Abstract: An electronic communication network comprises a server platform and client data processing devices. Each client data processing device is configured to submit electronic messages to the server platform, provided with a timestamp. The server platform is configured to process incoming electronic messages strictly in a sequence corresponding to the timestamp. The electronic communication network comprising at least one switch, wherein the switch is arranged to receive electronic messages from a plurality of the client data processing devices. the switch comprises a buffer and is configured to store the electronic messages produced by the client data processing devices in the buffer, and to transfer the electronic messages in a manner sorted according to the timestamp provided to each electronic message by the time generator of the client data processing device submitting the electronic message, so that the electronic message with the oldest time is transferred first.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: This application relates to amatoxin analogs in which the trans-4-substituent on the proline residue of the amatoxin is an R group other than a hydroxy, constructs comprising such amatoxin analogs coupled to a linker and conjugates comprising such amatoxin analog-linker constructs conjugated to a target moiety. The application also relates to uses of such amatoxin analogs, for example, in treatment of cancer.

Abstract: In various examples, sensor data recorded in the real-world may be leveraged to generate transformed, additional, sensor data to test one or more functions of a vehicle—such as a function of an AEB, CMW, LDW, ALC, or ACC system. Sensor data recorded by the sensors may be augmented, transformed, or otherwise updated to represent sensor data corresponding to state information defined by a simulation test profile for testing the vehicle function(s). Once a set of test data has been generated, the test data may be processed by a system of the vehicle to determine the efficacy of the system with respect to any number of test criteria. As a result, a test set including additional or alternative instances of sensor data may be generated from real-world recorded sensor data to test a vehicle in a variety of test scenarios—including those that may be too dangerous to test in the real-world.

Abstract: An example method for cutting a plurality of lenticules from a donor cornea includes receiving a donor cornea, cutting a first layer of a first set of lenticules from the donor cornea, and cutting a second layer of a second set of lenticules from the donor cornea. The lenticules are cut according to a pattern that to maximizes the number of lenticules, thereby maximizing the number of implants from the single donor cornea. An example implant handling device includes a body. The body includes a flattened end configured to receive a corneal implant and keep the corneal implant from rolling or folding. The flattened end has a width and a height, the width being greater than the height. The body includes a slit opening to the flattened end, the slit opening configured to allow the corneal implant to pass into the flattened end.

Abstract: A storage/delivery device includes a first wall defining a well configured to receive a corneal tissue. The storage/delivery device includes a second wall configured to be positioned over the first wall and to seal the well. The second wall includes a recess configured to extend into the well to define a chamber between the first wall and the second wall. The chamber is configured to hold the corneal tissue when the second wall seals the well. A system may include the storage/delivery device above and a measurement system configured to measure the corneal tissue disposed in the well. In one example embodiment, the measurement system is an optical coherence tomography (OCT) system. In another example embodiment, the measurement system is a second-harmonic generation (SHG) or third-harmonic generation (THG) microscopy system.

Abstract: A storage/delivery device includes a first wall defining a well configured to receive a corneal tissue. The storage/delivery device includes a second wall configured to be positioned over the first wall and to seal the well. The second wall includes a recess configured to extend into the well to define a chamber between the first wall and the second wall. The chamber is configured to hold the corneal tissue when the second wall seals the well. A system may include the storage/delivery device above and a measurement system configured to measure the corneal tissue disposed in the well. In one example embodiment, the measurement system is an optical coherence tomography (OCT) system. In another example embodiment, the measurement system is a second-harmonic generation (SHG) or third-harmonic generation (THG) microscopy system.

Abstract: A powershift transmission for an agricultural machine includes a transmission housing, an input shaft unit and an output shaft, wherein the input shaft unit and the output shaft extend at least in sections within the transmission housing. An auxiliary shaft is arranged parallel to but offset between the input shaft unit and the output shaft. The input shaft unit and the auxiliary shaft are connected to one another via a front-mounted range unit, and the auxiliary shaft and the output shaft are connected to one another via a rear-mounted range unit. The front-mounted and rear mounted range units each includes at least two gear wheel pairs, the at least two gear wheel pairs being individually coupled or decoupled. The auxiliary shaft unit includes a first auxiliary shaft and a second auxiliary shaft, where the first and second auxiliary shafts are coupled to one another via a reduction gear unit.

Abstract: A method is provided for configuring different numbers of gearshift variants in a stepped powershift transmission for an agricultural working machine. The method includes providing a transmission unit, a front-mounted range unit, a gear reduction unit, a rear-mounted range unit, a housing, a drive shaft, a lay shaft, an output shaft, and a hydraulic control arrangement. The same transmission unit is used for all the numbers of gearshift variants while an identical spatial orientation of the shafts is maintained for all the numbers of gearshift variants. The method further includes adapting exclusively the gearshift variants by varying the front-mounted range unit or the rear-mounted range unit.

Abstract: An example method for cutting a plurality of lenticules from a donor cornea includes receiving a donor cornea, cutting a first layer of a first set of lenticules from the donor cornea, and cutting a second layer of a second set of lenticules from the donor cornea. The lenticules are cut according to a pattern that to maximizes the number of lenticules, thereby maximizing the number of implants from the single donor cornea. An example implant handling device includes a body. The body includes a flattened end configured to receive a corneal implant and keep the corneal implant from rolling or folding. The flattened end has a width and a height, the width being greater than the height. The body includes a slit opening to the flattened end, the slit opening configured to allow the corneal implant to pass into the flattened end.

