Abstract: Provided herein are APP RNAi agents and compositions comprising an APP RNAi agent. Also provided herein are methods of using the APP RNAi agents or compositions comprising an APP RNAi agent in reducing APP expression and/or treating APP associated neurological diseases.

Abstract: The present invention relates to a photochemical process for the manufacturing of a C-terminal ?-amide, which are a class of compounds that represent up to half of all biologically relevant peptide hormones. The invention provides mild, broad in scope, economically efficient process, which is suitable for large scale manufacturing.

Abstract: A microelectromechanical system (MEMS) resonator includes a resonant semiconductor structure, drive electrode, sense electrode and electrically conductive shielding structure. The first drive electrode generates a time-varying electrostatic force that causes the resonant semiconductor structure to resonate mechanically, and the first sense electrode generates a timing signal in response to the mechanical resonance of the resonant semiconductor structure. The electrically conductive shielding structure is disposed between the first drive electrode and the first sense electrode to shield the first sense electrode from electric field lines emanating from the first drive electrode.

Abstract: Disclosed implementations relate to adding “bottleneck” models to machine learning pipelines that already apply domain models to translate and/or transfer representations of high-level semantic concepts between domains. In various implementations, an initial representation in a first domain of a transition from an initial state of an environment to a goal state of the environment may be processed based on a pre-trained first domain encoder to generate a first embedding that semantically represents the transition. The first embedding may be processed based on one or more bottleneck models to generate a second embedding with fewer dimensions than the first embedding. In various implementations, the second embedding may be processed in various ways to train one or more of the bottleneck model(s) based on various different auxiliary loss functions.

Abstract: Air conditioning system for a cabin (10) of an aircraft, comprising: an air bleed device; an air cycle turbine engine (12); at least one main cooling exchanger (16); a water extraction loop (30); and a pipe (26) for distributing water extracted by said extraction loop (30), characterized in that said system further comprises means (40) for heating the water extracted by the water extraction loop so as to be able to spray the water into a ram-air channel (22) which supplies said main exchanger (16).

Abstract: A scientific instrument support apparatus includes memory hardware configured to store instructions and processing hardware configured to execute the instructions.

Abstract: An interface bridge to enable communication between a first integrated circuit die and a second integrated circuit die is disclosed. The two integrated circuit die may be connected via chip-to-chip interconnects. The first integrated circuit die may include programmable logic fabric. The second integrated circuit die may support the first integrated circuit die. The first integrated circuit die and the secondary integrated circuit die may communicate with one another via the chip-to-chip interconnects using an interface bridge. The first and second component integrated circuits may include circuitry to implement the interface bridge, which may provide source-synchronous communication using a data receive clock from the second integrated circuit die to the first integrated circuit die.

Abstract: An apparatus comprises floating-point processing circuitry to perform a floating-point operation with rounding to generate a floating-point result value; and tininess detection circuitry to detect a tininess status indicating whether an outcome of the floating-point operation is tiny. A tiny outcome corresponds to a non-zero number with a magnitude smaller than a minimum non-zero magnitude representable as a normal floating-point number in a floating-point format to be used for the floating-point result value. The tininess detection circuitry comprises hardware circuit logic configured to support both before rounding tininess detection and after rounding tininess detection for detecting the tininess status.

Abstract: The invention provides an apparatus and method to passively lower a stream of individual boards inline with conveyors or other apparatus between a board feeding mechanism, such as an unscrambler machine, and a board handling mechanism such as a stacking machine in the pallet industry. The apparatus includes multiple ramps for lowering the boards.

Abstract: A method is presented for graphically displaying aviation emissions information. The method comprises receiving a global database comprising flight parameters for a plurality of flights over a time period, the flight parameters including at least aviation emissions information for each of the plurality of flights. Aspects of the aviation emissions information are graphically displayed on a display device based on a default model. One or more modeling strategies for reducing aviation emissions over time are presented on the display device via a graphic user interface (GUI). User input indicating input values for one or more strategic parameters of the one or more modeling strategies is received via the GUI. The strategic parameters are applied to the global database to generate modeled emissions information. The graphical display of aspects of the aviation emissions information is adjusted based on the modeled emissions information.

Abstract: A work station including a base includes a work surface pivotally mounted to the base so as to be configured to pivot between a first position and a second position. The work surface is configured to cover a protected member when in a first position and the work surface is configured to uncover the protected member when moved into a second position. The base is configured to support the work surface on a floor surface. A height of the work surface can be adjusted to accommodate the ergonomic needs of different users.

