Abstract: A method for obtaining 225AC from 225Ra having the steps of assembling a column having an inorganic stationary phase; priming the column to immobilize 226Ra 225Ra and natural decay products therefrom; immobilizing the 226Ra, 225Ra, 224Ra, and natural decay products therefrom onto a stationary phase within the column; and eluting the column containing the 225Ra with an aqueous sulfate solution to obtain a milking effluent that contains 225AC. Also provided is a method for obtaining pure 225AC from its isotope parents, the method comprising assembling a column having a stationary phase comprising an inorganic material; priming the column with the isotope parents to immobilize 225Ac, and natural decay products of 225AC; immobilizing the 225Ac, and natural decay products therefrom onto the stationary phase within the column 226Ra, 225Ra, 224Ra; and eluting the column containing the 225AC to obtain an effluent that contains the isotope parents.

Abstract: A remotely controllable sublimation apparatus that includes a crucible block adapted to retain a crucible containing a solid mixture comprising one or more radionuclides, a first heating block comprising one or more first heating elements configured to selectively generate heat having a first temperature sufficient to at least partially sublime the solid mixture, and a collection vessel coupled to the first heating block. The crucible block is movable, relative to the first heating block, between an open position and a closed positon. When the crucible block is in the closed position, the one or more first heating elements are configured to heat the crucible block to the first temperature, thereby heating the solid mixture and producing a vapor that is collected by the collection vessel and leaving a solid residue in the crucible that substantially consists only of the one or more radionuclides.

Abstract: A converter for generating photons from an electron beam is provided. The converter may include a plurality of converter plates (i) positioned perpendicular to an axis and (ii) arranged sequentially in a direction along the axis from a first converter plate of the plurality of converter plates to a last converter plate of the plurality of converter plates. The first converter plate may be configured to receive an electron beam traveling in the direction along the axis. Further, the first converter plate may have a thickness smaller than a thickness of the last converter plate, wherein a thickness of a particular converter plate is measured along the axis.

Abstract: The invention provides a system for containing irradiated particles, the system having a housing having a closed upstream end and an open downstream end; an axially disposed tunnel extending from the downstream end to the upstream end, wherein longitudinally extending regions of the tunnel define a plurality of threaded surfaces; a sample cup positioned within the tunnel and proximal to the closed upstream end; threaded plugs matingly received by the threaded surfaces so as to provide at least one seal between the sample cup and the atmosphere external of the housing; and a plurality of deformable substrates disposed between the plugs.

Abstract: The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.

Abstract: The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.

Abstract: The invention provides an automated method for isolating a targeted isotope, the method having the steps of supplying a dissolved uranium targets into a first reaction environment; precipitating non-targeted isotope within the first reaction environment transferring liquid phase targeted isotope to a second reaction environment; precipitating the liquid phase targeted isotope in the second reaction environment; dissolving the precipitated targeted isotope; transferring the dissolved targeted isotope to a third reaction environment; and precipitating non-targeted isotope (i.e., iodine), such that the targeted isotope remains in the solution. Also provided is an automated system for isolating isotopes, the system having a plurality of reaction environments adapted to pneumatically receive and disgorge reactants and products via remotely actuated valves positioned between each of the reaction environments.

Abstract: A method for obtaining 225AC from 225Ra having the steps of assembling a column having an inorganic stationary phase; priming the column to immobilize 226Ra 225Ra and natural decay products therefrom; immobilizing the 226Ra, 225Ra, 224Ra, and natural decay products therefrom onto a stationary phase within the column; and eluting the column containing the 225Ra with an aqueous sulfate solution to obtain a milking effluent that contains 225AC. Also provided is a method for obtaining pure 225AC from its isotope parents, the method comprising assembling a column having a stationary phase comprising an inorganic material; priming the column with the isotope parents to immobilize 225Ac, and natural decay products of 225AC; immobilizing the 225Ac, and natural decay products therefrom onto the stationary phase within the column 226Ra, 225Ra, 224Ra; and eluting the column containing the 225AC to obtain an effluent that contains the isotope parents.

Abstract: A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.

Abstract: The invention provides a continuous method for extracting transition metal, the method comprising: supplying a spent generator liquor comprising transition metal in highly alkaline solution; mixing the liquor with acid thereby generating a solution, wherein the transition metal resides within the solution; combining the solution with an organic liquid comprising tributyl phosphate or other neutral extractant to extract the transition metal within the organic liquid; washing the extracted transition metal in the organic liquid with acid so as to remove non-transition-metal salts from the organic liquid phase; and stripping the washed transition metal loadedorganic liquid phase with hydroxide, water or complexing agent to remove the transition metal from the organic phase.

Abstract: The invention provides a method for generating medical isotopes, the method comprising contacting a primary radiation beam with a converter for a time sufficient to produce a secondary beam of gamma particles, and contacting the beam of gamma particles to a target, where the cross section dimension of the beam of gamma particles is similar to the cross section dimension of the target. Both the converter and target are small in diameter and very closely spaced. Also provided is a system for producing medical isotopes, the device comprising a housing having a first upstream end and a second downstream end, a radiotransparent channel (collimator) with a first upstream end and a downstream end, wherein the upstream end is adapted to receive a radiation beam, a target positioned downstream of the downstream end of the channel and coaxially aligned with the channel, wherein the target has a cross section that is similar to the cross section of the channel.

Abstract: The invention provides a system for containing irradiated particles, the system having a housing having a closed upstream end and an open downstream end; an axially disposed tunnel extending from the downstream end to the upstream end, wherein longitudinally extending regions of the tunnel define a plurality of threaded surfaces; a sample cup positioned within the tunnel and proximal to the closed upstream end; threaded plugs matingly received by the threaded surfaces so as to provide at least one seal between the sample cup and the atmosphere external of the housing; and a plurality of deformable substrates disposed between the plugs.

Abstract: The invention provides a continuous method for extracting transition metal, the method comprising: supplying a spent generator liquor comprising transition metal in highly alkaline solution; mixing the liquor with acid thereby generating a solution, wherein the transition metal resides within the solution; combining the solution with an organic liquid comprising tributyl phosphate or other neutral extractant to extract the transition metal within the organic liquid; washing the extracted transition metal in the organic liquid with acid so as to remove non-transition-metal salts from the organic liquid phase; and stripping the washed transition metal loadedorganic liquid phase with hydroxide, water or complexing agent to remove the transition metal from the organic phase.