Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: A composition of copper phthalocyanines containing, on average, from 0.1 to 3 methyl groups per phthalocyanine nucleus. The composition is suitable for the coloration of paints and plastics materials.

Abstract: A dispersant of general Formula I T—(A)n(B)p—Z   (1) wherein T is hydrogen or a polymerisation terminating group; Z is an acidic or basic group or a moiety containing either an acidic or basic group; A and B are each, independently, oxyalkylene carbonyl groups derivable from &dgr;-valerolactone, &egr;-caprolactone or alkyl substituted &egr;-caprolactone provided that both are not &egr;-caprolactone or &dgr;-valerolactone; n and p are integers; and n+p is from 2 to 100; including salts thereof. Specific examples of dispersants are the reaction product of lauric acid, &dgr;-caprolactone, 7-methyl-&egr;-caprolactone with PEI, the reaction product of lauric acid, &egr;-caprolactone, &dgr;-valerolactone with PEI and the phosphate of the reaction product of dodecanol, &egr;-caprolactone and &dgr;-valerolactone.

Abstract: A dispersant for aqueous mill-bases obtainable by reacting a polyethylene glycol with a molar excess of a hydroxycarboxylic acid containing from 4 to 17 carbon atoms or lactone thereof and/or with a C3-4-alkylene oxide to form a polymeric diol and phosphating the diol. The preferred hydroxycarboxylic acid or lactone is &egr;-caprolactone.

Abstract: A rheology modifier for solvent-based coatings which is a polyacrylic acid or a poly(C.sub.1-4)-alkyl acrylic acid wherein at least 30% of the --COOH groups are converted to ester and/or amide groups. Preferred compounds are esters of polyacrylic acid where about 50% of the --COOH groups are esterified with a C.sub.4-12 -alcohol.

Abstract: A composition of copper phthalocyanines containing, on average, from 0.1 to 3 methyl groups per phthalocyanine nucleus. The composition is suitable for the coloration of paints and plastics materials.

Abstract: An ink jet printer ink of the kind comprising a dispersion of a pigment in a non-aqueous diluent wherein the diluent is a single phase liquid comprising a major amount of aliphatic hydrocarbon and a minor amount of a polar component, comprising oleyl alcohol alone or in combination with a least one other polar liquid such as an ether or an ester.

Abstract: A dispersant for aqueous mill-bases obtainable by reacting a polyethylene glycol with a molar excess of a hydroxycarboxylic acid containing from 4 to 17 carbon atoms or lactone thereof and/or with a C.sub.3-4 -alkylene oxide to form a polymeric diol and phosphating the diol. The preferred hydroxycarboxylic acid or lactone is .epsilon.-caprolactone.

Abstract: A method of preparing a non-aqueous dispersion of CuPc which comprises milling crude CuPc in a high boiling liquid at a temperature from 50.degree. to 150.degree. C. in the presence of a polyester amine or polyesterammonium salt and a CuPc fluidising agent. Preferred polyesterammonium salt is obtainable by reacting polyhydroxystearic acid with 3-dimethylaminopropylamine quaternised with dimethylsulphate.

Abstract: A dispersant comprising a polyethyleneimine residue carrying polyester chains derived from a caprolactone and at least one other specified lactone or hydroxycarboxylic acid.

Abstract: Benzamides of the formula (I): ##STR1## in which Ar is optionally substituted aryl; X is O, S or NH and R is optionally substituted alkyl or alkenyl when X is O or S, or is optionally substituted alkanoyl when X is NH, are prepared by(a) reacting a compound of the formula (II):ArCONHCH.sub.2 CN (II)with a brominating agent in a solvent which is substantially chemically inert to the reactants and in which compound (II) is soluble, to form a compound of the formula (III): ##STR2## and (b) reacting the compound (III) with a compound RXH.Preferably, bromination is carried out rapidly in dried ethyl acetate.The process avoids hydration of the CN group of the compound (III) to a carbamoyl group obviating a subsequent dehydration step later.The intermediate compound (III) is novel.The substituted benzamides are useful as herbicides and fungicides.

Abstract: Substituted naphthalenyloxy- or naphthalenylthiooxyamides of trans-1,2-diaminocyclohexanes possess selective kappa opioid receptor site binding activity and are thus useful as analgesic or diuretic agents. Methods of preparing the compounds, pharmaceutical compositions, and a method for their use as analgesic agents are also disclosed.

Abstract: Benzamides of the formula (I): ##STR1## in which Ar is optionally substituted aryl; X is O, S or NH and R is optionally substituted alkyl or alkenyl when X is O or S, or is optionally substituted alkenoyl when X is NH, are prepared by(a) reacting a compound of the formula (II):ArCONHCH.sub.2 CN (II)with a brominating agent in a solvent which is substantially chemically inert to the reactants and in which compound (II) is soluble, to form a compound of the formula (III): ##STR2## and (b) reacting the compound (III) with a compound RXH.Preferably, bromination is carried out rapidly in dried ethyl acetate.The process avoids hydration of the CN group of the compound (III) to a carbamoyl group obviating a subsequent dehydration step later.The intermediate compound (III) is novel.The substituted benzamides are useful as herbicides and fungicides.

Abstract: The invention provides a computer store having successively addressed storage locations for individual words grouped together to form so-called clotheslines. Data can be written into and read out from either end of a clothesline. A clothesline thus combines the properties of a stack and a silo and can be considered as either a double-ended stack or as a reversible silo.

Abstract: Process for the preparation of esters of m-phenoxybenzyl alcohol and its .alpha.-cyano and .alpha.-ethinyl derivatives with carboxylic acids containing at least 6 carbon atoms by heating together a methyl or ethyl ester of the carboxylic acid, an ester of m-phenoxyphenyl alcohol or its .alpha.-cyano or .alpha.-ethinyl derivative with an acid of the formula R.CO.sub.2 H wherein R is an alkyl group containing not more than 3 carbon atoms, and tetramethyl or tetraethyl titanate at a temperature such that the methyl or ethyl ester of the acid of formula R.CO.sub.2 H is removed by distillation as it is formed.