Patents by Inventor David A. Theilmann

David A. Theilmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insect expression vectors
    Patent number: 7135337
    Abstract: The invention provides insect shuttle vectors, and methods of using such vectors, for stably transforming disparate insect cell lines to express heterologous proteins. The invention provides a transformed insect cell selection system based on resistance to the bleomycin/phleomycin family of antibiotics, including the antibiotic Zeocin. Efficient promoters derived from baculovirus immediate early promoters are disclosed for use in directing expression of heterologous proteins, including selectable markers, in transformed insect cells of the invention. Transposon-based vectors are disclosed that provide inducible transposition to optimize heterologous protein expression and unobtrusive markers to facilitate selection of desired transformants.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: November 14, 2006
    Inventors: Tom A. Grigliatti, Tom A. Pfeifer, David A. Theilmann, Dwayne D. Hegedus
  • Translational regulatory elements
    Patent number: 6784289
    Abstract: The present invention is directed to translational regulatory elements that mediate the amount of protein produced within a host capable of expressing a construct comprising one or more translational regulatory elements in operative association with a gene of interest. These translational regulatory elements were derived from T1275 (tCUP) and exhibit a high degree of similarity with members of the RENT family of repetitive elements. Translational regulatory elements are disclosed that either increase or decrease he amount of protein produced within the host organism. These translational elements are operative in a wide range of hosts including plant, animals, yeast, fungi and bacteria. Analogs, derivatives and fragments of these translational elements are also disclosed.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 31, 2004
    Assignee: Her Majesty the Queen in Right of Canada, as represented by the Minister of Agriculture and Agri-Food
    Inventors: Thérèse Ouellet, Brian M. Miki, Elizabeth Foster, Teresa Martin-Heller, Lining Tian, Daniel C. Brown, Peijun Zhang, Jiro Hattori, Kamal Malik, Keqiang Wu, David A. Theilmann, Raymond Tropiano
  • Insect expression vectors
    Publication number: 20020116723
    Abstract: The invention provides insect shuttle vectors, and methods of using such vectors, for stably transforming disparate insect cell lines to express heterologous proteins. The invention provides a transformed insect cell selection system based on resistance to the bleomycin/phleomycin family of antibiotics, including the antibiotic Zeocin. Efficient promoters derived from baculovirus immediate early promoters are disclosed for use in directing expression of heterologous proteins, including selectable markers, in transformed insect cells of the invention. Transposon-based vectors are disclosed that provide inducible transposition to optimize heterologous protein expression and unobtrusive markers to facilitate selection of desired transformants.
    Type: Application
    Filed: June 29, 2001
    Publication date: August 22, 2002
    Inventors: Tom A. Grigliatti, Tom A. Pfeifer, David A. Theilmann, Dwayne D. Hegedus
  • Translational regulatory elements
    Publication number: 20020073444
    Abstract: The present invention is directed to translational regulatory elements that mediate the amount of protein produced within a host capable of expressing a construct comprising one or more translational regulatory elements in operative association with a gene of interest. These translational regulatory elements were derived from T1275 (tCUP) and exhibit a high degree of similarity with members of the RENT family of repetitive elements. Translational regulatory elements are disclosed that either increase or decrease he amount of protein produced within the host organism. These translational elements are operative in a wide range of hosts including plant, animals, yeast, fungi and bacteria. Analogs, derivatives and fragments of these translational elements are also disclosed.
    Type: Application
    Filed: December 21, 2000
    Publication date: June 13, 2002
    Inventors: Therese Ouellet, Brian M. Miki, Elizabeth Foster, Teresa Martin-Heller, Lining Tian, Daniel C. Brown, Peijun Zhang, Jiro Hattori, Kamal Malik, Keqiang Wu, David A. Theilmann, Raymond Tropiano