Abstract: The present disclosure addresses this need by providing crystalline fine particle forms of PRX-3140 potassium salt, methods for preparation and the treatment for Alzheimer's disease (AD) and other dementias affecting the cholinergic and/or serotonergic systems including post-traumatic stress disorder (PTSD). In certain aspects, the present disclosure provides novel methods of preparing the compound of Formula I thereof, or PRX-3140 potassium salts, crystalline fine particle forms of PRX-3140 potassium salt, and compositions comprising them. In certain aspects, the present disclosure provides novel crystalline fine particle form of PRX-3140 potassium salt which may provide advantages including improved bioavailability and stability relative to other crystalline or amorphous forms. In other aspects, the present disclosure provides oral dosage forms of crystalline fine particle form of PRX-3140 potassium salt and excipients with improved stability.

Abstract: The present disclosure addresses this need by providing crystalline fine particle forms of PRX-3140 potassium salt, methods for preparation and the treatment for Alzheimer's disease (AD) and other dementias affecting the cholinergic and/or serotonergic systems including post-traumatic stress disorder (PTSD). In certain aspects, the present disclosure provides novel methods of preparing the compound of Formula I thereof, or PRX-3140 potassium salts, crystalline fine particle forms of PRX-3140 potassium salt, and compositions comprising them. In certain aspects, the present disclosure provides novel crystalline fine particle form of PRX-3140 potassium salt which may provide advantages including improved bioavailability and stability relative to other crystalline or amorphous forms. In other aspects, the present disclosure provides oral dosage forms of crystalline fine particle form of PRX-3140 potassium salt and excipients with improved stability.

Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.

Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.

Abstract: The present disclosure is directed to compositions comprising encapsulated particles of diethylenetriaminepentaacetate (DTPA) and a zinc salt such as zinc acetate, and to pharmaceutical compositions comprising such encapsulated compositions. The present disclosure is also directed to methods of treatment by administering an effective amount of the compositions and pharmaceutical compositions of the present disclosure, to methods of making such encapsulated particle compositions, and to methods of making the corresponding pharmaceutical compositions.

Abstract: The present disclosure is directed to compositions comprising encapsulated particles of diethylenetriaminepentaacetate (DTPA) and a zinc salt such as zinc acetate, and to pharmaceutical compositions comprising such encapsulated compositions. The present disclosure is also directed to methods of treatment by administering an effective amount of the compositions and pharmaceutical compositions of the present disclosure, to methods of making such encapsulated particle compositions, and to methods of making the corresponding pharmaceutical compositions.

Abstract: Described herein are compositions comprising particles of poorly soluble drugs encapsulated by stabilizers. Further described are pharmaceutical compositions comprising such encapsulated compositions. Also described are methods of making such encapsulated particle compositions, and methods of making the corresponding pharmaceutical compositions. The encapsulated particle compositions described herein allow poorly soluble drugs to be administered with good bioavailability by routes that are non-invasive to patients, such as by oral administration.

Abstract: The invention relates to a credit card dialing apparatus for use in automatically dialing account numbers, security codes and phone numbers into telephones. The apparatus includes a credit card size device having a memory, encoder, speaker, microphone and switch embedded into a circuit board for inputting and outputting specific information depending on the use of the card. The circuit described accesses the account by tones or signals fed through the receiver or direct data input from a small databus. In another embodiment, a microprocessor unit having a keyboard, microprocessor memory, encoder, a speaker unit and microphone as well as an alphanumeric display is utilized. This system permits the user to input the desired numbers and provide serial dialing and identification for particular sources.

Abstract: A real-time three-dimensional display device particularly suited for medical imaging is disclosed. The device includes a plurality of individual processing elements each having an image memory for storing a mini-image of a portion of the object as viewed from any given direction and a merge control means for generating a combined image of the object including the depth thereof by selection on a pixel-by-pixel basis from each of the mini-images. In two different embodiments, priority codes are assigned to each of the processing elements reflecting the relative significance of a given pixel of the mini-image produced by a given processing element as compared to the pixels of mini-images produced by other processing elements. In one embodiment, the combined image is generated in accordance with the priority codes. In another embodiment, a Z buffer is used to provide for hidden surface removal on a pixel-by-pixel basis.

Abstract: The invention relates to a credit card dialing apparatus for use in automatically dialing account numbers, security codes and phone numbers into telephones. The apparatus includes a credit card size device having a memory, encoder, speaker, microphone and switch embedded into a circuit board for inputting and outputting specific information depending on the use of the card. The circuit described accesses the account by tones or signals fed through the receiver or direct data input from a small databus. In another embodiment, a microprocessor unit having a keyboard, microprocessor memory, encoder, a speaker unit and microphone as well as an alphanumeric display is utilized. This system permits the user to input the desired numbers and provide serial dialing and identification for particular sources.