Abstract: The present invention relates to the use of (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of formula (I), prefer-ably in form of one of its salts or solvates or hydrates, preferably (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid in form of monohydrate (I) of formula (I-M-I) or (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)-ethyl]-amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid inform of mono hydrate (II) of formula (I-M-II), in the inhalative treatment of cardiopulmonary and pulmonary disorders, such as pulmonary arterial hypertension (P AH), chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension (PH) associated with chronic lung disease (PH group 3) such as pulmonary hypertension in chronic obstructive pulmo

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A system and method for managing raw files are disclosed. A plurality of image files associated with one or more raw files that include respective metadata are evaluated. A set of one or more of the images files are grouped together based on matching the respective metadata. An asset file corresponding to the raw file and the grouped set of the image files are generated. The asset file are retrieved in response to a request from a user device. At least one of the image files in the grouped set are selected and a display of the selected image file is generated for rendering.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A method of estimating a load on a vehicle (10), the method comprising: obtaining a first load estimate using a first load estimation technique; obtaining a second load estimate using a second load estimation technique; analysing characteristics of the first load estimate and the second load estimate; and, based on the analysis selecting either the first load estimate or the second load estimate as an output load estimate.

Abstract: A method of estimating a load on a vehicle (10), the method comprising: obtaining a first load estimate using a first load estimation technique; obtaining a second load estimate using a second load estimation technique; analysing characteristics of the first load estimate and the second load estimate; and, based on the analysis selecting either the first load estimate or the second load estimate as an output load estimate.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Embodiments disclosed herein generally relate to a method, system, and computer readable medium for generating a thumbnail for a media file. A web client application server receives the media file having metadata associated therewith. The web client application server generates an interest point area. The interest point area includes one or more interest points in the media file. The web client application server aligns a thumbnail area with respect to the interest point area. The web client application server displays a portion of the media file in the thumbnail area. The portion of the media file that is displayed includes at least a portion of the interest point area.

Abstract: A controller for a motor vehicle includes means for receiving information indicative of a current vehicle speed; means for receiving information indicative of an amount of brake force a braking system is developing or is capable of developing; means for receiving information indicative of a gradient of a driving surface on which the vehicle is driving; and torque transmission reduction means for causing a powertrain torque reduction operation to be performed in which the controller causes one or more components in a torque transmission path from a torque delivery device to driven wheels to assume a torque reduction condition in which torque transmission is reduced or substantially terminated. The controller is configured automatically to cause the torque reduction operation to be performed in dependence at least in part on the information indicative of current vehicle speed, information indicative of brake force amount and information indicative of driving surface gradient.

Abstract: A first elongate member and a second elongate member of a collapsible joint may each be pivotally engaged with at least one connecting member. A first locking pin may be positioned within aligned openings in the first elongate member and the at least one connecting member in a first engaged position. A second locking pin may be positioned within openings in the second elongate member and the at least one connecting member in a second engaged position. When the first locking pin is in the first engaged position and the second locking pin is in the second engaged position, the first elongate member may be substantially coaxial with the second elongate member.

Abstract: Embodiments disclosed herein generally relate to a method, system, and computer readable medium for generating a thumbnail for a media file. A web client application server receives the media file having metadata associated therewith. The web client application server generates an interest point area. The interest point area includes one or more interest points in the media file. The web client application server aligns a thumbnail area with respect to the interest point area. The web client application server displays a portion of the media file in the thumbnail area. The portion of the media file that is displayed includes at least a portion of the interest point area.

Abstract: Embodiments of the present invention provide a controller for a motor vehicle comprising: means for receiving information indicative of a current vehicle speed; means for receiving information indicative of an amount of brake force a braking system of the vehicle is developing or is capable of developing; means for receiving information indicative of a gradient of a driving surface on which the vehicle is driving; and torque transmission reduction means for causing a powertrain torque reduction operation to be performed in which the controller causes one or more components in a torque transmission path from a torque delivery device to driven wheels of the vehicle to assume a torque reduction condition in which torque transmission from the torque delivery device to the driven wheels is reduced or substantially terminated, the controller being configured automatically to cause the torque reduction operation to be performed in dependence at least in part on the information indicative of current vehicle speed, in

Abstract: The present invention relates to a control module (62) for controlling an automatic gearbox (58). The control module comprises (62) a monitoring module (70) for monitoring one or more parameters of at least one powertrain element. The control module (62) also comprises a determining module arranged to determine a temperature of a powertrain component based on said one or more monitored parameters. The control module (62) also comprises a driving module (60) arranged to detect a driving condition of the vehicle. The control module (62) also comprises an output module (74) arranged to output a downshift command (76) to the automatic gearbox (58) in dependence on the driving condition of the vehicle and on the temperature of the powertrain component exceeding a predetermined threshold, wherein the downshift command selects a gear higher than first gear.

Abstract: Techniques for determining one or more heat transfer characteristic values of a structure, such as an electronic device, are disclosed. A heat flux vector magnitude and a temperature gradient vector magnitude for a portion of the structure are determined, and a product of the heat flux vector magnitude with the temperature gradient vector magnitude is obtained. More particularly, the dot product of the heat flux vector magnitude with the temperature gradient vector magnitude may be obtained to provide a bottleneck heat transfer characteristic value. Alternately or additionally, a cross product (or related operation) of the heat flux vector magnitude with the temperature gradient vector magnitude is obtained to produce a shortcut heat transfer characteristic value.

Abstract: In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.

Abstract: A wearable wound simulant for simulating a battlefield wound is presented. The simulant facilitates a graphically and functionally realistic medical training tool. The simulant includes a skin replica and a wound. The skin replica is shaped to conformably contact and cover a body region either in part or whole. The skin replica further includes a plurality of bendable layers arranged to approximately replicate the visual and tactile properties of human tissue and at least one tear resistant layer composed of a fabric material disposed between two bendable layers. At least one tear resistant layer is less stretchable than the elastic limit of the bendable layers so as to prevent failure thereof. The bendable and tear resistant layers form a self-sealing structure. A three-dimensional wound structure is disposed along the skin replica so as to replicate the appearance and functionality of a penetrating or non-penetrating injury.

Abstract: A novel process for preparing a compound of formula (I) which comprises converting a compound of formula (II) to a compound of formula (I) via a compound of formula (III), or a salt thereof, without isolating any intermediates.

Abstract: A wearable wound simulant for simulating a battlefield wound is presented. The simulant facilitates a graphically and functionally realistic medical training tool. The simulant includes a skin replica and a wound. The skin replica is shaped to conformably contact and cover a body region either in part or whole. The skin replica further includes a plurality of bendable layers arranged to approximately replicate the visual and tactile properties of human tissue and at least one tear resistant layer composed of a fabric material disposed between two bendable layers. At least one tear resistant layer is less stretchable than the elastic limit of the bendable layers so as to prevent failure thereof. The bendable and tear resistant layers form a self-sealing structure. A three-dimensional wound structure is disposed along the skin replica so as to replicate the appearance and functionality of a penetrating or non-penetrating injury.

Abstract: This invention relates to the printing of a substrate having a pre-printed “print pattern” with a “design layer” of ink where there is differential adhesion within and without the print pattern. The print pattern is receptive to an ink, and the design layer ink forms a durable image material with good bond to the print pattern, but the ink does not form a durable image material on the portions of the substrate outside the print pattern. The design layer ink is a UV-curable ink, and the print pattern may have a higher surface energy than the portions of the substrate outside the print pattern.