Patents by Inventor David A. Smith
David A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964676Abstract: A control command is provided to a vehicle control module that identifies one or more vehicle actions to be performed by the vehicle control module to control a position of an autonomous vehicle (AV) with respect to an external environment. Whether one or more conditions pertaining to the position of the AV with respect to the external environment are satisfied is determined. Responsive to determining that the one or more conditions pertaining to the position of the AV with respect to the external environment are satisfied, a first instruction is provide to the vehicle control module that permits the vehicle control module to deviate from the one or more vehicle actions identified in the control command and to perform an energy saving action with respect to the AV.Type: GrantFiled: December 11, 2020Date of Patent: April 23, 2024Assignee: Waymo LLCInventors: David Smith, Christopher Bowen
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Patent number: 11964989Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 20, 2022Date of Patent: April 23, 2024Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.Inventors: Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson, Matthew Arnold Marx, Christopher Ronald Smith, Shelley Allen, James F. Blake, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Macedonio J. Mejia, Brad Newhouse, Phong Nguyen, Jacob Matthew O'Leary, Spencer Pajk, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P.A. Vigers, Qian Zhao, Dean Russell Kahn, John Gaudino, Michael Christopher Hilton
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Patent number: 11963962Abstract: Reanalysis of the SIMPLIFY 1 and 2 trials data indicates MMB is effective in JAKi-naïve patients and in second line therapy to RUX, providing benefits of reducing enlarged spleens, improving myelofibrosis-related symptoms, and increasing transfusion independence in patient at risk for thrombocytopenia from the underlying disease and RUX therapy. Accordingly, methods of treating myeloproliferative neoplasms (MPN) such as myelofibrosis are described. The methods can include administering a therapeutically effective amount of momelotinib or a pharmaceutically acceptable salt thereof to a subject identified as having (i) myelofibrosis and (ii) a platelet count of less than 150×109/L.Type: GrantFiled: August 21, 2019Date of Patent: April 23, 2024Assignee: GLAXOSMITHKLINE LLCInventors: Barbara Jane Klencke, Gregg David Smith, Rafe Michael Joseph Donahue
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Publication number: 20240128765Abstract: A method of cell balancing for a battery comprising a plurality of cells. The method comprises determining a cell balancing strategy based on at least one of a cell chemistry of the battery; an expected use cycle of the battery; and a first state of the battery, wherein the first state is a detected state of the battery. The method further comprises discharging one or more cells according to the cell balancing strategy when the battery is in a second state, wherein the second state is a detected state of the battery. The cell balancing strategy is configured to discharge one or more of the plurality of cells such that a balancing parameter of each cell being discharged reaches a threshold value. The balancing parameter comprises at least one of a voltage; a state of charge; and a voltage difference.Type: ApplicationFiled: September 29, 2023Publication date: April 18, 2024Applicant: Caterpillar Inc.Inventors: James Kieran MCCLOSKEY, Alexander C. CROSMAN, V.Kameswara Kiran RAJALA, Srihari Ranganathan N., Michael David SMITH
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Publication number: 20240122617Abstract: Variations of integral navigation controls may be used in conjunction with a medical instrument to provide navigation functions for an image guided surgery (IGS) system that is in communication with the integral navigation controls. In some variations, a medical instrument with integrated navigation wheels allows movement of a cursor of the IGS system along the x and y axis by scrolling the wheel, or allows selection, zooming, or other controls by combined clicking and/or scrolling of wheels, and may be sterilized or discarded along with the device. In some other variations, a control overlay may be temporarily attached to the medical instrument to provide additional controls, such as buttons or a pointing stick, and then removed and sterilized or discarded after a procedure. In each variation, inputs may be communicated via wire or wirelessly to an IGS system to provide navigation of images during a surgical procedure.Type: ApplicationFiled: December 28, 2023Publication date: April 18, 2024Inventors: Jetmir Palushi, Itzhak Fang, Ehsan Shameli, David A. Smith, JR., Fatemeh Akbarian, Henry F. Salazar, John H. Thinnes, JR., Hany Abdelwahed, Babak Ebrahimi, Oleg Dulger
