compare the performance of the driver to the driving rules. The module further includes programming to generate an untextualized feedback regarding performance of the driver relative to the driving rules, monitor an input by the driver to the display control input, and selectively display the untextualized feedback to the driver based upon the input by the driver to the display control input. The selective display is operable to enable private viewing of the untextualized feedback by the driver.

Abstract: Soil additives that include at least a diatomaceous earth ingredient, a calcium sulfate ingredient, and a biochar ingredient. Soil additives that include at least a diatomaceous earth ingredient, a calcium sulfate ingredient, and a limestone ingredient. Related methods of making and using such soil additives for growing crops.

Abstract: Described herein are systems and methods for the management and control of electrolyte within confined electrochemical cells or groups (e.g. stacks) of connected electrochemical cells, for example, in an electrolyzer. Various embodiments of systems and methods provide for the elimination of parasitic conductive paths between cells, and/or precise passive control of fluid pressures within cells. In some embodiments, a fixed volume of electrolyte is substantially retained within each cell while efficiently collecting and removing produced gases or other products from the cell.

Abstract: A valve for a breathing apparatus system includes a housing extending axially from a first end to a second end, with the first end fluidly coupled to the mask and the second end configured to fluidly couple with a source of breathable air. An air flow path extends through the housing between the first end and the second end.

Abstract: A camera system includes a monochrome camera, having a global shutter, to capture a first image of a scene, and a color camera, disposed separately from the monochrome camera and having a global shutter, to capture a second image of the scene. The second image is aligned to the first image and color information of the second image is provided to the first image to obtain a third image representing the scene.

Abstract: A method may include generating current and voltage (I-V) data of a photovoltaic (PV) panel at a plurality of predetermined time intervals during operation of the PV panel. The method may also include generating environmental data of a site of the PV panel at the plurality of predetermined time intervals. In addition, the method may include generating I-V characteristic data based on the I-V data and the environmental data. The I-V characteristic data may be representative of actual operating performance of the PV panel over a predetermined period of time corresponding to a duration of the predetermined time intervals.

Abstract: A terminal includes a terminal body extending between a mating end and a terminating end. The mating end has a mating interface. The terminating end has an insulation displacement contact. The insulation displacement contact includes a first contact element having a first blade and a second contact element having a second blade. The first blade faces the second blade across a cable slot configured to receive a cable. The terminal includes a contact support extending along the insulation displacement contact. The contact support holds the first contact element relative to the second contact element.

Abstract: Disclosed is an apparatus configured to operate in at least one therapy mode and at least one non-therapy mode. After a predetermined time operating in the at least one non-therapy mode, the apparatus is configured to: transmit the data to a device, and/or receive a software package from a or the device, and/or receive therapy parameters from a or the device, and/or update parameters of the apparatus.

Abstract: Apparatuses including spark gap structures for electrical overstress (EOS) monitoring or protection, and associated methods, are disclosed. In an aspect, a vertical spark gap device includes a substrate having a horizontal main surface and a plurality of pairs of conductive layers over the horizontal main surface. Different ones of the pairs are separated by different vertical distances such that each pair serves as an arcing electrode pair and different ones of the arcing electrode pairs are configured to arc discharge at different voltages.

Abstract: A method and system are disclosed for providing electrical power from a utility electric grid to a fracturing operation, and an electrically powered fracturing system. A mobile substation includes at least two transformer units that are operatively coupled to the utility electric grid in a parallel orientation, wherein the transformer units are capable of receiving power from the utility electric grid and stepping down the power for delivery to a switchgear. An electric motor is operatively coupled to a hydraulic fracturing pump and operatively controlled by a variable frequency drive. At least one open air relay cable is operatively coupled between the switchgear and the electric motor and capable of delivering power to the electric motor.

Abstract: A downhole tool to be positioned in a wellbore in a subsurface formation. The downhole tool comprises a first rod configured with a first cavity to obtain samples of formation fluid. The downhole tool comprises a translating member configured to shift the first rod from an open position to a closed position to obtain, via the first cavity, a first fluid sample of the formation fluid from a first location in the wellbore.

Abstract: An exercise platform with components that can be attached and/or stacked in a safe and secure manner. The exercise platform includes an inclined board and a set of blocks that are attached to each other and/or stacked on top of each other. A bottom surface of the inclined board may include one or more sets of apertures, and the blocks include one or more corresponding sets of protrusions and apertures. The inclined board is attached to the top side of a block, of the set of blocks, with the protrusions of the block meshed with apertures of the inclined board. Further blocks may be stacked in similar manner to permit a user to adjust a height of the exercise platform.

Abstract: An example system for digital wallet management including one or more databases and a computing system is described. The databases are configured to store data corresponding to purchase history of a user, the purchase history including payment account information for a first transaction captured through a reader at a point-of-sale system at the time of the first transaction and an identifier associated with the first transaction. The computing system receives a machine-readable element having the identifier associated with the first transaction encoded therein, searches the databases to determine the payment account information associated with the identifier, generates a prompt requesting confirmation of adding the payment account information for the first transaction to a digital wallet, receives positive confirmation to the generated prompt, and populates the digital wallet with the payment account information.

Abstract: Systems, methods, and computer-readable media are presented herein for providing lower level physical-layer gateway functionalities and upper-level application functionalities; a system designed with flexible configurations in order to support a wide range of connected applications. The system includes a processor that executes machine instructions to perform operations. The operations comprise: receiving sensor data from a sensor device located in a building; converting the sensor data from a raw state to a physical measurement; and activating an abatement device situated in the building as a function of the physical measurement.