Patents by Inventor David A. Orlando

David A. Orlando has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS
    Publication number: 20230042181
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Application
    Filed: July 22, 2022
    Publication date: February 9, 2023
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael Robert McKeown, David A. Orlando
  • Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists
    Patent number: 11447831
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: September 20, 2022
    Assignee: Syros Pharmaceuticals, Inc.
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael Robert McKeown, David A. Orlando
  • METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS
    Publication number: 20200392583
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Application
    Filed: May 8, 2020
    Publication date: December 17, 2020
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael Robert McKeown, David A. Orlando
  • Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists
    Patent number: 10697025
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: June 30, 2020
    Assignee: Syros Pharmaceuticals, Inc.
    Inventors: Mei W. Chen, Cindy Collins, Matthew L. Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael R. McKeown, David A. Orlando
  • Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists
    Patent number: 10167518
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: January 1, 2019
    Assignee: Syros Pharmaceuticals, Inc.
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael R. Mckeown, David A. Orlando
  • METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS
    Publication number: 20180187271
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Application
    Filed: February 20, 2018
    Publication date: July 5, 2018
    Inventors: Mei W. Chen, Cindy Collins, Matthew L. Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael R. McKeown, David A. Orlando
  • METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS
    Publication number: 20180087115
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Application
    Filed: October 31, 2017
    Publication date: March 29, 2018
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael R. McKeown, David A. Orlando
  • Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists
    Patent number: 9845508
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: December 19, 2017
    Assignee: Syros Pharmaceuticals, Inc.
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael R. McKeown, David A. Orlando
  • METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS
    Publication number: 20160355888
    Abstract: The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Inventors: Mei Wei Chen, Cindy Collins, Matthew Lucas Eaton, Matthew G. Guenther, Nan Ke, Jeremy Lopez, Michael R. McKeown, David A. Orlando
  • METHODS AND SYSTEMS FOR EVALUATING GENES
    Publication number: 20160032387
    Abstract: Aspects and embodiments disclosed herein are directed to providing methods and systems for evaluating target genes and/or associated super enhancers and or super-enhance components. In some embodiments, the method includes selecting a gene associated with a super-enhancer, to provide a selected gene, evaluating the selected gene for contribution to a cell state, e.g., a state characterized by a disease or disorder (a disease/disorder state), and responsive to the evaluation, classifying the selected gene and/or associated super-enhancer.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Inventors: Christian C. Fritz, David A. Orlando, Matthew G. Guenther, Jakob Loven, Peter B. Rahl, Charles Y. Lin
  • REGULATORY POLYNUCLEOTIDES AND USES THEREOF
    Publication number: 20150033407
    Abstract: The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 29, 2015
    Inventors: Tedd D. Elich, Philip N. Benfey, Ai-Jiuan Wu, David A. Orlando, Ian Davis
  • REGULATORY POLYNUCLEOTIDES AND USES THEREOF
    Publication number: 20140331358
    Abstract: The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.
    Type: Application
    Filed: April 9, 2014
    Publication date: November 6, 2014
    Applicant: Monsanto Technology LLC
    Inventors: Tedd D. Elich, Philip N. Benfey, Ai-Jiuan Wu, David A. Orlando, Ian Davis
  • Regulatory polynucleotides and uses thereof
    Patent number: 8816152
    Abstract: The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 26, 2014
    Assignee: Monsanto Technology LLC
    Inventors: Tedd D. Elich, Philip N. Benfey, Ai-Jiuan Wu, David A. Orlando, Ian Davis
  • REGULATORY POLYNUCLEOTIDES AND USES THEREOF
    Publication number: 20140230093
    Abstract: The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.
    Type: Application
    Filed: July 18, 2012
    Publication date: August 14, 2014
    Inventors: Tedd D. Elich, Philip N. Benfey, Ian Davis, David A. Orlando
  • REGULATORY POLYNUCLEOTIDES AND USES THEREOF
    Publication number: 20120284880
    Abstract: The present disclosure provides compositions and methods for regulating expression of transcribable polynucleotides in plant cells, plant tissues, and plants. Compositions include regulatory polynucleotide molecules capable of providing expression in plant tissues and plants. Methods for expressing polynucleotides in a plant cell, plant tissue, or plants using the regulatory polynucleotide molecules disclosed herein are also provided.
    Type: Application
    Filed: June 20, 2012
    Publication date: November 8, 2012
    Inventors: Tedd D. Elich, Philip N. Benfey, Al-Jiuan Wu, David A. Orlando, Ian Davis