Abstract: A powershift transmission for an agricultural machine includes a transmission housing, an input shaft and an output shaft unit. The input shaft and the output shaft unit extend at least at a distance within the transmission housing. The transmission also includes an auxiliary shaft arranged within the transmission housing and offset between the input shaft and the output shaft unit. The input shaft and the auxiliary shaft are connected to one another via a front-mounted range unit, and the auxiliary shaft and the output shaft unit are connected to one another via a rear-mounted range unit. Each range unit includes at least two individual gear wheel pairs which are coupled or decoupled. The output shaft unit includes a main output shaft and an auxiliary output shaft coupled to one another via a reduction gear unit.

Abstract: The present invention relates to a monochromator device. The monochromator device includes a first radiofrequency cavity positioned to receive an output beam from an electron source. A second radiofrequency cavity is positioned to receive the output beam from the first radiofrequency cavity. The first radiofrequency cavity and the second radiofrequency cavity are configured to, in combination, in combination, correct one or more energy deviations in time and space of the output beam.

Abstract: The invention relates to a stock exchange trading platform for a plurality of trader data processing devices that are in communication connection with the trading platform, wherein the trading platform has a trading platform data processing device (“matcher”), which is able to store orders generated by one of the trader data processing devices in an order book, or to fill a matching order that is already recorded in the order book, at least partially, to acknowledge such received orders to the dispatching trader data processing device, and furthermore, to send messages to a plurality of connected trader data processing devices (in the case of a trading system with equally entitled traders, to everybody) in a broadcast mode. The trading platform is in particular characterized in that a unit of the trading data processing device controlling the optional execution or storing of the orders is configured as a dedicated logic circuit.

Abstract: Methods, devices and program products are provided for managing a pacing therapy using an implantable medical device (IMD). The methods, devices and program products sense cardiac activity (CA) signals at electrodes located proximate to multiple left ventricular (LV) sites and a right ventricular (RV) site of the heart and utilizing one or more processors to measure activation times between the multiple LV sites and the RV site based on the CA signals. The processors program an order of activation for the multiple LV sites based on the activation times and identify an RV activation time and a septum activation time based on the CA signals. The processors calculate a septum to RV activation time (SRAT) based on the RV and septum activation times and program an AVSRAT delay based on the SRAT.

Abstract: Methods, devices and program products are provided for managing a pacing therapy using an implantable medical device (IMD). The methods, devices and program products sense cardiac activity (CA) signals at electrodes located proximate to multiple left ventricular (LV) sites and a right ventricular (RV) site of the heart and utilizing one or more processors to measure activation times between the multiple LV sites and the RV site based on the CA signals. The processors program an order of activation for the multiple LV sites based on the activation times and identify an RV activation time and a septum activation time based on the CA signals. The processors calculate a septum to RV activation time (SRAT) based on the RV and septum activation times and program an AVSRAT delay based on the SRAT.

Abstract: A method for shifting a PTO transmission includes selecting a PTO output speed from one of a first PTO speed and a second PTO speed of the PTO transmission, operating the PTO transmission in a reduced power mode at the selected PTO speed, the reduced power mode providing lower power to the PTO transmission at the selected PTO speed than a normal operating mode, comparing an instantaneous drive power to a maximum drive power in the reduced power mode, and when the instantaneous drive power exceeds the maximum drive power, automatically shifting the PTO transmission under load from the reduced power mode to the normal operating mode and automatically adjusting a transmission ratio of a vehicle transmission.

Abstract: Systems and methods produce implants for treating keratoconus or other eye disorders. An example method includes identifying a subject with keratoconus. The method includes obtaining, with assessment means, an assessment of a cornea of a subject; determining, by processor(s), inverse measurements for correcting one or more irregularities associated with the keratoconus based on the assessment; and shaping, with a laser system, a donor cornea according to a pattern based on the inverse measurements. The example method may further include determining smoothing effects associated with the cornea, wherein the inverse measurements are based further on the smoothing effects, and the pattern for shaping the donor cornea is based further on the smoothing effects.

Abstract: In a method for manufacturing an electric motor comprising a rotor and a stator a placeholder for a temperature sensor is inserted in the axial direction between a first coil layer and an adjacent second coil layer of a winding head such that the placeholder is situated in a gap-shaped recess extending between the first and the second coil layers, the first coil layer is then pressed onto a circumferential surface of the placeholder and onto the second coil layer and is plastically deformed such that a space between the lateral surfaces of the two coil layers and the circumferential surface of the placeholder is reduced, and a contact surface between the lateral surface of the first coil layer and the circumferential surface of the placeholder is enlarged. By removing the placeholder, a receiving chamber is subsequently formed in the winding head, into which a temperature sensor is then inserted.

Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

Abstract: A system for forming a corneal implant includes a cutting apparatus, which includes a laser source that emits a laser and optical elements that direct the laser. The system includes a controller implemented with at least one processor and at least one data storage device. The controller generates a sculpting plan for modifying a first shape of a lenticule formed from corneal tissue and achieving a second shape for the lenticule to produce a corneal implant with a refractive profile to reshape a recipient eye. The sculpting plan is determined from measurements relating to the lenticule having the first shape and information relating to a refractive profile for a corneal implant. The controller controls the cutting apparatus to direct, via the one or more optical elements, the laser from the laser source to sculpt the lenticule according to the sculpting plan to produce the corneal implant with the refractive profile.