Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.

Abstract: A processing device in a memory sub-system determines that an amount of host data in a first portion of a memory device configured as a program buffer satisfies a buffer threshold criterion and initiates an initial program pass of first host data from the program buffer to a second portion of the memory device configured as a primary memory. The processing device further determines that the first host data is to be evicted from the program buffer, and initiating a final program pass of the first host data from the program buffer to the primary memory.

Abstract: An irradiation device for additively manufacturing three-dimensional objects may include a beam generation device configured to generate an energy beam, an optical modulator including a micromirror array disposed downstream from the beam generation device, and a focusing lens assembly disposed downstream from the optical modulator. The micromirror array may include a plurality of micromirror elements configured to reflect a corresponding plurality of beam segment of the energy beam along a beam path incident upon the focusing lens assembly. The focusing lens assembly may include one or more lenses configured to focus the plurality of beam segments such that for respective ones of a plurality of modulation groups including a subset of micromirror elements, a corresponding subset of beam segments are focused to at least partially overlap with one another at a combination zone corresponding to the respective modulation group.

Abstract: The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: A method, computer program product, and computing system for generating a plurality of trained machine learning models using a cloud computing system by training a plurality of machine learning models to forecast storage performance for one or more storage objects of a storage system, wherein the cloud computing system is separate from any storage system. A trained machine learning model is selected from the plurality of trained machine learning models to deploy to a target storage system. The trained machine learning model is deployed on the target storage system.

Abstract: Pixelated-LED chips include substrate sidewalls with sidewall involutions and/or increased sidewall surface area regions to affect light extraction therefrom. A LED lighting device incorporates a superstrate that supports lumiphoric material and includes sidewalls with sidewall involutions and/or increased sidewall surface area regions. Methods for fabricating sidewall features may include etching (e.g., deep etching) of substrate or superstrate materials, such as by using an etch mask having edges with non-linear shapes to produce and/or enhance sidewall involutions when an etchant is supplied through the etch mask to selectively consume substrate or superstrate material.

Abstract: Systems and methods are disclosed for automated industrial hygiene assessment and display comprising receiving sampling results for a stressor, such as a harmful environmental artifact in a physical environment; deriving one or more codes for the stressor from a digital record via an indexing module and/or from other data sources; generating a health effect rating (HER) based on the code; generating an exposure rating (ER) based on the sampling results; generating an uncertainty rating (UR) based on the sampling results; displaying, an interactive UIto facilitate approval or selection of at least one of the HER, the ER, or the UR; generating at least one of a risk rating (RR) or an information gathering priority rating (IGPR) based on a selection of the at least one of the HER, the ER, or the UR; and displaying via the interactive UI at least one of the RR or the IGPR.

Abstract: In one general aspect, a method can include displaying, on a display device included in a computing device, content in an application executing on the computing device. The method can further include displaying, in a user interface on the display device, at least one identifier, receiving a selection of the at least one identifier, and initiating casting in response to receiving the selection of the at least one identifier.

Abstract: Disclosed herein are immune activating conjugates with immunogenic carrier proteins coupled to hapten and immune cell receptor agonist-containing polymers. The polymers promote uptake by B cells, enabling intracellular immune cell receptor activation and formation of long-lived antibody-secreting cells. In some aspects, disclosed herein in is a conjugate comprising an immunogenic carrier protein coupled to a polymer, wherein the polymer includes: i) a first monomeric unit comprising a first monomer coupled to a hapten, and ii) a second monomeric unit comprising a second monomer coupled to an immune cell receptor agonist.

Abstract: Systems and methods are disclosed including a memory and a processing device operatively coupled to the memory. The processing device can perform operations including identifying a set of logical addresses associated with data stored on the memory devices in one or more blocks of a first type; determining a temporal metric class associated with the set of logical addresses, wherein the temporal metric class is associated with a corresponding range of predicted update characteristic of the data; identifying, based on the temporal metric class, a set of blocks of a second type, wherein a first block of the first type comprises a first plurality of memory cells having a first number of bits per cell, and wherein a second block of the second type comprises a second plurality of memory cells having a second number of bits per cell that exceeds the first number of bits per cell; and moving the data to the identified set of blocks.

Abstract: In one aspect, a portable electronic device is provided for accessing a secured area to deliver a package therein. The portable electronic device includes a sensor configured to detect an indicium of the package and communication circuitry configured to communicate a message to a server computer associated with the package upon the sensor detecting the indicium. The communication circuitry is further configured to receive delivery information from the server computer, the delivery information including at least a location of the secured area. The portable electronic device further includes a processor operatively coupled to the sensor and the communication circuitry. The processor is configured to cause, via the communication circuitry, the movable barrier operator to open a movable barrier associated with the secured area.

