Abstract: The present invention is directed to Benzomorphan Analog compounds of the Formula (I), Formula (IA), Formula (IB), Formula (IC), or Formula (ID) as shown below, wherein R1, R2a, R2b, R3, R4, Z, and G are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.

Abstract: In systems and methods of managing wireless communication link resources, a static overhead load, a data traffic load, and a signaling load are determined of a wireless communication link between an access node and at least one wireless device. A wireless communication link load is calculated based on the static overhead load, the data traffic load, and the signaling load, and a load control process is performed when the wireless communication link load meets a load criteria.

Abstract: The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.

Abstract: A wireless network access device comprising a radio interface with a serial communication line, a switch, and M serial connections to M connectors for connecting up to M corresponding detachable radio modules. The radio interface forms up to M individually addressable radio communications paths. Each radio module includes a radio configured to communicate with client devices in a coverage area and a radio processor configured to manage at least one radio receiving buffer. The radio receiving buffers store receiver buffer identifiers to corresponding received data space. A processor manages communication between the client devices that communicate with the radio modules and a data network via the radio interface and a network interface when N?M radio modules are connected to the radio interface. An assist engine is connected in the serial connection between the processor and the switch to manage allocation of receive buffer identifiers to the radio modules.

Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.

Abstract: The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.

Abstract: A wireless network access device comprising a radio interface with a serial communication line, a switch, and M serial connections to M connectors for connecting up to M corresponding detachable radio modules. The radio interface forms up to M individually addressable radio communications paths. Each radio module includes a radio configured to communicate with client devices in a coverage area and a radio processor configured to manage at least one radio receiving buffer. The radio receiving buffers store receiver buffer identifiers to corresponding received data space. A processor manages communication between the client devices that communicate with the radio modules and a data network via the radio interface and a network interface when N <M radio modules are connected to the radio interface. An assist engine is connected in the serial connection between the processor and the switch to manage allocation of receive buffer identifiers to the radio modules.

Abstract: A valveless, pulsatile, non-contact, positive displacement, finger-pump for pumping one or more fluids is disclosed. The pump can include one or more channels for holding one or more lengths of flexible tubing. The channels can include an adjustment mechanism and/or a resilient backing plate to reduce over compression of the tubing. The pump can utilize a plurality of profiled, pivoting fingers to sequentially occlude a length of tubing causing a pumping action. The fingers can be moved from the first position to the second position by a motor driven camshaft. Cam lobes disposed on the camshaft can be a modified eccentric design to improve tube occlusion and pump efficiency. At least one cam lobe can completely occlude the tubing at all times during operation to prevent backflow. The fingers can alternatively be moved from the first position to the second position by a variety of linear actuators.

Abstract: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

Abstract: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

Abstract: The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.

Abstract: The disclosure of the present application provides compositions and methods for treating a blood disorder. In at least one embodiment of a method for treating a patient with a plasma protein deficiency disorder, the method comprises the steps of administering a cell-based composition to a patient with a plasma protein deficiency disorder to treat the plasma protein deficiency disorder, where the cell-based composition comprises a mammalian adipose stromal cell that is capable of effectuating the production of a plasma protein within the patient.

Abstract: N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

Abstract: A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.

Abstract: The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.

Abstract: The present invention is a peptide compound which stimulates the formation of hard tissues such as bone and cartilage. The invention is also related to a method to treat a defect in hard tissues such as bone and cartilage using the peptide. The method of the present invention may be used to treat or prevent the defects in bones and cartilages which are caused by rheumatoid arthritis or osteoarthritis which involves the regeneration of new bone or cartilage in or around the defects.

Abstract: Digitally distributing media content using a distribution backbone system, including: receiving a request for media content from a client, the request including a client profile; performing inventory and analysis of source assets by iteratively progressing through the client profile to create output; performing a capability mapping in which a series of rules that allow the source assets to be mapped to the client profile; and planning a manufacturing process, which determines work items and execution steps from capabilities mapped in response to the request for media content from the client.

Abstract: The present invention provides a method for making an ophthalmic device. In particular, the present invention provides a method for production of a contact lens by means of stereolithography. A preferred stereolithography technique is based on polymerization and solidification of a contact lens forming liquid material by actinic irradiation one layer at a time. In addition, the present invention provides systems and methods for making a contact lens for a specific patient based on the prescription.

Abstract: As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

Abstract: The invention provides systems, compositions, kits and methods for automated processing of biological samples and analysis using a flow cytometer.