Abstract: A system and method for processing e-mail is provided wherein an e-mail is received from an originator or a customer, a routing destination is determined and responses to the e-mail are retrieved from a library based on the selected routing destination. Customer data is then accessed and the responses are filtered based on customer information that is extrinsic to the e-mail. An agent can select a response from the list of filtered responses and the selected response can be sent to the originator.

Abstract: The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.

Abstract: The described invention relates to a method for determining corrosion in wet gas pipelines comprising: a) using a portion of the liquid phase from a wet gas pipeline; b) placing said portion in a high pressure, high temperature autoclave to prepare a saturated vapor phase; c) transferring the saturated vapor to a corrosion test unit, said unit having a specimen holder section having external, temperature adjustable means, and specimens being arranged in one or more positions within the specimen holder; d) chilling said specimen holder section so as to cause condensation onto said corrosion testing specimens; and, e) calculating a value selected from the group consisting of corrosions rate, pitting of the specimen, weight loss of the specimen, and any combination thereof. The invention process can be practiced in a separate laboratory apparatus designed to accomplish the above method, or in a similar online apparatus set up in a semi-batch mode or continuous mode.

Abstract: The present invention relates to a method of identifying a haematopoietic stem cell (HSC) or progeny thereof comprising the steps of: obtaining a cell sample including HSC or progeny thereof; detecting the presence of at least one carbohydrate sequence having a sequence of at least one disaccharide repeat of glucuronic acid and N-acetylglucosamine or an equivalent thereof; and identifying a HSC or progeny thereof having the sequence or equivalent thereof. The invention also relates to methods of enriching cell populations for HSC or progeny thereof, for isolating HSC or progeny thereof and cell preparations obtained using the methods of their invention and their uses.

Abstract: The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.

Abstract: The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.

Abstract: Methods and apparatus utilized to form foam pigs in-situ are provided. The in-situ generated foam pigs may be used for a number of purposes, including, but not limited to, commissioning or operational pigging. Further, the in-situ generated foam pigs may be used in a variety of type flowlines, including, but not limited to production or transportation pipelines used to carry hydrocarbons from subsea wells over long distances.

Abstract: The present invention provides a method for selecting hematopoietic stem cells (HSCs) comprising providing an agent which binds to ?9?1 integrin on the cell surface to a population of cells including HSCs and separating HSCs by virtue of the binding agent. The invention also provides a method of culturing a population of HSCs in the presence of an agent which binds to ?9?1, wherein the agent inhibits differentiation of the HSCs. The invention also provides a method of producing a population of lineage committed cells comprising culturing HSCs in the presence of an agent which inhibits or prevents binding to ?9?1.

Abstract: Disclosed is a multistable structural member (10), of use in various structural applications. The member (10) has a sheet form. In a first configuration (e.g. open configuration), a first distribution of stored elastic stresses is counterbalanced against at least two reinforcing corrugations (12). In a second configuration (e.g. rolled configuration), these corrugations (12) are deformed to provide a second, different distribution of stored elastic stresses counterbalanced by the shape of the member in the second configuration. The first and second configurations are stable but reversibly interchangeable. An external force is required to cause a transformation between the first and second configurations. The member may be formed by suitable plastic deformation of a metallic sheet. A method for forming such a multistable structural member (10), a multistable structure an a multistable assembly (3), having a plurality of multistable members are also disclosed.

Abstract: A construction set for constructing a user-definable apparatus. for example a robot, is provided with one or more construction set components. The components may include components that are reconfigurable into other construction set components, and that have at least one demarcation defining adjacent segments thereof. The demarcations facilitate reconfiguration of the construction set components to produce other construction set components. The construction set may include an electromechanical drive assembly having an integrated speed control and operable to receive interchangeable. non-circular drive shafts. The electromechanical drive assembly may be configured to attach to and self-align relative to other construction set components. One or more of the components may be provided with openings through which the non-circular drive shafts may rotate. The drive shaft may be locked in relation to openings of components that allow the drive shaft to rotate via a lock plate. A bearing plate may also be included.

