Patents by Inventor David A. Muthard

David A. Muthard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-(heterocyclylheteroaryliumalkyl) phenyl carbapenem antibacterial agents
    Patent number: 5362723
    Abstract: Carbapenems having the formula: ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. DiNinno, Thomas N. Salzmann, David A. Muthard
  • 2-(quinoliniumalkyl and isoquinoliniumalkyl) phenyl carbapenem antibacterial agents
    Patent number: 5124323
    Abstract: Carbapenems having the formula: ##STR1## In which Q.sup.+ is quinolinium or isoquinolinium, are useful antibacterial agents.
    Type: Grant
    Filed: July 17, 1991
    Date of Patent: June 23, 1992
    Assignee: Merck
    Inventors: Frank P. DiNinno, Thomas N. Salzmann, David A. Muthard
  • 2-(Heteroaryliumalkyl)phenyl carbapenem antibacterial agents
    Patent number: 4978659
    Abstract: Carbapenems having the formula: ##STR1## are useful antibacterial agents.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: December 18, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. DiNinno, David A. Muthard, Thomas N. Salzmann
  • 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids
    Patent number: 4675317
    Abstract: Disclosed are 6- and 6,6-disubstituted-2-substituted thio-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from: hydrogen; substituted and unsubstituted: alkyl, cycloalkyl, halo, alkoxyl, alkenyl, aralkyl, aryl, heterocyclyl, heteroaryl, and heterocyclylalkyl; W is an electron withdrawing group, and, for example, is selected from: --COR.sup.5, --CN, SO.sub.2 C.sub.6 H.sub.5 ; R.sup.5 is hydrogen; substituted and unsubstituted: alkyl, aryl, aralkyl, heteroaryl, heterocyclyl, or heterocyclylalkyl; or R.sup.5 may be --OR.sup.6, --NR.sup.7 R.sup.8, and --SR.sup.9 ; wherein R.sup.6 is H; substituted and unsubstituted: alkyl, alkenyl, or a group which defines --CO.sub.2 R.sup.6 as a pharmaceutically acceptable ester wherein R.sup.6 is, for example, phthalidyl, or 5-methyl-2-oxo-1,3-dioxolen-4-ylmethyl; R.sup.7 and R.sup.
    Type: Grant
    Filed: January 25, 1983
    Date of Patent: June 23, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Frank P. DiNinno, William J. Leanza, Ronald W. Ratcliffe, David A. Muthard
  • 6-Amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids
    Patent number: 4388310
    Abstract: Disclosed are 6-amido-2-S-oxides of substituted 2-organothio-pen-2-em-3-carboxylic acids (I) which are useful as antibiotics and as intermediates in the synthesis of substituted pen-2-em-3-carboxylic acids: ##STR1## wherein: R.sup.1 is H or acyl; R.sup.2 is hydrogen or methoxyl; R.sup.3 is alkyl having from 1-6 carbon atoms; phenylalkyl having 7-12 carbon atoms; and cycloalkyl having 3-6 carbon atoms; and R.sup.4 is hydrogen, a removable protecting group or a pharmaceutically acceptable salt or ester moiety.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: June 14, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, Frank P. DiNinno, David A. Muthard, Ronald W. Ratcliffe