Abstract: An adjustable vehicle loading ramp system that removably cooperates with a vehicle mounted hitch receiver and provides a rearward directed supplemental hitch receiver. The loading ramp system includes a pair of ramp sections that are movably connected to a mounting system to provide a plurality of lateral distances between the respective ramp sections. The assembly is stowable to achieve a compact orientation of the loading ramp system relative to a tailgate of a vehicle and an in-use position wherein the ramp sections can be deployed to provide a supported incline into the bed or cargo area of the underlying vehicle.

Abstract: An adjustable vehicle loading ramp system that removably cooperates with a vehicle mounted hitch receiver and provides a rearward directed supplemental hitch receiver. The loading ramp system includes a pair of ramp sections that are movably connected to a mounting system to provide a plurality of lateral distances between the respective ramp sections. The assembly is stowable to achieve a compact orientation of the loading ramp system relative to a tailgate of a vehicle and an in-use position wherein the ramp sections can be deployed to provide a supported incline into the bed or cargo area of the underlying vehicle.

Abstract: Peptide constructs comprised of multideterminant T helper peptides from the envelope glycoprotein of HIV previously identified to induce proliferative responses in four different haplotypes of mice and IL-2 responses in 52-73% of HIV positive, flu positive patients (cluster peptides), were co-linearly synthesized with the peptide 18 of the V3 loop of HIV-1 gp 160, corresponding to the principal neutralizing determinant of HIV-IIIB and also shown to contain a dominant CTL epitope. Cognate help for peptide 18 antibody was elicited following a single immunization in all strains of mice which had previously responded to a T cell epitope encompassed by the peptides. In two strains of mice, the level of neutralizing antibody achieved was comparable to levels adequate for protection from homologous viral challenge in chimpanzees. After a single boost, much higher antibody titers for 90% neutralization in the range of 1:1000 to 1:16,000 were achieved.

Abstract: A drop tube segment includes a conduit with a first end portion and a second end portion. The drop tube segment further comprises a valve assembly with a valve member associated with the first end portion, a float, and a linkage device pivotally connected with respect to the valve member. The linkage device is adapted for communication with the float such that the float may facilitate in adjusting the position of the valve member with respect to the first end portion of the conduit in response to a liquid level in a liquid reservoir. The drop tube segment further includes a fastening section located at the second end portion of the conduit for fluid tight fastening with an end portion of another drop tube segment. The fastening section comprises a sealing surface and a threaded portion adapted for threaded engagement with a threaded portion of another drop tube segment.

Abstract: Drop tube segments are provided. Each drop tube segment may be attached to another drop tube segment of a drop tube assembly. The drop tube segments include a wall with a fastener receiving structure that is devoid of any opening extending between inner and outer surfaces of the wall. Methods of making a drop tube assembly are also provided. The methods include the step of inserting a second end portion of a first conduit over a first end portion of a second conduit while edges of an aperture extend radially outwardly away from an outer surface of a first wall of the first conduit.

Abstract: Drop tube inserts and apparatus adapted for use with a riser pipe of a liquid reservoir are provided. Apparatus include a drop tube insert at least partially disposed within an end portion of a drop tube. The drop tube insert includes a wall with inner and outer surfaces wherein the wall of the drop tube insert is devoid of any opening extending between its inner and outer surfaces.

Abstract: The present invention provides 1) an isolated peptide having the amino acid sequence DLMGYIPAV, (SEQ ID NO: 1); 2) an isolated HCV core polypeptide comprising an L→A substitution at amino acid position 139; 3) an isolated HCV core polypeptide having the amino acid sequence of SEQ ID NO: 2; and 4) a fragment of an HCV core polypeptide having fewer amino acids than the entire HCV core polypeptide and comprising the amino acid sequence SEQ ID NO: 1. Also provided are nucleic acids which encode the peptides and polypeptides of this invention, vectors comprising the nucleic acids of this invention and cells comprising the vectors and nucleic acids of this invention. The present invention further provides methods of producing an immune response in a subject and/or treating or preventing HCV infection in a subject, comprising administering to the subject, or to a cell of the subject, any of the compositions of this invention.

Abstract: An automated system and method for interactive scheduling through a web site is disclosed. Vendors' appointment books are accessible through a web site so that customers may schedule appointments at any time and from any location. Customers access the vendor's appointment book by accessing the vendor's web site or selecting the vendor from a list of vendors maintained at a scheduling web site. Several cross-selling features are supported. In addition to scheduling a primary service, customers may schedule add-on and adjacent services that the vendor defines. Vendors who would like to establish a web site that uses special scheduling application software simply complete templates that comprise the content for the web site. A web site is then created for the vendor using service definitions and service provider information provided by the vendor.

Abstract: Peptide constructs comprised of multideterminant T helper peptides from the envelope glycoprotein of HIV previously identified to induce proliferative responses in four different haplotypes of mice and IL-2 responses in 52-73% of HIV positive, flu positive patients (cluster peptides), were co-linearly synthesized with the peptide 18 of the V3 loop of HIV-1 gp 160, corresponding to the principal neutralizing determinant of HIV-IIIB and also shown to contain a dominant CTL epitope. Cognate help for peptide 18 antibody was elicited following a single immunization in all strains of mice which had previously responded to a T cell epitope encompassed by the peptides. In two strains of mice, the level of neutralizing antibody achieved was comparable to levels adequate for protection from homologous viral challenge in chimpanzees. After a single boost, much higher antibody titers for 90% neutralization in the range of 1:1000 to 1:16,000 were achieved.

Abstract: The invention is directed to peptides of the HIV-1 envelope protein presenting multiple immune determinants. The peptide elicits both humoral and cell-mediated immune responses in mice having a variety of MHC types. In other embodiments, the invention is directed to immunogens composed of the peptides and methods for immunization employing them.

Abstract: A container such as a sump having a bottom, at least one wall extending upwardly from the bottom, and a flange connected to the at least one wall and projecting therefrom. The flange preferably has apertures extending partially into the interior portion of the flange from its exterior surface. The flange provides structural rigidity to the container and prevents irregularities from being formed in the walls during manufacture. Preferably, the container is a sump having four lower walls, four upper walls integrally connected to the lower walls by the flange, and four entrance walls integrally connected to the upper walls and defining a mouth for receiving fluids. The flange preferably has an upper surface having upper apertures and a lower surface having lower apertures that are axially aligned with the upper apertures. Pins may utilized during manufacture of the sump by rotational molding to form apertures within the flange and aid in preventing irregularities from being formed.

Abstract: Peptides having high activity in the eliciting of a cytotoxic T lymphocyte response to the HIV-1 envelope glycoprotein gpl60 are described. The activation of 12-15 residue peptides by proteolytic degradation to shorter peptides is shown as are general techniques for characterizing such activation processes.

Abstract: A dispenser sump which includes a deflection surface and a distribution channel for distributing liquids about the interior periphery of the sump to allow insertion of fluid removal apparatus along any wall of the sump. The sump also provides increased structural rigidity to support backfill surrounding the sump and to maintain shape integrity.

Abstract: A unitary sump frame made from a continuous material is disclosed. A substantially planar and continuous flange has an inner perimeter defining an opening in the frame and an outer perimeter. A lip is integrally connected to the flange and extends downwardly from the flange. The lip includes a securing mechanism that is operative to attach a component to the frame. A lug is integrally connected to the lip and extends away from the opening. The lug is operative for anchoring the frame.