Patents by Inventor David A. Vorp
David A. Vorp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11850141Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: GrantFiled: September 20, 2019Date of Patent: December 26, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Mohammed S. El-Kurdi, William R. Wagner, David A. Vorp, John J. Stankus, Lorenzo Soletti, Jonathan McGrath, Yi Hong, J Christopher Flaherty
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Publication number: 20230285290Abstract: Provided herein is a drug delivery device and composition, such as a particle, comprising conditioned medium. Also provided herein is a method of preparing polymeric particles for release of conditioned medium. Further, a tissue growth scaffold comprising particles for release of conditioned medium is provided.Type: ApplicationFiled: May 11, 2023Publication date: September 14, 2023Inventors: Morgan Virginia Fedorchak, Jeffrey Krawiec, Steven R. Little, Katherine Lorentz, David A. Vorp, Justin Sol Weinbaum
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Patent number: 11684574Abstract: Provided herein is a drug delivery device and composition, such as a particle, comprising conditioned medium. Also provided herein is a method of preparing polymeric particles for release of conditioned medium. Further, a tissue growth scaffold comprising particles for release of conditioned medium is provided.Type: GrantFiled: June 29, 2017Date of Patent: June 27, 2023Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Svstem of Higher Education 1ttsInventors: Morgan Virginia Fedorchak, Jeffrey Krawiec, Steven R. Little, Katherine Lorentz, David A. Vorp, Justin Weinbaum
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Publication number: 20220192502Abstract: An endovascular apparatus can comprise an array of emitters configured to emit light at a predetermined wavelength and an array of sensors configured to detect light emitted by the emitters and reflected off a surface. The device can be configured to be inserted into a stent within a blood vessel of a patient and the device can be configured to detect the location of a branch blood vessel based on the reflected light detected by the array of sensors. Some devices detect light through a stent wall from an emitter positioned in the branch vessel. Some devices include fiber optics or phototransistors for receiving light from the emitter. Some devices include a fenestration former and a guidewire director along with the light receivers all in one endovascular device.Type: ApplicationFiled: April 17, 2020Publication date: June 23, 2022Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Mohammad H. Eslami, David A. Vorp, Timothy K. Chung
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Publication number: 20210338816Abstract: A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.Type: ApplicationFiled: October 18, 2019Publication date: November 4, 2021Inventors: David A. Vorp, Aneesh Krishna Ramaswamy, Justin Sol Weinbaum, Kory James Blose, Timothy Kwang-Joon Chung, Trevor Kickliter, Yogev Baruch, John A. Curci
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Publication number: 20200237494Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: ApplicationFiled: September 20, 2019Publication date: July 30, 2020Inventors: Mohammed S. El-Kurdi, William R. Wagner, David A. Vorp, John J. Stankus, Lorenzo Soletti, Jonathan McGrath, Yi Hong, J. Christopher Flaherty
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Publication number: 20190336444Abstract: Provided herein is a drug delivery device and composition, such as a particle, comprising conditioned medium. Also provided herein is a method of preparing polymeric particles for release of conditioned medium. Further, a tissue growth scaffold comprising particles for release of conditioned medium is provided.Type: ApplicationFiled: June 29, 2017Publication date: November 7, 2019Inventors: Morgan Virginia Fedorchak, Jeffrey Krawiec, Steven R. Little, Katherine Lorentz, David A. Vorp, Justin Weinbaum
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Patent number: 10239071Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.Type: GrantFiled: August 4, 2016Date of Patent: March 26, 2019Assignees: Neograft Technologies, Inc., University Of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Lorenzo Soletti, Mohammed S. El-Kurdi, Jon McGrath, Andrew Ziegler, J. Christopher Flaherty, William R. Wagner, David Vorp
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Publication number: 20170340432Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: ApplicationFiled: March 8, 2017Publication date: November 30, 2017Inventors: Mohammed S. El-Kurdi, J. Christopher Flaherty, Yi Hong, Jonathan McGrath, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
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Patent number: 9622849Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: GrantFiled: October 28, 2010Date of Patent: April 18, 2017Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Mohammed El-Kurdi, J. Christopher Flaherty, Yi Hong, Jonathan McGrath, Lorenzo Soletti, John Stankus, David Vorp, William Wagner
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Publication number: 20170043360Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.Type: ApplicationFiled: August 4, 2016Publication date: February 16, 2017Applicant: University of Pittsburgh - of the Commonwealth System of Higher EducationInventors: Lorenzo SOLETTI, Mohammed S. EL-KURDI, Jon MCGRATH, Andrew ZIEGLER, J. Christopher FLAHERTY, William R. WAGNER, David VORP
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Publication number: 20160317280Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: ApplicationFiled: March 31, 2016Publication date: November 3, 2016Inventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
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Patent number: 9445874Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.Type: GrantFiled: July 19, 2011Date of Patent: September 20, 2016Assignees: Neograft Technologies, Inc., University of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Lorenzo Soletti, Mohammed S. El-Kurdi, Jon McGrath, Andrew Ziegler, J. Christopher Flaherty, William R. Wagner, David Vorp
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Patent number: 9333068Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: GrantFiled: January 21, 2015Date of Patent: May 10, 2016Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
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Patent number: 9237945Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: GrantFiled: January 30, 2008Date of Patent: January 19, 2016Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Mohammed S. El-Kurdl, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
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Publication number: 20150150673Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: ApplicationFiled: January 21, 2015Publication date: June 4, 2015Inventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
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Publication number: 20140005470Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.Type: ApplicationFiled: July 19, 2011Publication date: January 2, 2014Applicant: NEOGRAFT TECHNOLOGIES, INC.Inventors: Lorenzo Soletti, Mohammed S. El-Kurdi, Jon McGrath, Andrew Ziegler, J. Christopher Flaherty, William R. Wagner, David Vorp
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Publication number: 20120330437Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: ApplicationFiled: October 28, 2010Publication date: December 27, 2012Applicant: Univeristy of Pittsburgh of the Commonwealth System of Highter EducationInventors: Mohammed El-Kurdi, J. Christopher Flaherty, Yi Hong, Jonathan McGrath, Lorenzo Soletti, John Stankus, David Vorp, William Wagner
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Publication number: 20080208323Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.Type: ApplicationFiled: January 30, 2008Publication date: August 28, 2008Inventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
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Publication number: 20080109070Abstract: Described herein are elastomeric materials, and in particular porous biodegradable elastomeric materials which optionally may have microintegrated cells. Also described herein are bioprosthetic devices that can be manufactured using the biodegradable elastomeric materials, non-limiting examples of such devices including pulmonary valves, vocal chords, and blood vessels.Type: ApplicationFiled: August 10, 2007Publication date: May 8, 2008Inventors: William Wagner, John Stankus, Jianjun Guan, Kazuro Fujimoto, Alejandro Nieponice, Lorenzo Soletti, David Vorp, Michael Sacks, Todd Courtney, John Mayer