Abstract: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.

Abstract: A system for secure information storage and delivery includes a vault repository that includes a secure vault associated with a user, wherein the secure vault is configured to receive at least one data entry. A mobile vault server coupled to the vault repository creates a mobile vault on a mobile device based on the secure vault and is capable of authenticating the mobile device based on user authentication information. The mobile vault server includes a mobile device handler that communicates with the mobile device. A synchronization utility determines whether the at least one data entry on the secure vault is transferable to or storable on the mobile vault. and transfers the data entry from the secure vault to a corresponding data entry on the mobile vault if the at least one data entry on the secure vault is determined to be transferable to or storable on the mobile vault.

Abstract: The present disclosure relates to using windowing to reduce the bandwidth of an amplitude modulation (AM) power supply input signal (PSIS), which is fed to an AM power supply to provide envelope power to an RF power amplifier stage via an AM power supply output signal. By reducing the bandwidth, noise levels from the AM power supply may be reduced. However, although the bandwidth of the AM PSIS is reduced, the AM power supply output signal may track the AM of the RF power amplifier stage closely enough to meet linearity requirements and to provide high efficiency. The windowing may be based on dividing a stream of AM input samples into a stream of input windows, from which a stream of output windows is created to provide a stream of windowed AM input samples that are used to provide a windowed AM PSIS to the AM power supply.

Abstract: A vehicle is provided with a chassis having a footprint, a load carrying structure, and a support assembly coupling the chassis and the structure. The support assembly is adapted to move the structure relative to the chassis between a stowed position and a deployed position outboard of the footprint of the chassis. A plurality of wheels is configured to roll on the support surface and a plurality of axles coupling the wheels to the chassis are provided. Each axle includes at least one spindle supporting an individual wheel for rotation on a spindle axis. A steering system is adapted to position the wheels between driving and rotation arrangements with respect to the chassis such that in the rotating arrangement each of the plurality of wheels rotate relative to the chassis whereby the chassis, the platform and the support assembly may rotate in unison about the steer axis.

Abstract: A system for secure information storage and delivery includes a vault repository that includes a secure vault associated with a user, wherein the secure vault is associated with a service level including at least one of a data type or a data size limit associated with the secure vault, the secure vault being adapted to receive and at least one data entry and securely store the at least one data entry if the at least one of a size or a type of the at least one data entry is consistent with the service level. A mobile vault server coupled to the vault repository creates a mobile vault on a mobile device based on the secure vault and is capable of authenticating the mobile device based on user authentication information. The mobile vault server includes a mobile device handler that communicates with the mobile device.

Abstract: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

Abstract: The present invention relates to image rejection calibration in a radio frequency (RF) receiver. In one embodiment, the receiver includes a receiver front-end and an image rejection calibration system. The image rejection calibration system provides a first test signal to an RF input of the receiver front-end, and obtains first measurements of a quadrature output signal output from the receiver front-end while the first test signal is applied to the RF input. The image rejection calibration system then applies a second test signal to the RF input of the receiver front-end that is approximately 90 degrees out-of-phase with the first test signal, and obtains second measurements of the quadrature output signal while the second test signal is applied to the RF input. Based on the first and second measurements, the image rejection calibration system determines an amplitude error and a phase error of the receiver front-end.

Abstract: A method of treating exposure to organophosphate agents and preventing morbidity due to such exposure through the administration of a pyrazolopyrimidine compound such as ocinaplon, zaleplon, indiplon, or divaplon.

Abstract: A vehicle controlled via a joystick has a turn request mode and a return to center request. While the operator is requesting a turn, steered wheels are turned at a predetermined rate, steering angle continuing to change while the turn request is being applied. When the operator ceases requesting a turn, the return to center mode is invoked: a direction of a virtual wheel of the vehicle is determined and such direction is maintained. A vehicle angular velocity is computed based on vehicle velocity and a virtual steering angle, which is the angle between the direction the virtual wheel is pointing and the longitudinal axis of the vehicle. To maintain the direction of the virtual wheel during a return to center, the virtual wheel is turned at an angular velocity equal in magnitude to the angular velocity of the vehicle and in a direction to return to center.

Abstract: Methods of improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are disclosed, as well as compounds and pharmaceutical compositions useful therein.

