Patents by Inventor David A. Williams

David A. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BCL11A microRNAs for treating hemoglobinopathies
    Patent number: 12350284
    Abstract: Embodiments herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat hemoglobinopathies, such as sickle cell disease or thalassemia, by increasing the expression levels of fetal hemoglobin levels.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: July 8, 2025
    Inventors: David A. Williams, Swaroopa Guda
  • CONSTRUCTS COMPRISING TANDEM MICRORNA-ADAPTED SHORT HAIRPIN RNA (SHMIR) FOR INCREASING FETAL HEMOGLOBIN
    Publication number: 20250034568
    Abstract: The technologies as described herein relate to compositions and methods for the treatment of hemoglobinopathies by increasing fetal hemoglobin in a subject.
    Type: Application
    Filed: October 14, 2022
    Publication date: January 30, 2025
    Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, DANA-FARBER CANCER INSTITUTE
    Inventors: David A. WILLIAMS, Daniel E. BAUER, Christian BRENDEL
  • Compositions and methods to treating hemoglobinopathies
    Patent number: 11739329
    Abstract: Embodiments herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: August 29, 2023
    Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Michael Milsom, David A. Williams, Richard Gregory
  • VECTORS AND COMPOSITIONS FOR TREATING HEMOGLOBINOPATHIES
    Publication number: 20220259594
    Abstract: The invention provides improved gene therapy vectors, compositions, and methods.
    Type: Application
    Filed: January 28, 2022
    Publication date: August 18, 2022
    Inventors: Gabor Veres, David A. Williams
  • Vectors and compositions for treating hemoglobinopathies
    Patent number: 11261441
    Abstract: The invention provides improved gene therapy vectors, compositions, and methods.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: March 1, 2022
    Assignees: bluebird bio, Inc., Children's Medical Center Corporation
    Inventors: Gabor Veres, David A. Williams
  • COMPOSITIONS AND METHODS TO TREATING HEMOGLOBINOPATHIES
    Publication number: 20220056453
    Abstract: Embodiments herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 24, 2022
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Michael MILSOM, David A. WILLIAMS, Richard GREGORY
  • Compositions and methods to treating hemoglobinopathies
    Patent number: 11124794
    Abstract: Embodiments herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat hemoglobinopathies such as sickle cell disease or thalassemia by increasing the expression levels of fetal hemoglobin levels.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: September 21, 2021
    Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Michael Milsom, David A. Williams, Richard Gregory
  • IMPROVED BCL11A MICRORNAS FOR TREATING HEMOGLOBINOPATHIES
    Publication number: 20210085707
    Abstract: Embodiments herein provide specially designed synthetic BCL11A-targeting microRNAs for RNA polymerase II expression, and methods of use to treat hemoglobinopathies, such as sickle cell disease or thalassemia, by increasing the expression levels of fetal hemoglobin levels.
    Type: Application
    Filed: April 30, 2019
    Publication date: March 25, 2021
    Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: David A. WILLIAMS, Swaroopa GUDA
  • Wheel front face
    Patent number: D959349
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: August 2, 2022
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D960064
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: August 9, 2022
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D960066
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: August 9, 2022
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Spray paint applicator
    Patent number: D964833
    Type: Grant
    Filed: May 24, 2020
    Date of Patent: September 27, 2022
    Assignee: AERVOE INDUSTRIES, INC.
    Inventors: David A. Williams, Keiran Creek
  • Wheel front face
    Patent number: D1008921
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: December 26, 2023
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1008923
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: December 26, 2023
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1009747
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: January 2, 2024
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1010535
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: January 9, 2024
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1032445
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: June 25, 2024
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1032446
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: June 25, 2024
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1032447
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: June 25, 2024
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams
  • Wheel front face
    Patent number: D1032448
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: June 25, 2024
    Assignee: WHEEL GROUP HOLDINGS, LLC
    Inventor: David A. Williams