Abstract: Methods and polypeptides for conferring site-specific or local immune privilege.

Abstract: Disclosed is an antibody library comprising a plurality of antibodies with non-naturally occurring combinations of complementary determining regions from memory and naïve B-cells naturally occurring in humans, and wherein the antibody library comprises a high number of functional and non-redundant antibodies. Further disclosed are methods of preparing antibody libraries with a high level of functional diversity.

Abstract: Methods and compounds for conferring site-specific or local immune privilege, such as targeting to a cell expressing MAdCAM.

Abstract: Processes for optimizing the geometry of a blade for use in a propeller are disclosed. In one exemplary process, an optimization routine that generates new blade geometries based on structural parameters and calculates performance parameters of each blade geometry, including aerodynamic performance parameters, farfield acoustic parameters, and/or electrical power requirements to operate a propeller having the blade geometry, is performed. The optimization routine receives design parameters and weightings from a user and can use one or more surrogate algorithms to map a design space of the weighted values of the design parameters to find their local minima. The optimization routine then determines an optimized blade geometry using a gradient-based algorithm to generate new blade geometries to explore the minima until the weighted values of the design parameters converge at an optimized blade geometry representing the global minima of the design space.

Abstract: Disclosed herein are methods for selecting polypeptides that specifically bind to a target protein. In some cases, the methods involve panning a library of polypeptides for target polypeptides that bind to a target protein on the surface of a cell. Additionally, the disclosure provides cell lines expressing target proteins for use with the disclosed methods.

Abstract: A bicycle for transporting loads and individuals, wherein the rear wheel is arranged with a first spacing from the front wheel and wherein the bicycle is constructed to be able to be adjusted in terms of length by the front wheel and/or the rear wheel being able to be moved from a first position into a second position so that the rear wheel and the front wheel in the second position are arranged with a second spacing from each other, wherein the second spacing is greater than the first spacing, and wherein the bicycle both with the first spacing and with the second spacing from the front wheel and rear wheel is ready to ride or can be ridden.

Abstract: Methods and polypeptides for conferring site-specific or local immune privilege.

Abstract: Binding agents that bind to a transferrin receptor are provided. This transferrin receptor binding can allow binding agents to cross the blood-brain barrier and into other tissues, such as the eye and synovium. These binding agents can be utilized for diagnostic or therapeutic purposes. The binding agents can also be modified to improve their activity, to bind to more than one target antigen, or a combination thereof.

Abstract: Processes for optimizing the geometry of a blade for use in a propeller are disclosed. In one exemplary process, an optimization routine that generates new blade geometries based on structural parameters and calculates performance parameters of each blade geometry, including aerodynamic performance parameters, farfield acoustic parameters, and/or electrical power requirements to operate a propeller having the blade geometry, is performed. The optimization routine receives design parameters and weightings from a user and can use one or more surrogate algorithms to map a design space of the weighted values of the design parameters to find their local minima. The optimization routine then determines an optimized blade geometry using a gradient-based algorithm to generate new blade geometries to explore the minima until the weighted values of the design parameters converge at an optimized blade geometry representing the global minima of the design space.

Abstract: Disclosed is an antibody library comprising a plurality of antibodies with non-naturally occurring combinations of complementary determining regions from memory and naïve B-cells naturally occurring in humans, and wherein the antibody library comprises a high number of functional and non-redundant antibodies. Further disclosed are methods of preparing antibody libraries with a high level of functional diversity.

Abstract: Methods and compounds for conferring site-specific or local immune privilege, such as targeting to a cell expressing MAdCAM.

Abstract: The present invention relates to a lightweight, high resolution portable ultrasound system using components and methods to improve connectivity and ease of use. A preferred embodiment includes an integrated system in which the beamformer control circuitry can be inserted into the host computer as a peripheral or within the processor housing.

Abstract: A multipurpose cleaning trowel is provided. The cleaning trowel includes a base having a first side, a second side, a flexible section, a blade section, and a mounting section positioned between the flexible section and the blade section. The cleaning trowel further includes a handling device removably secured to the first side of the base at the mounting section and a cleaning pad receiving region. A cleaning pad is removably secured to the base. The handling device is interchangeable between a fixed handle and a swivel base.

Abstract: A mesh back mop head includes a cleaning surface and a backing member. The cleaning surface is secured to the backing member along a plurality lines to define channels in the cleaning surface. The backing member is formed from an open mesh material that substantially allows the free flow of liquid therethrough. The backing member includes at least one receiver operably mounted to the backing member for receiving a mop head frame. A cleaning system and a method of cleaning using the mesh back mop head are disclosed.

Abstract: A multipurpose cleaning trowel is provided. The cleaning trowel includes a base having a first side, a second side, a flexible section, a blade section, and a mounting section positioned between the flexible section and the blade section. The cleaning trowel further includes a handling device removably secured to the first side of the base at the mounting section and a cleaning pad receiving region. A cleaning pad is removably secured to the base. The handling device is interchangeable between a fixed handle and a swivel base.

Abstract: A mesh back mop head includes a cleaning surface and a backing member. The cleaning surface is secured to the backing member along a plurality lines to define channels in the cleaning surface. The backing member is formed from an open mesh material that substantially allows the free flow of liquid therethrough. The backing member includes at least one receiver operably mounted to the backing member for receiving a mop head frame. A cleaning system and a method of cleaning using the mesh back mop head are disclosed.

Abstract: The present invention relates to a lightweight, high resolution portable ultrasound system using components and methods to improve connectivity and ease of use. A preferred embodiment includes an integrated system in which the beamformer control circuitry can be inserted into the host computer as a peripheral or within the processor housing.

Abstract: A method of mopping a floor is disclosed.

Abstract: A mop assembly including a mop head and handle, and a supply of liquid connected to a valve assembly on the handle. The valve assembly includes a replaceable length of resiliently flexible tubing having a portion extending transversely through the handle and members on opposite sides of the length of tubing that are relatively movable between a closed position pinching together opposite sides of the tubing to stop the flow of liquid through it, and a spaced open position affording flow of liquid through the tube. A storage cart includes a main portion and a tray portion having a receptacle for receiving the mop head mounted on the main portion for relative movement between a vertical closed position at which the main portion covers an open side of the receptacle; and a horizontal open position at which the mop head can be inserted into or removed from the receptacle.

Abstract: A Shop Vacuum Cleaner commonly utilized for the Industrial and non industrial environments alike. Our shop vacuum cleaner, hereafter known as the “Retrac-A-Vac”. Said Retrac-A-Vac is vacuum cleaning product which incorporates extremely unique features. Said Retrac-A-Vac's uniqueness rests in its' ability and “on demand”, to in real time extend, deploy and retract, draw back its' vacuum hose. Said Retrac-A-Vac's real time hose manipulation feature though unique in itself, is supported by other internal mechanical advantages within unit. The additional features inasmuch when grouped together, collectively and in a mutual sense support the main feature's true functionality. As a result and united together they are indeed unique notwithstanding in themselves. The Retrac-A-Vac embodiment encompasses a cylindrical outer housing covering.