Abstract: A system and computer-implemented method for the creation of a structure using Lego building blocks is disclosed. Aspects of the methods are equally appropriate for numerous structures, including but not limited to, studs-up and studs-out configurations or a ‘wall’ style mosaic or a ‘floor’ style mosaic. Given the systems and methods disclosed, aspects of the invention are applicable to three-dimensional sculpture structures too. The system and method may use a recursive overlapping divide-and-conquer breadth-first search feature to improve the quality of the structures while only slightly, if at all, increasing the time and memory required. Furthermore, the system and method may use dithering algorithms and/or cost analysis to determine which building block can be used and placed to achieve high-quality structures. In another example, aspects of the invention may be used to more optimally schedule delivery trucks.

Abstract: A novel class or family of TGF-? binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Abstract: A retractable awning for attachment to a golf cart is provided. The awning is comprised of a framework having a plurality of U-shaped rib members and a fabric cover. The U-shaped rib members have ends terminating at a common pivot point to allow respective relative movement to move the awning between an extended deployed position and a retracted closed position over a rear compartment of the golf cart. Each successively adjacent rib member is dimensioned slightly less than its preceding rib member to allow nesting of all the rib members in a common plane so that the framework can lie substantially flat in its retracted position. A tab on the fabric cover allows an operator to move and secure the framework between an extended position, whereat a rear portion of the cart is covered, and a retracted position, whereat the rear portion of the cart is exposed.

Abstract: Systems, methods, and computer-readable media process computer input data (such as electronic ink data, speech input data, keyboard input data, etc.), including focus change data, in a manner so that the input insertion range better comports with the user's original intent. More specifically, user input data may be accepted, before, during, and/or after a focus change event is initiated, and the systems and methods will process this input data in an intuitive manner, directing the data to areas of an application program or the operating system that better comport with the user's original intent. In this manner, loss of input data may be avoided and misdirected input data may be avoided, thereby lowering user frustration during focus change events.

Abstract: Systems, methods, and computer-readable media process computer input data (such as electronic ink data, speech input data, keyboard input data, etc.), including focus change data, in a manner so that the input insertion range better comports with the user's original intent. More specifically, user input data may be accepted, before, during, and/or after a focus change event is initiated, and the systems and methods will process this input data in an intuitive manner, directing the data to areas of an application program or the operating system that better comport with the user's original intent. In this manner, loss of input data may be avoided and misdirected input data may be avoided, thereby lowering user frustration during focus change events.

Abstract: A correction tool that displays a correction widget when a user acts to correct text is provided. More particularly, if the user places an insertion point in or to the immediate left of the text, or selects the text, the tool displays the correction widget immediately to the left of the selected text. The user can then quickly access a correction interface for correcting the text simply by moving the pointer the short distance from the insertion point to the correction widget. When the user activates the correction widget, the tool displays the correction interface immediately proximal to the correction widget. Thus, the user need only move the pointer a small distance further to then correct the text using the correction interface.

Abstract: A correction tool that displays a correction widget when a user acts to correct text is provided. More particularly, if the user places an insertion point in or to the immediate left of the text, or selects the text, the tool displays the correction widget immediately to the left of the selected text. The user can then quickly access a correction interface for correcting the text simply by moving the pointer the short distance from the insertion point to the correction widget. When the user activates the correction widget, the tool displays the correction interface immediately proximal to the correction widget. Thus, the user need only move the pointer a small distance further to then correct the text using the correction interface.

Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Abstract: Systems and methods enhance editing capabilities associated with a wide variety of different types of electronic documents. Such systems and methods may include a processor that maintains an electronic document having a first portion (e.g., an individual word, character, character string, or the like) provided by a recognizer (e.g., by handwriting or speech recognition software), and they may provide access to potential alternative characters, words, or character strings generated by the recognizer during various user editing functions and operations. Other data associated with the first portion of the document also may be stored and made available to the user during various functions and operations. This invention further relates to computer-readable media including instructions for performing various methods and/or operating various systems for editing electronic documents, including systems and methods like those described above.

Abstract: Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.

Abstract: A tool for creating integrated collections. The tool may include a “basket” control that includes interfaces for receiving and displaying the data objects that are selected by a user to be included in a collection, and a collection creation component then provides a collection with one or more data items corresponding to the objects submitted to the basket control. The basket control may be employed by itself to make collections, or it may be hosted by another software object, such as a “listmaker” control that conveniently contains both the basket control and one or more user interfaces that a user can employ to provide data objects to the basket control. The listmaker control may thus include a viewing graphical user interface for viewing data objects and a navigation toolbar for navigating the viewing graphical user interface. The listmaker control may then be hosted as desired in a variety of software applications.

Abstract: A method of inhibiting or reducing cell proliferation in a human or mammal is disclosed. This method involves administering to a human or mammal an effective amount of CoA-independent transacylase inhibiting amount of a compound of the formula disclosed in the specification.

Abstract: This invention relates to a method of treating or reducing cell proliferation in a mammal in need thereof which comprises administering to said mammal an effective CoA-independent transacylase (CoA-IT) inhibiting amount of a compound of formula (I), wherein the variables of Y, X, m, R 3, R 4, R 10, R 20, R 5, R 6 and R 7 are defined in the specification. FIG. 3 demonstrates the ability of SB216754, ((3S,4R)-4-(isobutenyloxy)-3-triphenylmethylamino)azetidin-2-one) to decrease the viability of HL-60 cells.

Abstract: This invention relates to methods for treating diseases or disorders mediated by lipid inflammatory mediators, arachidonic acid, its metabolites and/or platelet activating factor (PAF), which method comprises administration to a mammal in need thereof of an effective Coenzyme A independent transacylase (CoA-IT) inhibiting amount of a triphenylmethylazetidinone. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a triphenylmethylazetidinone.

Abstract: This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).

Abstract: Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.

Abstract: Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby.