Patents by Inventor David A. Selinger
David A. Selinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11242535Abstract: The invention relates to gene expression regulatory sequences, specifically introns that act as enhancers of gene expression, the promoter and terminator sequences endogenously associated with these introns. Presence of these intronic enhancer sequences in proximity to promoter sequences leads to enhancement of gene expression. Methods of finding such new intronic enhancer sequences and using them to generate transgenic plants are also described.Type: GrantFiled: June 3, 2019Date of Patent: February 8, 2022Inventors: Scott Diehn, Ajit Nott, David A Selinger, Carl Simmons, Priyanka Bhyri, Venkata S Tavva
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Patent number: 10344290Abstract: The invention relates to gene expression regulatory sequences, specifically introns that act as enhancers of gene expression, the promoter and terminator sequences endogenously associated with these introns. Presence of these intronic enhancer sequences in proximity to promoter sequences leads to enhancement of gene expression. Methods of finding such new intronic enhancer sequences and using them to generate transgenic plants are also described.Type: GrantFiled: July 26, 2017Date of Patent: July 9, 2019Assignees: E I DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Scott Diehen, Ajit Nott, David A. Selinger, Carl Simmons, Priyanka Bhyri, Venkata S. Tavva
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Patent number: 8735652Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (USX) genes.Type: GrantFiled: September 13, 2012Date of Patent: May 27, 2014Assignee: Pioneer Hi-Bred International IncInventors: Xiaoming Bao, George W Singletary, Deborah J Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A Selinger
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Publication number: 20130254932Abstract: The invention relates to gene expression regulatory sequences from maize, specifically to a promoter sequence and an intron sequence, that are useful for expressing transgenes in transgenic plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter and intron sequences, and methods for preparing and using the same.Type: ApplicationFiled: December 21, 2011Publication date: September 26, 2013Applicant: E.I. DU PONT DE NUMOURS AND COMPANYInventors: Ajit Nott, David A. Selinger, Venkata S. Tavva
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Publication number: 20130145502Abstract: The invention relates to gene expression regulatory sequences, specifically introns that act as enhancers of gene expression, the promoter and terminator sequences endogenously associated with these introns. Presence of these intronic enhancer sequences in proximity to promoter sequences leads to enhancement of gene expression. Methods of finding such new intronic enhancer sequences and using them to generate transgenic plants are also described.Type: ApplicationFiled: June 9, 2011Publication date: June 6, 2013Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: Scott Diehn, Ajit Nott, David A. Selinger, Carl R. Simmons, Priyanka Bhyri, Venkata S. Tavva
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Publication number: 20130014290Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (USX) genes.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: PIONEER HI BRED INTERNATIONAL, INCInventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 8293973Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: GrantFiled: August 2, 2011Date of Patent: October 23, 2012Assignee: Pioneer Hi Bred International IncInventors: Xiaoming Bao, George W Singletary, Deborah J Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A Selinger
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Patent number: 8173866Abstract: The present invention provides compositions and methods for manipulation of plant arabinoxylose and plant xylan synthases. Compositions include novel nucleotide sequences encoding xylan synthases and biologically active variants thereof. The invention also includes the discovery xylan synthase activity is a property of CslA polypeptides. Further provided are methods for xylose manipulation using the sequences disclosed herein. One method comprises stably incorporating into the genome of a plant cell, a CslA encoding nucleotide sequence operably linked to a heterologous promoter and regenerating a stably transformed plant. Methods for enhancing digestibility of plants and improving gum production in plants are also provided.Type: GrantFiled: January 12, 2009Date of Patent: May 8, 2012Assignee: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, Kanwarpal S. Dhugga, Deborah J. Wetterberg, David A. Selinger, Rajeev Gupta
