Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: A robotic catheter procedure system includes a bedside system that has a percutaneous device, and an actuating mechanism configured to engage and to impart movement to the percutaneous device. The system also includes a workstation coupled to the bedside system. The workstation includes a user interface configured to receive a user input, ma display device configured to display an image, a control system operatively coupled to the user interface and the actuating mechanism. The control system is configured to generate a control signal and the actuating mechanism causes movement of the percutaneous device in response to the control signal. The control system is configured to slow movement of the percutaneous device via the actuating mechanism as an identified point on the percutaneous device approaches a structure requiring a change in direction of the percutaneous device.

Abstract: A phosphor composition includes an activated uranium-based phosphor having formula I or II. The phosphor is doped with Eu3+ [Ba1?a?bSraCab]x[Mg,Zn]y(UO2)z([P,V]O4)2(x+y+z)/3??(I) [Ba1?a?bSraCab]p(UO2)q[P,V]rO(2p+2q+5r)/2??(II) where 0?a?1, 0?b?1, 0.75?x?1.25, 0.75?y?1.25, 0.75?z?1.25, 2.5?p?3.5, 1.75?q?2.25, and 3.5?r?4.5 and formula II excludes the combination where a is 0, b is 0, p is 3.5, q is 1.75, and r is 3.5. Phosphor compositions further including formula VI or other luminescent materials, such as quantum dots, devices and displays are also provided.

Abstract: A sheath assembly for the insertion of a percutaneous pump includes a tubular sheath body dimensioned for insertion into a blood vessel through a vessel aperture. The tubular sheath body includes a wall having a proximal end portion, a distal end portion, a longitudinal axis, an outer surface, an inner surface defining a first lumen substantially parallel to the longitudinal axis, and a second lumen disposed within the wall between the inner surface and the outer surface and extending from the proximal end portion to the distal end portion. The first lumen is dimensioned to allow passage of a portion of the percutaneous pump, and the second lumen is dimensioned for passage of a guidewire. A stylet is removably positioned to substantially occlude the second lumen. The stylet has a proximal end releasably secured to the sheath assembly.

Abstract: Technologies are disclosed for shortening and/or minimizing service interruptions. An incident service executing within a service provider network is used to detect an incident that has caused a service interruption and performs operations to assist in resolving the service interruption. The incident service may identify resources (e.g., computing resources, individuals, . . . ) to triage and remediate the service interruption. For instance, the incident service may provide information to one or more users of a customer experiencing a service interruption to assist in guiding the user(s) to address one or more problems to assist in resolving the service interruption. The information may include information such as providing one or more recommendations to configure one or more services, such as one or more actions to perform (e.g., a step-by-step runbook).

Abstract: Stents and/or implants including a reinforcement member. An illustrative transluminal implant may include an elongated tubular body extending from first end region to a second end region. The elongated tubular body may comprise a scaffolding forming a plurality of cells, a first flange adjacent to the first end region, a second flange adjacent to the second end region, and a saddle region extending between the first flange and the second flange. The saddle region may have an outer diameter less than an outer diameter of the first flange and the second flange. A reinforcement member may be disposed within a lumen of the elongated tubular body and within the first flange.

Abstract: The present disclosure provides alert implants that comprise a medical device and an implantable reporting processor (IRP), where one example of such a medical device includes a component for a total knee arthroplasty (TKA) such as a tibial extension, a femoral component for hip replacements, a breast implant, a distal rod for arm or leg breakage repair, a scoliosis rod, a dynamic hip screw, a spinal interbody spacer, and tooling and methods that may be used to form the alert implant, and uses of such alert implants in the health maintenance of patients who receive the implant.

Abstract: Systems and methods of mitigating a contact weld of a first relay for selectively transmitting power to a first heating element of a water heating system. One method includes providing a signal to open the first relay, determining, following providing the signal to open the first relay, a first temperature measurement of a portion of a fluid within a tank of the water heating system via a temperature sensor, determining whether a difference between the first temperature measurement and a first target setpoint exceeds a first predetermined threshold, and activating, in response to the difference between the first temperature measurement and the first target setpoint exceeding the first predetermined threshold, a vibration device for a predetermined time period, the vibration device being positioned such that a resulting vibration from an activation of the vibration device is transmitted to the first relay.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: A method for forming a semiconductor device can include coating a reversible overcoat layer over first mandrels on a substrate, inducing a crosslinking reaction within the reversible overcoat layer that renders the reversible overcoat layer insoluble to a developer and forms a crosslinked overcoat layer, diffusing acid particles from the first mandrels into first portions of the crosslinked overcoat layer, inducing a de-crosslinking reaction within the first portions of the crosslinked overcoat layer to form de-crosslinked regions, where unmodified regions of the crosslinked overcoat layer form second mandrels, and selectively removing the de-crosslinked regions with the developer such that the first mandrels and the second mandrels form a mandrel pattern over the substrate, where the developer has a solubility distance in a range of zero to seven in a Hansen Solubility Parameter space relative to methyl isobutyl carbinol.

