Patents by Inventor David A. Zaharoff

David A. Zaharoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered FGF compositions and methods of use thereof
    Patent number: 10385113
    Abstract: The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 20, 2019
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Suresh Kumar Thallapuranam, David A. Zaharoff, Srinivas Jayanthi, Bhanuprasanth Koppolu, Rebecca Kerr, Kartik Balachandran, David S. McNabb
  • ENGINEERED FGF COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170281790
    Abstract: The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 5, 2017
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSA
    Inventors: Suresh Kumar Thallapuranam, David A. Zaharoff, Srinivas Jayanthi, Bhanuprasanth Koppolu, Rebecca Kerr, Kartik Balachandran, David S. McNabb
  • CYTOKINE-CHITOSAN BIOCONJUGATES AND METHODS OF USING THE SAME
    Publication number: 20170106092
    Abstract: Compositions including chitosan covalently linked to a cytokine or growth factor are provided herein. The compositions can be used to produce pharmaceutical compositions and can be used in methods of treating a variety of diseases or disorders. The compositions are especially suitable for localized delivery and may allow for intratamoral delivery and treatment of cancers or stimulation of an immune response to a co-administered antigen.
    Type: Application
    Filed: June 1, 2015
    Publication date: April 20, 2017
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: David A. Zaharoff, Suresh Kumar Thallapuranam, Bhanu prasanth Koppolu, Srinivas Jayanthi, Sean G. Smith
  • COMPOSITIONS AND METHODS FOR CHITOSAN ENHANCED IMMUNE RESPONSE
    Publication number: 20100150960
    Abstract: The present invention features methods and compositions related to chitosan antigen depots, and chitosan cytokine depots, and the use of depot compositions in treating and preventing diseases.
    Type: Application
    Filed: September 21, 2007
    Publication date: June 17, 2010
    Applicant: The United States of America, as represented by the Secretary,Department of Health and Human Servi
    Inventors: Jeffrey Schlom, David A. Zaharoff, John W. Greiner