Patents by Inventor David A. Saperstein

David A. Saperstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20190133986
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Retinoid replacements and opsin agonists and methods for the use thereof
    Patent number: 10238610
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: March 26, 2019
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • METHODS OF TREATING OR PREVENTING A PROTEOPATHY
    Publication number: 20180099974
    Abstract: Methods for the treatment or prevention of a proteopathy are described herein.
    Type: Application
    Filed: December 8, 2017
    Publication date: April 12, 2018
    Inventor: David Saperstein
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20180098955
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: December 12, 2017
    Publication date: April 12, 2018
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Retinoid replacements and opsin agonists and methods for the use thereof
    Patent number: 9907761
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: March 6, 2018
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20180008556
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 11, 2018
    Applicant: University Of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 9855239
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: January 2, 2018
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20160331713
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: July 26, 2016
    Publication date: November 17, 2016
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 9408821
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 9, 2016
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 9233091
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: January 12, 2016
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Retinoid replacements and opsin agonists and methods for the use thereof
    Patent number: 8962691
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 24, 2015
    Assignee: University of Washington
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20130072568
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof Palczewski, David A. Saperstein
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20130072558
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20130072557
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20130072561
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxyiates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: University of Washington
    Inventors: Tadao Maeda, David SAPERSTEIN, Krzysztof PALCZEWSKI
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20130072569
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof PALCZEWSKI, David A. SAPERSTEIN
  • RETINOID REPLACEMENTS AND OPSIN AGONISTS AND METHODS FOR THE USE THEREOF
    Publication number: 20120322891
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: March 14, 2012
    Publication date: December 20, 2012
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: KRZYSZTOF PALCZEWSKI, DAVID A. SAPERSTEIN
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 8324270
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: December 4, 2012
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • METHODS FOR THE TREATMENT AND PREVENTION OF AGE-RELATED RETINAL DYSFUNCTION
    Publication number: 20100035986
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Application
    Filed: February 10, 2009
    Publication date: February 11, 2010
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Retinoid replacements and opsin agonists and methods for the use thereof
    Publication number: 20060281821
    Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: March 15, 2004
    Publication date: December 14, 2006
    Inventors: Krzysztof Palczewski, David Saperstein