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Publication number: 20240122909Abstract: The present invention relates to treatments of hereditary angioedema (HAE). In particular, the present invention provides on-demand treatments of hereditary angioedema (HAE) by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand.Type: ApplicationFiled: February 9, 2022Publication date: April 18, 2024Inventors: Edward Paul FEENER, Sally Louise MARSH, Andreas MAETZEL, Michael David SMITH, Christopher Martyn YEA
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Patent number: 11959894Abstract: LC techniques are disclosed. The LC technique includes providing a liquid chromatography system having a coated metallic fluid-contacting element, and transporting a fluid to contact the coated metallic fluid contacting element. Conditions for the transporting of the fluid are selected from the group consisting of the temperature of the fluid being greater than 150 degree Celsius, pressure urging the fluid being greater than 60 MPa, the fluid having a protein-containing analyte incompatible with one of titanium and polyether ether ketone, the fluid having a chelating agent incompatible with the one or both of the titanium or the polyether ether ketone.Type: GrantFiled: February 22, 2019Date of Patent: April 16, 2024Assignee: Silcotek CorpInventors: Jesse Bischof, Lucas D. Patterson, Gary Barone, Min Yuan, David A. Smith
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Patent number: 11957837Abstract: A method is provided for reducing the risk of sustaining a traumatic brain injury caused by a traumatic event that includes identifying a subject at risk of sustaining a traumatic brain injury, and then precisely increasing the partial pressure of carbon-dioxide (CO2) in the blood of the subject (pCO2). This method can be applied to raise the CO2 and pCO2 to improve orthostatic hypotension in conditions such as dysautonomias (like Positional Orthostatic Tachycardic Syndrome POTS) and to facilitate the drive to breathe in conditions like Central Sleep Apnea (CSA) and Sudden Infant Death Syndrome (SIDS). The pCO2 of the person is increased by placing a breathing apparatus over the mouth of the person through which the person must breath, wherein the breathing apparatus includes an enlarged dead space volume in which expired CO2 collects to be inhaled or re-breathed by the person on the next inhalation.Type: GrantFiled: May 1, 2018Date of Patent: April 16, 2024Inventor: David Smith
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Patent number: 11958010Abstract: Disclosed is a thermal desorber assembly for desorbing substances collected on a high-volume sampling (HVS) filter. The assembly includes, among other elements, a filter holder for securing a HVS filter within the assembly, a desorber body, and an insulating enclosure. The design of the thermal desorber assembly is such that it can accommodate a variety of different types of HVS filter media. Also described herein is a system comprising the thermal desorber assembly and method of using the assembly.Type: GrantFiled: August 6, 2021Date of Patent: April 16, 2024Assignees: Signature Science, LLC, Government of the United States of America, as represented by the Secretary of Homeland SecurityInventors: Joseph A. DiCicco, Paul M. Flanigan, IV, David Perry, John Brady, Barry Smith
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Publication number: 20240116638Abstract: An aircraft includes external structures, and one or more thermal emitters integrated with one or more of the external structures. The one or more thermal emitters are configured to generate heat to deice the one or more external structures. The one or more thermal emitters are configured to receive electrical power from one or more of an auxiliary power unit of the aircraft, a power distribution system of the aircraft, one or more engines of the aircraft, or an external power cart that is separate and distinct from the aircraft.Type: ApplicationFiled: October 7, 2022Publication date: April 11, 2024Applicant: THE BOEING COMPANYInventors: Mark Everette Albrecht, Richard John Loftis, Marcus Anthony Belcher, Edwin John Smith, Kristofer Logan Peterson, Collin William Childs, Benjamin David Walker, Jonathan William Udell, Doria Pei, Robert N. Jaeger, Sara Jane Lynn, Mirza Mustafayev, Ignas Sabet-Kazilas, Varun Suri
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Publication number: 20240117495Abstract: Cold thermal chemical vapor deposition coatings, articles, and processes are disclosed. Specifically, a cold thermal chemical vapor deposition process includes positioning an article, heating a precursor gas to at least a decomposition temperature of the precursor gas to produce a deposition gas, introducing the deposition gas to a coating vessel, and depositing a coating from the deposition gas onto the article within the coating vessel. The article remains at a temperature below the decomposition temperature throughout the introducing and depositing of the deposition gas. The coating on the article has a gradient formed by the depositing of the coating having no flow for a period of time. The coated article includes a thermally-sensitive substrate (the thermally-sensitive substrate capable of being modified by a temperature of 300 degrees Celsius) and a coating the thermally-sensitive substrate.Type: ApplicationFiled: October 13, 2020Publication date: April 11, 2024Inventors: Geoffrey K. WHITE, Nicholas P. DESKEVICH, James B. MATTZELA, Gary A. BARONE, David A. SMITH, Pierre A. LECLAIR, Min YUAN, Jesse BISCHOF