Abstract: Aspects of the present disclosure provide a wafer processing device for optimizing wafer shape. For example, the wafer processing device can include a first hot plate, a second hot plate and a controller. The first hot plate can be configured to heat a wafer. For example, the first hot plate can provide uniform heating across a surface of the first hot plate. The second hot plate has multiple heating zones with each heating zone independently controllable such that each heating zone can be set to a temperature value independent of other heating zones. The controller is configured to control the first hot plate to provide the uniform heating, receive a bow measurement from wafer curvature measurement of a wafer, and set the multiple heating zones of the second hot plate to their respective temperature values that correspond to the bow measurement.

Abstract: A method for molding a seamless rebonded foam article with an internal cavity is provided. The method may include moving a middle mold to a middle mold form position within the mold cavity to press into a first portion of rebond foam particles, and moving a top mold to a top mold form position within the mold cavity to press into the second portion of rebond foam particles. The method may further include injecting steam into the mold cavity at a middle mold fluid port interface of the middle mold such that the steam passes into the mold cavity to interact with the first and second portions of rebond foam particles via at least one middle mold flow hole in the middle mold, and evacuating the steam via a vacuum source coupled to the top mold and the bottom mold.

Abstract: A method includes receiving, with a computing device, a first client request from a first client that identifies a machine learning model and a sensor. The method includes sending, with the computing device, a call to a server to apply the identified machine learning model to a set of data from the identified sensor, in response to the first client request. The method includes receiving, with the computing device, a second client request from a second client that identifies a same machine learning model and sensor as the first client request. The method includes sending, with the computing device, response data from the identified machine learning model to both the first client and the second client without sending an additional call to the server in response to the second client request.

Abstract: Systems, methods, and corresponding computer-readable media for multi-modal hierarchical semantic search of electronic documents. Systems in accordance with the disclosure comprise search engine controllers, any desired numbers of search engine interface controllers, and persistent data stores accessible by the search engine controllers. The controllers are configured to parse searchable document data sets to extract document object data sets. Each document object data set can represent textual and/or image feature of the document. For each document object data sets the controller generates at least one enriched document object data set, and forms at least one of a document graph or index. In response to search requests, the search controller compares document graphs or indexes to identify the most similar documents.

Abstract: Techniques are described herein for evaluating user activities on a website for detecting and alerting anomalies with the website. For example, an alerting system may determine a set of time-windows for each of a set of attribute value(s) and use a set of performance metrics and/or web session events for the time-windows from historical web sessions to detect an anomaly in a current time-window. The alerting system may determine an evaluation range based on weighted performance ranges, and alert a client indicating a performance anomaly if a performance metric at the time of evaluation are out of the evaluation range. Attribute value(s) related to a website issue can be identified based on a correlated to anomalous web session events or to an anomalous time-window.

Abstract: Techniques are described herein for evaluating user activities on a website for detecting and alerting anomalies with the website. For example, an alerting system may determine a set of time-windows for each of a set of attribute value(s) and use a set of performance metrics and/or web session events for the time-windows from historical web sessions to detect an anomaly in a current time-window. The alerting system may determine an evaluation range based on weighted performance ranges, and alert a client indicating a performance anomaly if a performance metric at the time of evaluation are out of the evaluation range. Attribute value(s) related to a website issue can be identified based on a correlated to anomalous web session events or to an anomalous time-window.

Abstract: An example robot performs a scan to obtain image data of a given region. The robot performs image analysis on the image data to detect a set of undesirable objects, and generates a reference map that excludes the set of undesirable objects, where the reference map is associated with the location of the robot at the time of the scan.

Abstract: Examples of neural networks trained for multiple tasks are described herein. In some examples, a method may include determining a feature vector using a first portion of a neural network. In some examples, the neural network is trained for multiple tasks. Some examples of the method may include transmitting the feature vector to a remote device. In some examples, the remote device is to perform one of the multiple tasks using a second portion of the neural network.

Abstract: An example control system includes a memory and at least one processor to obtain image data from a given region and perform image analysis on the image data to detect a set of objects in the given region. For each object of the set, the example control system may classify each object as being one of multiple predefined classifications of object permanency, including (i) a fixed classification, (ii) a static and fixed classification, and/or (iii) a dynamic classification. The control system may generate at least a first layer of a occupancy map for the given region that depicts each detected object that is of the static and fixed classification and excluding each detected object that is either of the static and unfixed classification or of the dynamic classification.