Abstract: Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

Abstract: According to aspects of the present disclosure, systems, methods and computer program products can be provided for dynamic workload orchestration based on data complexity. Methods, computer program products and/or systems are provided for dynamic workload orchestration that perform the following operations: (i) receiving a workload for orchestration; (ii) computing complexity scores for respective portions of the workload, where the complexity scores are computed based at least on parameters describing data associated with the portions of the workload; and (iii) using an orchestration engine to assign the portions of the workload to corresponding compute resources, based on their respective complexity scores.

Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

Abstract: An apparatus, according to an exemplary aspect of the present disclosure includes, among other things, a clip body having a vehicle side and a panel side. A first clip is on the vehicle side and a second clip is on the panel side. A seal is on the vehicle side. A method according to an exemplary aspect of the present disclosure includes, among other things, attaching the first clip to a vehicle body, and subsequently attaching a panel to the second clip such that the seal is positioned between the clip body and the vehicle body.

Abstract: Methods of generating structural models of highly deviated or horizontal wells may be generated from the measurement of true stratigraphic thickness in three dimensions (TST3D). In one aspect, methods may include generating a structural model from one or more deviation surveys of a horizontal well, one or more single channel log measurements, and a three-dimensional reference surface.

Abstract: An apparatus, according to an exemplary aspect of the present disclosure includes, among other things, a clip body having a vehicle side and a panel side. A first clip is on the vehicle side and a second clip is on the panel side. A seal is on the vehicle side. A method according to an exemplary aspect of the present disclosure includes, among other things, attaching the first clip to a vehicle body, and subsequently attaching a panel to the second clip such that the seal is positioned between the clip body and the vehicle body.

Abstract: For controlling a level of luminance produced by a color light-emitting diode (LED) array, a method includes: for a predetermined flux bit-slice period, activating a color enable signal to select a primary color LED and to select a predetermined light flux magnitude set-point; selectively charging an energy storage device and discharging the energy storage device through the selected primary color LED to generate a light flux output during the flux bit-slice period; adjusting a rate of selectively charging the energy storage device to maintain a magnitude of the light flux output at the predetermined light flux magnitude set-point during the flux bit-slice period; and adjusting the predetermined light flux magnitude set-point over the life of the selected LED as the selected LED ages as a function of an anode-to-cathode voltage drop across the selected LED for a given magnitude of current flowing through the selected LED.

Abstract: For controlling a level of luminance produced by a color light-emitting diode (LED) array, a method includes: for a predetermined flux bit-slice period, activating a color enable signal to select a primary color LED and to select a predetermined light flux magnitude set-point; selectively charging an energy storage device and discharging the energy storage device through the selected primary color LED to generate a light flux output during the flux bit-slice period; adjusting a rate of selectively charging the energy storage device to maintain a magnitude of the light flux output at the predetermined light flux magnitude set-point during the flux bit-slice period; and adjusting the predetermined light flux magnitude set-point over the life of the selected LED as the selected LED ages as a function of an anode-to-cathode voltage drop across the selected LED for a given magnitude of current flowing through the selected LED.

Abstract: Light flux levels sensed from a color LED array control both current availability to the array and disable/re-enable a current bypass switch to shunt stored-energy current to or away from a selected LED. In continuous mode, a single flux pulse is created for the duration of a pre-established period. Feedback from the flux sensor pulses current to an energy storage device to maintain the light flux at a predetermined set-point. A particular dimming level is achieved by establishing both the pulse period and the flux magnitude. In discontinuous mode, one or more short flux pulses are created. Both the turn-on and the turn-off time of each flux pulse is controlled by alternately removing and then re-establishing a current shunt from the energy storage device to ground. Flux pulse magnitude is controlled by recognizing when the flux pulse has reached a predetermined set-point and re-establishing the current shunt to abruptly turn off current to the selected LED.

Abstract: A device for measuring tissue hardness of a subject comprising: a housing, the housing having a proximal end and a distal end; a contact probe configured to contact tissue arranged on the distal end of the housing; a sensor assembly configure to measure tissue hardness disposed within the housing; a microprocessor configured to receive input from the sensor assembly; a force transduction assembly disposed within the housing; a microprocessor receiving input from the displacement sensor and the force sensor; and a display, receiving input from the microprocessor, configured to display information to a user on the proximal end of the housing.

Abstract: Methods of generating structural models of highly deviated or horizontal wells may be generated from the measurement of true stratigraphic thickness in three dimensions (TST3D). In one aspect, methods may include generating a structural model from one or more deviation surveys of a horizontal well, one or more single channel log measurements, and a three-dimensional reference surface.

Abstract: A method of sorting items that are received for further shipment includes determining a first quantity of the items to be placed into a first tote and a second quantity of the items to be placed into a second tote. The first tote conveys the items to a first location for immediate shipping to a first set of customers who have ordered only the item. The second tote conveys the items to a second location for matching with different items before being shipped to a second set of customers who have ordered combinations of the item and one or more of the different items. In response to receipt of the items, a first quantity of the items is placed into the first tote in accordance with the determined first quantity, and a second quantity of the items is placed into the second tote in accordance with the determined second quantity.

Abstract: Linking multiple identities from a single service includes for a user of a single service having multiple identities within the single service, authenticating a primary identity having a first buddy list associated with an account, authenticating a secondary identity having a second buddy list associated with the account, and creating an association between the primary identity and the secondary identity, where the primary identity and the secondary identity simultaneously share a common graphical user interface such that the primary identity interacts with the first buddy list and the secondary identity interacts with the second buddy list using the common graphical user interface.

Abstract: Light flux levels sensed from a color LED array control both current availability to the array and disable/re-enable a current bypass switch to shunt stored-energy current to or away from a selected LED. In continuous mode, a single flux pulse is created for the duration of a pre-established period. Feedback from the flux sensor pulses current to an energy storage device to maintain the light flux at a predetermined set-point. A particular dimming level is achieved by establishing both the pulse period and the flux magnitude. In discontinuous mode, one or more short flux pulses are created. Both the turn-on and the turn-off time of each flux pulse is controlled by alternately removing and then re-establishing a current shunt from the energy storage device to ground. Flux pulse magnitude is controlled by recognizing when the flux pulse has reached a predetermined set-point and re-establishing the current shunt to abruptly turn off current to the selected LED.

Abstract: Video signals in a video stream are encoded by inserting reference signals in the video stream such that the encoded video stream carry both reference signals and video signals being coded. In the decoding stage, reference images generated from the reference signals are detected and used for identifying the encoded video signals based upon the profiles of the detected reference images. An imaging architecture capable of using the coding scheme comprises a shutter that can be implemented as a dual-processor configuration.

Abstract: A computer-implemented method is provided that automatically characterizes and verifies stationarity of a training image for use in multipoint geostatistical analysis. The stationarity is preferably characterized by statistical measures of orientation stationarity, scale stationarity, and category distribution stationarity.

Abstract: The present invention relates to the use of inhibitors or blockers of Ih (hyperpolarization-activated cationic current) channels in the treatment of cognitive disorders.

Abstract: An extermination device for exterminating pests includes a holder, trigger mechanism and a resilient ring mounted on the holder. When a pest actuates the trigger mechanism, the ring is released from the holder onto the pest, thereby killing the pest in a humane manner. A cover may be provided to protect the trigger mechanism from dirt and animals larger than target pest size. A loading device having a tapering body adapted to allow a resilient ring to be expanded from the narrow end to the wide end of the tapering body, wherein the wide end includes a formation adapted to engage with a holder of an extermination device.