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Publication number: 20240115118Abstract: An endoscope comprises a handpiece housing, an elongate flexible shaft extending from the handpiece housing, a pull wire extending from the handpiece housing into the elongate flexible shaft, and a tensioning mechanism configured to adjust tension in the pull wire. A method for adjusting tension in a pull wire of a controller for an endoscope comprises preparing an endoscope for use before a procedure, adjusting tension in a pull wire for deflecting a flexible elongate shaft of the endoscope to reduce knob dwell, and performing an endoscopic procedure with the endoscope.Type: ApplicationFiled: April 25, 2023Publication date: April 11, 2024Inventors: Robert E. Ailinger, Kelly David Christensen, Justin Garth Tidwell, Derek Alder Hutchison, Spence Edward Cornia, Dustin Edward Gorringe, Jeffrey C. Smith
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Patent number: 11955116Abstract: Content is organized for brands by selecting a plurality of brand templates. After each selection, a set of properties is generated by applying a portion of settings of the respective brand template, with the remaining settings being overridden with settings for a channel communicating one of a plurality of presentations to a node of a network involved in the communication. The plurality of presentations may include different renditions of the same content. The properties may include sections configured for different focus areas and/or types of content associated with at tags to enable brand-level-targeting. Filters may be identified in the properties. Based on each of the identifications, a property from among the generated sets of properties may be selected based on comparisons with the associated tags.Type: GrantFiled: January 6, 2021Date of Patent: April 9, 2024Assignee: Sinclair Broadcast Group, Inc.Inventors: Benjamin Aaron Miller, Jason D. Justman, Lora Clark Bouchard, Michael Ellery Bouchard, Kevin James Cotlove, Mathew Keith Gitchell, Stacia Lynn Haisch, Jonathan David Kersten, Matthew Karl Marchio, Peter Arthur Pulliam, George Allen Smith, Todd Christopher Tibbetts
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Publication number: 20240112228Abstract: Systems and methods are described for generating efficient iterative electronic recommendation structures. In various aspects, one or more processors aggregate a plurality of ratings vectors, where each ratings vector is associated with a vector type and contains one or more content ranking metrics associated with one or more users. The one or more processors generate similarity pairing values from the plurality of ratings vectors, where each similarity pairing value is based on a similarity mapping between a first ratings vector and a second ratings vector. The one or more processors further generate an electronic recommendation structure based on the similarity pairing values, where the electronic recommendation structure includes a bi-directional look-up interface that is configured to return a bi-directional recommendation value after receiving a lookup request for either the vector type of the first ratings vector or the vector type of the second ratings vector.Type: ApplicationFiled: December 4, 2023Publication date: April 4, 2024Inventors: Taylor Griffin Smith, Jason Matthew White, Joseph David Albright, Tim G. Sanidas
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Publication number: 20240113974Abstract: Mobile management method, system and client. Method includes receiving a DNS query for a host name from an application on client; retrieving reputation data associated with host name from a local cache on client; and determining a policy based on host name and the reputation data. Based on determined policy for the host name, blocking attempted network flows to a host corresponding to host name to produce blocked attempted network flows. Method also includes sending attempted network flow metadata related to the blocked attempted network flows to a collector on client; transmitting the attempted network flow metadata from the collector to a VPN server pool via a VPN tunnel; and producing an anomaly report from the transmitted attempted network flow metadata. The anomaly report includes at least one of anomalies, cohorts, trends, location boundaries, detected network security issues, detected compromised clients and/or optimized network usage.Type: ApplicationFiled: November 30, 2023Publication date: April 4, 2024Applicant: MOBILE SONIC, INC.Inventors: Joseph T. SAVARESE, Steven HECKT, Michael E. BRYANT, Eric C. MCNEILL, Carter SMITH, Elizabeth KIHSLINGER, Thomas Gunther HELMS, Camilla KEENAN-KOCH, Joseph G. SOUZA, Paul HOOVER, S. Aaron STAVENS, Christian E. HOFSTAEDTER, Jonathan SCOTT, Erik OLSON, James Scott SIMPKINS, Stephen Gregory FALLIN, John Harvey HILLOCK, Eivind NAESS, Michael Lee SNYDER, David Michael MIRLY, Marius LEE, Glenn Patrick ARANAS, Norman C. HAMER, Tridib DUTTA, Andrew James HOOVER, Thomas A. SWEET, Mark ANACKER, An PHAN