Abstract: Two-post rack systems may be adapted to support four-post rack mounted equipment. In one implementation, the system includes a coupling member for modifying a two-post equipment rack. The coupling member may include a vertical support member with first and second lateral ends and first and second longitudinal ends. A first torsion member may be coupled to the vertical support member at the first longitudinal end, and a second torsion member may be coupled to the vertical support member at the second longitudinal end. A coupling feature on the torsion members may be included to allow coupling to adjacent coupling members. An equipment attachment flange may be coupled to the first lateral end, and may further be adapted to emulate a vertical upright in a four-post rack.

Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.

Abstract: The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.

Abstract: The present invention provides methods, culture media, and apparatus to produce useful amounts of specific cell populations ex vivo by the modulation of Opn and/or an active Opn fragment. The present invention provides ex vivo expanded populations of HSC for use in transplantation therapy and in clinical and research activities, such as drug screening, toxicity testing, and other research activities. Also provided are methods, devices and culture media are provided to inhibit Opn binding to HISC to promote the increased production of more differentiated cell populations.

Abstract: A system and method for operating robots in a robot competition. One embodiment of the system may include operator interfaces, where each operator interface is operable to control movement of a respective robot. A respective operator interface may be in communication with an associated operator radio, where each radio may have a low power RF output signal. A robot controller may be coupled to each robot in the robot competition. A robot radio may be coupled to a respective robot and in communication with a respective robot controller and operator radio. The robot radios may have a low power RF output signal while communicating with the respective operator radios. Alternatively, the radios may be short range radios, where a distance of communication may be a maximum of approximately 500 feet.

Abstract: A pump for a combustion engine is disclosed. The pump may have at least one pumping member movable through a plurality of displacement strokes during a single engine cycle. The pump may also have a controller in communication with the pumping member. The controller may be configured to selectively reduce an amount of fluid displaced during at least one, but less than all of the plurality of displacement strokes. The reduction may be initiated in response to a demand for the displaced fluid.

Abstract: A system and method for operating robots in a robot competition. One embodiment of the system may include operator interfaces, where each operator interface is operable to control movement of a respective robot. A respective operator interface may be in communication with an associated operator radio, where each radio may have a low power RF output signal. A robot controller may be coupled to each robot in the robot competition. A robot radio may be coupled to a respective robot and in communication with a respective robot controller and operator radio. The robot radios may have a low power RF output signal while communicating with the respective operator radios. Alternatively, the radios may be short range radios, where a distance of communication may be a maximum of approximately 500 feet.

Abstract: The use of laser shock processing in oil & gas and/or petrochemical applications is provided by the present invention. The use includes subjecting friction stir weldments, fusion weldments, and other critical regions of ferrous and non-ferrous alloy components used in oil & gas and petrochemical applications to laser shock processing to create residual compressive stresses near the surface of the treated area. The residual compressive forces in the ferrous or non-ferrous components improve properties including, inter alia, is surface strength, fatigue life, surface hardness, stress corrosion resistance, fatigue resistance, and environmental cracking resistance. Laser shock processing finds particular application in high strength pipelines, steel catenary risers, top tension risers, threaded components, liquefied natural gas containers, pressurized liquefied natural gas containers, deep water oil drill strings, riser/casing joints, and well-head equipment.

Abstract: The use of friction stir and laser shock processing in oil & gas and/or petrochemical applications is provided by the present invention. The use includes subjecting friction stir weldments, fusion weldments, and other critical regions of ferrous and non-ferrous alloy components used in oil & gas and petrochemical applications to laser shock processing to create residual compressive stresses near the surface of the treated area. The residual compressive forces in the ferrous or non-ferrous components improve properties including, inter alia, surface strength, fatigue life, surface hardness, stress corrosion resistance, fatigue resistance, and environmental cracking resistance. Friction stir and laser shock processing find particular application in high strength pipelines, steel catenary risers, top tension risers, threaded components, liquefied natural gas containers, pressurized liquefied natural gas containers, deep water oil drill strings, riser/casing joints, and well-head equipment.

Abstract: The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors.