Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least section wise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: A display panel includes a first set of pixels that each include a respective red sub-pixel and a respective green sub-pixel and a second set of pixels that each include a respective blue sub-pixel and a respective green sub-pixel, where the first set of pixels and the second set of pixels are arranged on the display panel such that at least one side of each of the pixels in the first set of pixels is adjacent to at least one of the pixels in the second set of pixels, at least one side of each of the pixels in the first set of pixels is not adjacent to any pixel, and the green sub-pixels are arranged on the display panel such that the green sub-pixels are evenly distributed in the display panel.

Abstract: A seatbelt of a vehicle includes a buckle tilt mounting device for a tongue plate coupled with a seatbelt webbing restraining an occupant seated in a vehicle seat. The buckle tilt mounting device includes a buckle assembly having a buckle and a buckle cable, and further includes a pre-tensioner system having a housing, a driving member, and a pre-tensioner cable. When the pre-tensioner system is actuated at a time of a vehicle collision or at a time a vehicle collision is anticipated, the driving member retracts the pre-tensioner cable inside the housing such that the buckle assembly is rotatably moved and configured to reduce submarining load on the occupant.

Abstract: Apparatuses, systems and methods for wearable devices such as eyewear are described. According to one embodiment, the wearable device includes a body, electronics, and a connector. The body is configured to hold one or more optical elements, the body being disposable between a collapsed condition and a wearable condition in which the device is wearable by a user to hold the one or more optical elements within user view. The electronics are carried by the body. The connector is configured to enable establishment of an electrical and/or electronic connection with the electronics via the connector, the connector being housed by the body such that the connector is substantially obscured from view when the body is in the wearable condition, and such that the connector is exposed for connective access when the body is in the collapsed condition.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: An implement attachment holder for a hand mixer includes a body defining opposed first and second surfaces and first and second mounting projections coupled with the body and extending away from the first surface of the body at respective first and second locations spaced apart at a first distance along a first direction. The attachment holder further includes a device retention projection extending away from the second surface of the body and partially along the first surface to at least partially overlie the first and second locations from which the first and second mounting projections extend. The device retention projection further defines a plurality of attachment channels extending in a second direction normal to the first direction at spaced-apart locations along the device retention projection.

Abstract: An augmented reality (AR) platform supports concurrent operation of multiple AR applications developed by third-party software developers. The AR platform may include an application programming interface (API) that third-party software developers can use to integrate features of the AR platform into the overall user experience of their AR applications. The AR platform includes a feature set having a variety of AR-specific features that interact with and are accessible to the AR applications or AR layers that define a collection of AR content.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: A surgical device includes a handpiece having a socket, including a distal opening providing access to a passage having a longitudinal axis, and first and second electrical contacts located therein, wherein the contacts are displaced along the longitudinal axis so the first contact is more distal than the second. Also, a surgical instrument includes an elongate shaft having distal and proximal ends, wherein an end effector at the distal end is for treating tissue. Further, a connecting portion includes third and fourth electrical contacts, wherein the contacts are displaced along the shaft so the third contact is more distal than the fourth. The surgical instrument is coaxially coupled to the handpiece by the connecting portion received in the passage, so the first contact is aligned with the third and the second is aligned with the fourth to provide an electrical power signal from the handpiece to the surgical instrument.

Abstract: An airflow health predictive maintenance system and method for a motor drive includes a differential pressure sensor that senses an air pressure differential between a sensing location within an enclosed cabinet space of the motor drive and a reference location. The system includes an electronic control system configured to select a setpoint that indicates that airflow through the cabinet space has reached a value associated with a need for air filter maintenance. The control system is further configured to obtain air pressure differential measurements periodically from the differential pressure sensor and generate an actual trend comprising a series of values, wherein each of the values of the actual trend is derived from one or more of the air pressure differential measurements.

Abstract: An electric pushback vehicle includes a frame having a forward portion and a rear portion. The vehicle further includes front drive axle and a rear drive axle configured to communicate power to ground engaging members. A traction battery is housed within the electric pushback vehicle and provides electric power to an electric motor to drive an output shaft. A transmission is connected to receive mechanical power from the electric motor through a torque converter.

Abstract: An incorrect copy of a record of data can be prevented from being transmitted to a distributed ledger system. A first file can be received and can include information, in audio or video form, with a description of a subject matter of the record of data and with an authorization to transmit the copy to the distributed ledger system. The first file can be sent to a device. A second file can be received from the device and can include information that confirms that the description of the subject matter, included in the first file, is correct, and that confirms that an entity, which controlled production of the first file, has permission to authorize causing the copy to be transmitted to the distributed ledger system. The correct copy can be caused, based on a receipt of the first and the second files, to be transmitted to the distributed ledger system.

Abstract: A system and method for displaying images of internal anatomy includes an image processing device configured to provide high resolution images of the surgical field from low resolution scans during the procedure. The image processing device digitally manipulates a previously-obtained high resolution baseline image to produce many representative images based on permutations of movement of the baseline image. During the procedure a representative image is selected having an acceptable degree of correlation to the new low resolution image. The selected representative image and the new image are merged to provide a higher resolution image of the surgical field. The image processing device is also configured to provide interactive movement of the displayed image based on movement of the imaging device, and to permit placement of annotations on the displayed image to facilitate communication between the radiology technician and the surgeon.

Abstract: This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and/or seedlings (e.g., cereal seeds and/or seedlings) with heterologous seed-derived bacterial endophytes.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A method and system are provided for enabling a shared augmented reality experience. The system may include one or more onsite devices for generating AR representations of a real-world location, and one or more offsite devices for generating virtual AR representations of the real-world location. The AR representations may include data and/or content incorporated into live views of a real-world location. The virtual AR representations of the AR scene may incorporate images and data from a real-world location and include additional AR content. The onsite devices may synchronize content used to create the AR experience with the offsite devices in real time, such that the onsite AR representations and the offsite virtual AR representations are consistent with each other.

Abstract: Embodiments described herein relate to suppressors for reducing or eliminating sound, flash, and/or heat generated by firearms while discharging projectiles. The suppressor includes a unitary structure containing a cone shaped nozzle disposed at one end of a body. The body has a plurality of baffles surrounding a central bore, a breech end opposite a faceplate, and a plurality of cooling channels spanning a length of the body. Each cooling channel has a first opening at the breech end and a second opening at the faceplate. The unitary structure further contains an outer ring spanning from the breech end to at least the faceplate, a longitudinal wall spanning from the breech end to the faceplate, and a plurality of radially oriented walls extending between the longitudinal wall and the outer ring. The plurality of cooling channels is disposed between the longitudinal wall, the outer ring, and the radially oriented walls.

Abstract: Systems and methods are described for establishing Proof of Location for a computing device (which may serve as Proof of Location for a user of the device). In some examples, establishing Proof of Location involves trackable features findable by the device at the location in question. In some examples, the computing device is configured to generate a point cloud of a trackable feature for comparison to a reference point cloud. Anti-spoofing methods are described for reducing the possibility of accidental or intentional false-positive Proof of Location results.

Abstract: Techniques are described for providing an interface for managing invitations to communicate via a communication platform. In an example, a first user can access a first interface to invite a second user to communicate via the communication platform. In response to input from the first user via the first interface, the communication platform can generate an invitation for the second user to communicate with the first user and can provide the invitation to the second user, such as by causing the invitation to be presented via a second interface. The second user can submit a response to the invitation via the second interface. The communication platform can update the first interface and the second interface based on response, such as, in examples in which the second user accepts the invitation, to reflect a newly established connection between the first user and the second user.