Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: The present invention relates to vaccines comprising a ShK domain of a filarial nematode protein. These vaccines may be used for the prevention and/or treatment of filarial nematode infections. The invention also relates to novel proteins comprising a ShK domain of a filarial nematode protein and pharmaceutical compositions. The invention may be used for the prevention and/or treatment of filarial nematode infections in canine subjects, and also in human subjects.

Abstract: Nuclear magnetic resonance (NMR) relaxation and/or diffusion measurements are used to deduce fluid compositional information such as a chain-length distribution, which may then be used to predict the true boiling points (TBP) of a sample of a complex hydrocarbon fluid mixture, such as a crude oil. The NMR measurements may be considered a fast and portable proxy measurement in estimating fluid TBP distributions in lieu of distillation methods, or the simulated distillation by gas chromatography.

Abstract: A mobile device includes an originally downloaded mobile application. When a location of the mobile device is detected within a configured distance of a target enterprise store location, configuration data for the target enterprise's mobile application and services are obtained and automatically sent to the mobile device. The configuration data is applied to the original mobile application. When the user launches the original mobile application from the mobile device, the executing instance of the mobile application is transformed into the target enterprise's mobile application connected to the target enterprise's mobile application services server. The executing instance of the mobile application includes the branding, design, features, and workflow of the target enterprise's mobile application.

Abstract: Methods and systems are provided that combine NMR and IR spectroscopy measurements on a rock sample to determine data representing at least one property of the rock sample. In one embodiment, cuttings can be split into first and second lots. Results of an NMR measurement performed on the first lot of cuttings without cleaning can be analyzed to determine pore volume of the cuttings. Results of an IR spectroscopy measurement performed on the second lot of cuttings after solvent cleaning can be analyzed to determine matrix density of the cuttings. Porosity can be determined from the pore volume and matrix density of the cuttings. In another embodiment, combined NMR and IR spectroscopy measurements can be performed on an unprepared rock sample (without solvent cleaning) to characterize properties of kerogen in the rock sample and porosity. In another aspect, a method is provided that employs multi-nucleic NMR measurements to determine porosity.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: A docking station for receiving a hand-held rebound tonometer and a probe container carrying disposable tonometer probes has a docking cavity for receiving a portion of the rebound tonometer and a container receptacle for receiving the probe container. The docking station has an actuation feature arranged to move a cover associated with the probe container from a closed position to an open position as the container is inserted into the container receptacle so that tonometer probes in the container are accessible. The actuation feature may include a projection extending into an entryway leading to the container receptacle for engaging the cover but not the container, such that further insertion of the container moves the cover from the closed to the open position. The docking station may also have a storage recess for receiving an empty probe tube and cap after the probe has been removed from the tube for use.

Abstract: A wall panel may have a veneer layer, a middle layer made from magnesium oxide and an insulation layer made from a two-part rigid urethane pour foam. The insulation layer maybe chemically bonded to the middle layer. The veneer layer may include a poured substrate made from polyurethane or plastic. The veneer layer may further include aesthetic elements embedded in and bonded to the poured substrate. The aesthetic elements may include one or more of brick, ceramic tile, porcelain tile, natural stone, engineered stone, wood, ceramic, plastic, or vinyl. A finished surface of the aesthetic elements may extend above a top surface of the poured substrate. The poured substrate may include sand causing the top surface of the poured substrate to have an appearance of mortar.

Abstract: A wall panel may have a rigid layer, a first insulation layer made from a two-part rigid urethane pour foam, and a second insulation layer made from a phase change material. The first insulation layer maybe chemically bonded to the rigid layer and may also be bonded to the phase change layer. The first insulation layer may be positioned between the second insulation layer and the rigid layer. The rigid layer may be a finished surface or a veneer layer may be applied to the rigid layer.

Abstract: A touch sensor may include a substrate, a drive electrode on the substrate, a sense electrode on the substrate, and a deformable snap member disposed over the drive electrode and the sense electrode. The deformable snap member may include a deflectable metal material. When the metal material flexes from a resting position, a change in capacitance between the drive electrode and the sense electrode may be detectable.

Abstract: Systems and methods for monitoring a crude oil blending process use nuclear magnetic resonance (NMR) sensors which investigate properties of a plurality of crude oil streams that are mixed together to form a crude oil blend. An NMR sensor is also used to investigate the properties of the crude oil blend. The investigated properties may include viscosity. Resulting determinations may be used to control the input streams so that the output stream meets desired criteria. Additional sensors such as spectroscopy sensors, viscometers, and densitometers may be used in conjunction with the NMR sensors.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media, a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user, a search mechanism for searching for media and products used in media, and a video recording mechanism for recording and sharing videos of users.

Abstract: A rapid interior wall layout system can include an anchor and clasp. The anchor can have a lower portion that fits within a drywall track opening, an upper portion having an external notch, and a central opening that extends through the lower and upper portions to receive a fastener that extends through the anchor to hold the anchor in place against an existing building structure. The clasp can include a base, arms pivotally coupled to the base, tabs that extend inward from the arms, and flanges that extend from the base and arms. The clasp tabs can lock onto the external notch during installation to hold the drywall track in place against the anchor. The system can also include the drywall track itself, a second anchor for a second opening in the drywall track and a second clasp to hold the drywall track in place against the second anchor.

Abstract: A method for configuring, via a website, a computing device to communicate with a printer is described. The method includes creating, via the website, a printer definition for the printer. The printer definition includes a network address, a reference to a printer driver, and a reference to a printer profile. The method also includes sending an install uniform resource identifier (URI) associated with the printer definition. The method further includes receiving an indication that the install URI has been activated by the computing device. The method additionally includes sending an installer to the computing device. The installer installs the printer driver and configures the computing device to communicate with the printer using the network address, the printer driver and the printer profile.

Abstract: This disclosure describes a process for producing a surface-modified calcium carbonate, the process comprising contacting a calcium carbonate or precursor thereof with at least one amphiphilic copolymer comprising hydrophilic subunits and hydrophobic subunits, in which the hydrophilic subunits derive from at least one ethylenically-unsaturated compound comprising a carboxylic acid group or salt or derivative thereof; the hydrophobic subunits derive from at least one ethylenically-unsaturated compound comprising a hydrophobic group; and the amphiphilic copolymer has a hydrophilic-lipophilic balance ranging from about 1 to about 40. Surface-modified calcium carbonates obtained from the process are also described, as well as compositions containing the surface-modified calcium carbonates.

Abstract: A playback device detects a first playback condition and a second playback condition related to an identified first user of a first media playback system. The playback device identifies an audio track associated with each of the first playback condition and the second playback condition. The playback device detects a third playback condition related to a geographical location, and based on the detected third playback condition, plays back audio content beginning with the identified audio track.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media, a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user, and a search mechanism for searching for media and products used in media. A method of sharing portions of media.

Abstract: A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

Abstract: A storage system for temporary storage of a gas comprising a storage vessel configured to store a pressurized gas or liquid; at least one of a compressor configured to pressurize the gas and provide the pressurized fluid or a liquefaction apparatus operable to liquefy the gas to provide the liquid; and piping associated with one or more valves, wherein the piping and the associated one or more valves are configured to provide: (a) in a first configuration, inflow of the gas into the compressor or the liquefaction apparatus, wherein the compressor is configured to pressurize the inflowing gas to provide the pressurized fluid or wherein the liquefaction apparatus is configured to liquefy the inflowing gas to provide the liquid, and introduce the pressurized gas or the liquid into the temporary storage vessel; and (b) in a second configuration, outflow of the pressurized gas or liquid from the temporary storage vessel.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.