Patents by Inventor David A. Six

David A. Six has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibition of phospholipase A2 mediated inflammation
    Patent number: 7745489
    Abstract: Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provided.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: June 29, 2010
    Assignee: The Regents of the University of California
    Inventors: Edward Dennis, Tony Yaksh, Karin Killermann Lucas, Camilla Svensson, David A. Six, George Kokotos, Violetta Constantinou-Kokotou
  • Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release
    Publication number: 20080319065
    Abstract: Phospholipase A2 (PLA2) forins are expressed in spinal cord whose inhibition induces a potent antihyperalgesia. PLA2 inhibitor compounds are provided that include a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four carbon tether. The compounds block Group IVA calcium dependent PLA2 (cPLA2) and/or Group VIA calcium independent PLA2 (iPLA2) and/or Group V secreted PLA2 (sPLA2).
    Type: Application
    Filed: August 17, 2006
    Publication date: December 25, 2008
    Inventors: Edward Dennis, Tony Yaksh, Karin Killerman Lucas, Camilla Svensson, David A. Six, George Kokots, Violetta Constantinou-Kokotou