Abstract: A valve spring is provided. The valve spring may include a first turn. The first turn of the valve spring may be disposed at a first angular orientation. The valve spring may further include a second turn. The second turn may be disposed at a second angular orientation. The second angular orientation may be different from the first angular orientation.

Abstract: A method and apparatus wherein a flow of elongated product, such as wooden boards, oriented transverse to the direction of travel; having abutted stacks or piles with numerous layers in a variously misaligned fashion, is received onto the first and uppermost of a series of generally horizontal conveyors arranged in a single vertical array one above the other with each subsequent level operating in a direction opposite of the level above it.

Abstract: Systems and methods are provided for dynamically modeling and depicting overall emissions of the aviation industry and changes thereto when taking into account, for example, traffic growth and introduction of sustainability strategies, such as new and/or improved technologies, an increase in operational efficiency, and carbon offsets. Using the dynamic tool described herein, users can define scenarios on how to reduce emissions through the introduction of different sustainability strategies, both statically and over time, analyze the impact of those strategies on emissions, and understand the dependencies between select strategies.

Abstract: In one embodiment, an offload platform is an compute platform, adjunct to a router or other packet switching device, that performs packet processing operations including determining an egress forwarding value corresponding to the next-hop node of the packet switching device to which to send an offload-platform processed packet. The offload platform downloads forwarding information from the router, and augments it, such as, but not limited to, representing interfaces of the router as identifiable virtual interface(s) on the offload platform, and including each of one or more next-hop nodes of the router represented as an identifiable virtual adjacency and identifiable tunnel (e.g., identified by the egress forwarding value). In one embodiment, the egress forwarding value is an Multiprotocol Label Switching (MPLS) label or Segment Routing Identifier. The router identifies packets of certain packet flows to send to the adjunct offload platform, rather than processing per its routing information base.

Abstract: A work station including a base includes a work surface pivotally mounted to the base so as to be configured to pivot between a first position and a second position. The work surface is configured to cover a protected member when in a first position and the work surface is configured to uncover the protected member when moved into a second position. The base is configured to support the work surface on a floor surface. A height of the work surface can be adjusted to accommodate the ergonomic needs of different users.

Abstract: In one embodiment, an offload platform is an compute platform, adjunct to a router or other packet switching device, that performs packet processing operations including determining an egress forwarding value corresponding to the next-hop node of the packet switching device to which to send an offload-platform processed packet. The offload platform downloads forwarding information from the router, and augments it, such as, but not limited to, representing interfaces of the router as identifiable virtual interface(s) on the offload platform, and including each of one or more next-hop nodes of the router represented as an identifiable virtual adjacency and identifiable tunnel (e.g., identified by the egress forwarding value). In one embodiment, the egress forwarding value is an Multiprotocol Label Switching (MPLS) label or Segment Routing Identifier. The router identifies packets of certain packet flows to send to the adjunct offload platform, rather than processing per its routing information base.

Abstract: A method and apparatus to improve the performance of acoustic beamformers composed of accelerometer-based Acoustic Vector Sensors (AVS) is disclosed. Most AVS are composed of a set of spatially separated microphones, for which tradeoffs exist based on the array size and number of elements, geometry, frequency bandwidth, and system cost. Accelerometer-based AVS are composed of a one or more triaxial accelerometers, each paired with a collocated MEMS microphone. This results in much smaller array apertures for equivalent performance, and a significant reduction in unwanted sidelobes.

Abstract: A microelectromechanical system (MEMS) resonator includes a resonant semiconductor structure, drive electrode, sense electrode and electrically conductive shielding structure. The first drive electrode generates a time-varying electrostatic force that causes the resonant semiconductor structure to resonate mechanically, and the first sense electrode generates a timing signal in response to the mechanical resonance of the resonant semiconductor structure. The electrically conductive shielding structure is disposed between the first drive electrode and the first sense electrode to shield the first sense electrode from electric field lines emanating from the first drive electrode.

Abstract: An airborne acoustic vector sensor for simultaneously measuring triaxial particle acceleration in three dimensions and pressure includes a triaxial MEMS accelerometer sensitive to an Earth gravitational field. The airborne acoustic vector sensor includes one or multiple MEMS microphones sensitive to sound pressure and overlapping the accelerometer in frequency. The airborne acoustic vector sensor includes a solid body having a density approximating a density of air. The accelerometer is mounted in or upon the solid body. The airborne acoustic vector sensor includes a suspension system supporting the accelerometer and solid body within a framework.