Abstract: In one embodiment of the invention, a master tool is disclosed including a top plate, a plurality of buttons, and a releasable locking mechanism. The top plate has an array of openings and a top side with a background patterned surface. The plurality of buttons are in the array of openings and configured to be repositioned to selectively orient their orientable patterned surface into a different orientation with respect to the background patterned surface. The releasable locking mechanism releasably locks the position of the plurality of buttons within the array of openings to hold the selected orientation of each orientable patterned surface with respect to the background patterned surface to provide a top surface pattern. The top surface pattern of the master tooling may be transferred to form a surface pattern into retro-reflective sheeting during its manufacture.

Abstract: In one embodiment of the invention, retro-reflective sheeting is disclosed. The retro-reflective sheeting comprises a flexible optical material film or substrate having a geometric optical surface opposite a base surface. The geometric optical surface includes a background pattern region of corner cubes arranged at a first orientation with respect to an edge of the retro-reflective sheeting; and an array of circular corner cube regions periodically interrupting the background pattern region of corner cubes. Each of the circular corner cube regions has a second orientation with respect to the edge of the retro-reflective sheeting. The array of the plurality of circular corner cube regions reflects incident light differently than the background pattern region of corner cubes.

Abstract: A method and a system for calibrating an X-ray photoelectron spectroscopy (XPS) measurement are described. The method includes using an X-ray beam to generate an XPS signal from a sample and normalizing the XPS signal with a measured or estimated flux of the X-ray beam. The system includes an X-ray source for generating an X-ray beam and a sample holder for positioning a sample in a pathway of the X-ray beam. A detector is included for collecting an XPS signal generated by bombarding the sample with the X-ray beam. Also included are a flux detector for determining a measured or estimated flux of the X-ray beam and a computing system for normalizing the XPS signal with the measured or estimated flux of the X-ray beam.

Abstract: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the tubulo-vesicular structures of polarized cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.

Abstract: A method to determine a distribution profile of an element in a film. The method comprises exciting an electron energy of an element deposited in a first film, obtaining a first spectrum associating with the electron energy, and removing a background spectrum from the first spectrum. Removing the background value generates a processed spectrum. The method further includes matching the processed spectrum to a simulated spectrum with a known simulated distribution profile for the element in a film comparable to the first film. A distribution profile is obtained for the element in the first film based on the matching of the processed spectrum to a simulated spectrum selected from the set of simulated spectra.

Abstract: A system and method for communicating over a single virtual channel. The method includes reserving a first group of credits of a credit pool for a first traffic class and a second group of credits of the credit pool for a second traffic class. In addition, a first and second respective groups of tags are reserved from a tag pool for the first and second traffic class. A packet may then be selected from a first buffer for transmission over the virtual channel. The packet may include a traffic indicator of the first traffic class operable to allow the packet to pass a packet of the second traffic class from a second buffer. The method further includes sending the packet over the virtual channel and adjusting the first group of credits and the first group of tags based on having sent a packet of the first traffic class.

Abstract: A disc brake rotor having a central hat portion for coupling a rotor to a vehicle wheel for rotation about a central axis, an inboard brakeplate for receiving a first friction surface and an outboard brakeplate for receiving a second friction surface. A plurality of L-shaped rib members extends from the hat for coupling the inboard brakeplate to the hat and a second plurality of L-shaped members radially extend from the hat for coupling the outboard brakeplate to the hat. First plurality of ribs is longer than the second plurality of ribs. The second set L-shaped members is located intermediate of the edges of the inboard and outboard pluralities to enhance the heat transfer of the braking operation.

Abstract: Embodiments of the present invention include amplitude-modulated or polar-modulated radio frequency (RF) power amplifier circuitry, in which an envelope power supply input to an RF power amplifier is powered by a pre-distorted amplitude modulation (AM) power supply. The pre-distorted AM power supply receives an AM signal, which is then pre-distorted and amplified to provide an AM power supply signal to the RF power amplifier. The pre-distortion of the AM signal is used to improve the linearity, the efficiency, or both, of the RF power amplifier. The pre-distortion provides a feed-forward system, which may allow use of a reduced bandwidth pre-distorted AM signal to an AM power supply and a reduced bandwidth AM power supply, which may increase efficiency.

Abstract: A method to determine a distribution profile of an element in a film. The method comprises exciting an electron energy of an element deposited in a first film, obtaining a first spectrum associating with the electron energy, and removing a background spectrum from the first spectrum. Removing the background value generates a processed spectrum. The method further includes matching the processed spectrum to a simulated spectrum with a known simulated distribution profile for the element in a film comparable to the first film. A distribution profile is obtained for the element in the first film based on the matching of the processed spectrum to a simulated spectrum selected from the set of simulated spectra.