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Publication number: 20240109462Abstract: A vehicle seat and storage system includes a vehicle seat having a seat base and a seat back extending from the seat base. A storage apparatus is connected to the seat back and is movable from a stowed position against the seat back to an extended position away from the seat back. The storage apparatus is configured to position and secure one or more cargo items. A seat motor is operably connected to the seat. The seat motor is configured to move the seat back from a first position extending upward from the seat base to a second position where the seat back is disposed flat against the seat base.Type: ApplicationFiled: September 28, 2022Publication date: April 4, 2024Inventors: Patrick Minjeur, David M. Aller, Christopher Stephen Flemming, Lisa M. Simms, John Joseph Katona, Owen Rauch, Siddhant Kansal, Zachariah Smith, Paul W. Alexander
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Patent number: 11946339Abstract: A valve arrangement is for a downhole apparatus having a tubular body having first and second ports in a wall thereof. The valve arrangement comprises a valve member that comprises a first port associated with the first port of the tubular body; and a second port associated with the second port of the tubular body. The valve arrangement is configurable to be locked in a first configuration with the tubular body, such that the first port is closed and the second port is closed. The valve arrangement is configurable to be locked in a second configuration with the tubular body, such that the first port is open and the second port is closed. The valve arrangement is configurable to be locked in a third configuration with the tubular body, such that the first port is closed and the second port is open.Type: GrantFiled: December 14, 2022Date of Patent: April 2, 2024Assignee: Halliburton Manufacturing and Services LimitedInventors: Stephen Edmund Bruce, David Grant, Scott E. Wallace, Ewan Smith
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Patent number: 11944553Abstract: Disclosed herein are expanding spinal fusion cage embodiments including an expandable cage assembly configured to expand from a collapsed state to an expanded state in an intervertebral space when inflated with a material. The assembly can include an inflatable section defining an interior volume configured to receive the material and expand the interior volume in response to a pressure from the received material to cause the expandable cage assembly to transition from the collapsed state to the expanded state, and a stabilization section configured to restrain the inflatable section during inflation.Type: GrantFiled: January 8, 2021Date of Patent: April 2, 2024Assignees: DePuy Synthes Products, Inc., Stratasys, Inc.Inventors: Peyton Hopson, Hassan Serhan, Eric Buehlmann, Robert Sommerich, Thomas Gamache, Cynthia Star, Philip Reeves, Oliver Smith, David Hayden, Loic Le Merlus
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Publication number: 20240101497Abstract: A method for producing an olefin product, including the steps of converting a hydrocarbon feedstock to an unsaturated hydrocarbon stream through a steam cracking process in an olefins production plant; combusting hydrogen to provide at least some of the heating duty to the steam cracking process, wherein the hydrogen has a carbon intensity less than about 1.0 kg CO2e/kg H2, wherein the hydrogen is produced using a hydrogen production process; providing at least some of the required energy for the hydrogen production process from a biomass power plant; and processing the unsaturated hydrocarbon stream to recover the olefin product. The olefin product may comprise ethylene having a well-to-gate carbon intensity less than about 0.6 kg CO2e/kg C2H4, or may comprise propylene having a well-to-gate carbon intensity less than about 0.6 kg CO2e/kg C3H6.Type: ApplicationFiled: September 25, 2023Publication date: March 28, 2024Inventors: Christopher Michael MILLER, Gregory David SMITH, Anna Louise BUCKLEY, Byron Gladus BEST, III, Bengt Arne JARLSJO, Dainel Joseph SHAPIRO
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Patent number: D1022931Type: GrantFiled: August 2, 2021Date of Patent: April 16, 2024Assignee: Hewlett-Packard Development Company, L.P.Inventors: Vignesh Kannan, Joshua M. Yu, Matthew David Smith, Jeffrey A. Nielsen, Kenneth Duda