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Publication number: 20120005780Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: ApplicationFiled: August 2, 2011Publication date: January 5, 2012Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 8017831Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: GrantFiled: June 18, 2009Date of Patent: September 13, 2011Assignee: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 7964770Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions are novel nucleotide sequences for a tissue preferred promoter isolated from the sorghum ?-kafirin coding region. The sequences drive expression preferentially to endosperm tissue. A method for expressing a nucleotide sequence in a plant using the regulatory sequences disclosed herein is provided. The method comprises transforming a plant cell to comprise a nucleotide sequence operably linked to one or more of the regulatory sequences of the present invention and regenerating a stably transformed plant from the transformed plant cell.Type: GrantFiled: September 24, 2008Date of Patent: June 21, 2011Assignee: Pioneer Hi-Bred International, Inc.Inventors: Shane E. Abbitt, Rudolf Jung, David A. Selinger
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Patent number: 7847160Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions are novel nucleotide sequences for a tissue preferred promoter isolated from the sorghum ?-kafirin coding region or from the sorghum ?-kafirin coding region. The sequences drive expression preferentially to endosperm tissue. A method for expressing a nucleotide sequence in a plant using the regulatory sequences disclosed herein is provided. The method comprises transforming a plant cell to comprise a nucleotide sequence operably linked to one or more of the regulatory sequences of the present invention and regenerating a stably transformed plant from the transformed plant cell.Type: GrantFiled: June 25, 2008Date of Patent: December 7, 2010Assignee: Pioneer Hi-Bred International, Inc.Inventors: Shane E. Abbitt, Rudolf Jung, David A. Selinger
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Publication number: 20090260105Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: ApplicationFiled: June 18, 2009Publication date: October 15, 2009Applicant: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Patent number: 7592505Abstract: The present disclosure concerns methods and compositions relating to UXS polypeptides and/or nucleic acids encoding UXS polypeptides. In certain claims, the methods and compositions are of use to improve digestibility and/or ease of grain processing. Such improvements relate to a modulation in arabinoxylan and/or hemicellulose content in transgenic plants. Such plants can, for example, comprise one or more nucleic acid sequences that inhibit expression of one or more UDP-Xylose Synthase (UXS) genes.Type: GrantFiled: December 21, 2006Date of Patent: September 22, 2009Assignee: Pioneer Hi-Bred International, Inc.Inventors: Xiaoming Bao, George W. Singletary, Deborah J. Wetterberg, Ramesh Nair, Kanwarpal S. Dhugga, Matthias Liebergesell, David A. Selinger
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Publication number: 20090188003Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions comprise novel polypeptides involved in modulating gene expression in response to abiotic stress such as cold or drought, and the polynucleotides encoding the polypeptides. Methods for expressing the polynucleotides in a plant and improving cold and/or drought tolerance of plants are also provided.Type: ApplicationFiled: January 23, 2009Publication date: July 23, 2009Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Shoba Sivasankar, David A. Selinger, Norbert Brugiere
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Publication number: 20090089897Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions are novel nucleotide sequences for a tissue preferred promoter isolated from the sorghum ?-kafirin coding region. The sequences drive expression preferentially to endosperm tissue. A method for expressing a nucleotide sequence in a plant using the regulatory sequences disclosed herein is provided. The method comprises transforming a plant cell to comprise a nucleotide sequence operably linked to one or more of the regulatory sequences of the present invention and regenerating a stably transformed plant from the transformed plant cell.Type: ApplicationFiled: September 24, 2008Publication date: April 2, 2009Inventors: Shane E. Abbitt, Rudolf Jung, David A. Selinger
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Publication number: 20090049571Abstract: The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. Compositions are novel nucleotide sequences for a tissue preferred promoter isolated from the sorghum ?-kafirin coding region or from the sorghum ?-kafirin coding region. The sequences drive expression preferentially to endosperm tissue. A method for expressing a nucleotide sequence in a plant using the regulatory sequences disclosed herein is provided. The method comprises transforming a plant cell to comprise a nucleotide sequence operably linked to one or more of the regulatory sequences of the present invention and regenerating a stably transformed plant from the transformed plant cell.Type: ApplicationFiled: June 25, 2008Publication date: February 19, 2009Inventors: Shane E. Abbitt, Rudolf Jung, David A. Selinger