Abstract: The present disclosure relates to servers, systems, and methods for dynamic risk evaluation using weighted factors. It introduces a decision intelligence-based framework for assessing risk. Traditional methods face challenges like limited data, biases, and static assessments, where the system described herein leverages advanced data analytics, machine learning, and/or predictive modeling to enhance accuracy and personalization. In some embodiments, the system is configured to enable users to enter parameters, targeting criteria, and/or factors for tracking. The system performs risk determination, outputs premiums, and automatically monitors changes in factors over time. In some embodiments, the system enables weightings for factors to be applied automatically, where in some embodiments, AI model are configured to generate the weightings based on predictions. Example factors include heart rate, BMI, and sleep time.

Abstract: A breakaway medical connector can include a housing with engagement features that interface with corresponding engagement features on a breakaway member so that the breakaway is attached to the housing. A second connector can couple to the breakaway member to provide a fluid connection between the first connector and the second connector. If a force above a threshold is applied that pulls the second connector apart from the breakaway connector, the engagement features can be overcome and the breakaway member can detach from the housing. The second connector can detach from the first connector along with the breakaway member. The connector can have a valve that closes the fluid pathway upon the separation of the breakaway member from the housing. The connector can impede reconnection after the breakaway disconnection. The connector can permit reconnection using a tool that disinfects the connector.

Abstract: A dryer appliance, a controller, and a method for operation are provided. The controller is configured to execute steps of a method including receiving an input indicative of a drying cycle end time; determining a moisture extraction rate based at least in part on the received input indicative of drying cycle end time, the moisture extraction rate indicative of a rate at which moisture is removed from articles within a chamber of the dryer appliance; determining a rate of change of moisture extraction rate corresponding to the drying cycle end time; and adjusting a condensation rate based at least on the rate of change of moisture extraction rate and the received input indicative of the drying cycle end time.

Abstract: This disclosure provides systems, apparatuses, and methods for liquid transfer and performing reactions. In one aspect, a system includes a liquid transfer device having a housing having a pipette tip and a plunger assembly; and a reaction chamber, wherein the housing of the liquid transfer device is configured to sealably engage with the reaction chamber. In another aspect, a liquid transfer device including a housing having a pipette tip; and a plunger assembly disposed within the housing and the pipette tip, wherein a portion of the plunger assembly is configured to engage a fluid reservoir such that the plunger assembly remains stationary relative to the fluid reservoir and the housing moves relative to the plunger assembly.

Abstract: Systems and methods of injecting hydrate inhibiting chemicals into a gaseous fuel line of a burner are described. One system includes: an oilfield burner; a gaseous fuel line connected to the oilfield burner; a storage tank containing hydrate-inhibiting chemicals; a hydrate-inhibiting chemical supply line connected between the storage tank and the gaseous fuel line; and a control valve connected to control flow in the hydrate-inhibiting chemical supply line in response to the operation of the oilfield burner. A kit may be provided with at least the hydrate-inhibiting chemical supply line and control valve.

Abstract: The present invention is directed in part to soybean variety AR1403091, EE1600274, EE1600891, EE1660258, EE1760174, EE1760847, and/or EE1761104 breeding and development. The present invention particularly relates to soybean variety AR1403091, EE1600274, EE1600891, EE1660258, EE1760174, EE1760847, and/or EE1761104 and its seed, cells, germplasm, plant parts, and progeny, and methods of using AR1403091, EE1600274, EE1600891, EE1660258, EE1760174, EE1760847, and/or EE1761104, e.g., in a breeding program.

Abstract: Disclosed herein are switching or other active FET configurations that implement a branch design with one or more interior FETs of a main path coupled in parallel with one or more auxiliary FETs of an auxiliary path. Such designs include a circuit assembly for performing a switching function that includes a branch with a plurality of auxiliary FETs coupled in series and a main FET coupled in parallel with an interior FET of the plurality of auxiliary FETs. The body nodes of the FETs can be interconnected and/or connected to a body bias network. The body nodes of the FETs can be connected to body bias networks to enable individual body bias voltages to be used for individual or groups of FETs.

Abstract: Methods for management of encoding complexity for image and video encoding, for example for algorithms belonging to the JPEG 2000 family of standards, where the encoding process targets a given compressed size (i.e. a total coded length) for the image or for each frame of a video sequence. A set of methods for complexity constrained encoding of HTJ2K code-streams, involving collection of local or global statistics for each sub-band (not for each code-block), generation of forecasts for the statistics of sub-band samples that have not yet been produced by spatial transformation and quantization processes, and the use of this information to generate a global quantization parameter, from which the coarsest bit-plane to generate in each code-block can be deduced. Coded length estimates can be generated in a manner that enables latency and memory to be separately optimized against encoded image quality, while maintaining low computational complexity.