Abstract: The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.

Abstract: Provided herein are antibodies that bind signal regulatory protein SIRP? and methods of making and using such antibodies. In some embodiments, the antibodies comprise an Fc, and are useful for preferential depletion of certain SIRP? expressing cells. In some embodiments, the antibodies provided herein are useful for treating a disease or condition associated with the dysregulation of cells (e.g. overactivation or aberrant proliferation of T-cells).

Abstract: Provided here are antibodies that bind Protein S, and methods of making and using such antibodies. In some embodiments, the Protein S antibodies provided herein are useful for treating a bleeding disorder or platelet disorder, or a condition characterized by reduced or impaired blood coagulation and/or clotting.

Abstract: Described herein are systems, devices, and methods for removing material from patient vasculature. In some embodiments, an aspiration device may include a sheath and a catheter slidably disposed within the sheath and defining a lumen. The catheter may include a distal end portion and an elongate portion, the distal end portion being disposable adjacent to a clot, the elongate portion being couplable to a vacuum source that is configured to apply a negative pressure to the lumen to draw the clot into the distal end portion. The distal end portion may include a plurality of sections, each of the plurality of sections having a different cut pattern.

Abstract: The present disclosure provides devices for removal of hair, such as by cutting of the hair. The devices can include a cutting assembly or blade assembly that can include at least one moving blade and at least one stationary blade. The blades may be provided within a blade assembly housing. A stationary blade can include an externally facing edge with a curved arrangement that improves passage of the blade assembly across skin for hair removal with reduced chance for nicking of skin or other discomfort. The blade assembly may be combined with a handle. The blade assembly may be attached to the handle so that the blade assembly is arrange for continuous rotation to a desired angle to improve case of use thereof.

Abstract: The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed.

Abstract: A tele-presence system that includes a cart. The cart includes a robot face that has a robot monitor, a robot camera, a robot speaker, a robot microphone, and an overhead camera. The system also includes a remote station that is coupled to the robot face and the overhead camera. The remote station includes a station monitor, a station camera, a station speaker and a station microphone. The remote station can display video images captured by the robot camera and/or overhead camera. By way of example, the cart can be used in an operating room, wherein the overhead camera can be placed in a sterile field and the robot face can be used in a non-sterile field. The user at the remote station can conduct a teleconference through the robot face and also obtain a view of a medical procedure through the overhead camera.

Abstract: Described herein are systems, devices, and methods for aspiration and mechanical thrombectomy. In some embodiments, a thrombectomy device for removing a thrombus from a vessel can include a handle assembly, a vacuum source, an aspiration catheter with an expandable distal portion, and a flexible shaft configured to rotate within the aspiration catheter.

Abstract: Quadrantanopial occlusive lenses and method of use includes the steps of performing a vision zone assessment test to identify a field area of a patient's field of view having a selected characteristic, based on the identified field area, providing an appliance having a non-transparent optical characteristic associated with the field area, the patient wearing the appliance, and while the patient is wearing the appliance, the patient performing a selected activity associated with the neurological performance. The neurological performance may be associated with the quality of performance of the selected activity. The selected activity may be a physical activity. The step of performing a vision zone assessment test may include moving a visual target about the patient's field of view. The step of performing a vision zone assessment test may include observing the patient's eye movements in response to a moving visual stimulus.

Abstract: Embodiments of the present disclosure generally relate to methods for analyzing outcomes of illnesses, such as COVID-19, on living organisms. More particularly, embodiments of the present disclosure relate to methods for identifying risk of illness based on genetic markers and other available data, predicting results of mass exposure to an Illness based on a populations genomes and other available data, and providing indicators and methods of visualization for probability of illness in any living organism.

Abstract: Described herein are systems, devices, and methods for removing material from patient vasculature. In some embodiments, an aspiration device may include a sheath and a catheter slidably disposed within the sheath and defining a lumen. The catheter may include a distal end portion and an elongate portion, the distal end portion being disposable adjacent to a clot, the elongate portion being couplable to a vacuum source that is configured to apply a negative pressure to the lumen to draw the clot into the distal end portion. The distal end portion may include a plurality of sections, each of the plurality of sections having a different cut pattern.

Abstract: Described herein are systems, devices, and methods for aspiration and mechanical thrombectomy. In some embodiments, a thrombectomy device for removing a thrombus from a vessel can include a handle assembly, a vacuum source, an aspiration catheter with an expandable distal portion, and a flexible shaft configured to rotate within the aspiration catheter.

Abstract: Provided herein are antibodies that bind signal regulatory protein gamma (SIRP?), as well as SIRP? and/or SIRP?1, and methods of using such antibodies (referred to as SIRP antibodies). In some embodiments, the SIRP antibodies are human monoclonal antibodies that bind human SIRP? as well as SIRP? and/or SIRP?1. In some embodiments, the SIRP antibodies provided herein are useful for treating a disease or condition associated with overactivation and/or hyperproliferation of lymphocytes, myeloid cells, or a combination thereof, or a disease or condition associated with SIRP?, SIRP?1 and/or SIRP? activity.

Abstract: Provided here are antibodies that bind Protein S, and methods of making and using such antibodies. In some embodiments, the Protein S antibodies provided herein are useful for treating a bleeding disorder or platelet disorder, or a condition characterized by reduced or impaired blood coagulation and/or clotting.

Abstract: A method includes obtaining a rule that is associated with a segment of a map, determining a state for use in evaluation of the rule, evaluating the rule using the state, identifying an action to be performed based on a result of evaluating the rule using the state, and utilizing the action to be performed as an input to an automated control system of a vehicle.

Abstract: Provided herein are antibodies that bind signal regulatory protein gamma (SIRPy), as well as SIRP? and/or SIRP?1, and methods of using such antibodies (referred to as SIRP antibodies). In some embodiments, the SIRP antibodies are human monoclonal antibodies that bind human SIRPy as well as SIRP? and/or SIRP?1. In some embodiments, the SIRP antibodies provided herein are useful for treating a disease or condition associated with overactivation and/or hyperproliferation of lymphocytes, myeloid cells, or a combination thereof, or a disease or condition associated with SIRP?, SIRP?1 and/or SIRPy activity.

Abstract: A kit of eyewear that comprises a plurality of eyewear elements, each having a frame and a lens associated with each eye. Each of the eyewear elements have an occluded portion of at least one lens; at least some of the eyewear elements having different occlusion areas on the left and right lenses; and the eyewear elements having different occlusions patterns from each other.

Abstract: Provided herein are antibodies that bind signal regulatory protein SIRPa, SIRPß1, or a combination of SIRPa and SIRP?1, and methods of using such antibodies. In some embodiments, the antibodies are human monoclonal antibodies that bind human SIRPa and/or SIRP?1. In some embodiments, the antibodies provided herein are useful for treating a disease or condition associated with overactivation and/or hyperproliferation of myeloid cells, or a disease or condition associated with SIRPa and/or SIRP?1 activity.

Abstract: Provided here are antibodies that bind Protein S, and methods of making and using such antibodies. In some embodiments, the Protein S antibodies provided herein are useful for treating a bleeding disorder or platelet disorder, or a condition characterized by reduced or impaired blood coagulation and/or clotting, e.g. by depleting the circulating levels of TFPI, by disrupting a Protein S-TFPI complex, and/or by preventing the formation of a Protein S-TFPI complex.

Abstract: Provided here are antibodies that bind Protein S, and methods of making and using such antibodies. In some embodiments, the Protein S antibodies provided herein are useful for treating a bleeding disorder or platelet disorder, or a condition characterized by reduced or impaired blood coagulation and/or clotting.