Patents by Inventor David Aaron BUSE
David Aaron BUSE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240142486Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.Type: ApplicationFiled: September 11, 2023Publication date: May 2, 2024Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, David OPALSKY, David Aaron BUSE, Robert J. ROSATI, Olev TAMMER, Richard CAPELLA, Matthias MERTEN
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Publication number: 20240124923Abstract: A method of determining whether one or more forms of a nucleic acid analyte are present in a sample. The method includes dissolving an amplification reagent with a first solvent, where the amplification reagent contains oligonucleotides sufficient to amplify and detect a first region of a first form of the analyte, where the first solvent contains one or more oligonucleotides which, in combination with the oligonucleotides of the amplification reagent, are sufficient to amplify and detect a second region of a second form of the analyte, where the one or more oligonucleotides of the first solvent are insufficient to amplify and detect the first or second form of the analyte, and where the first and second regions each comprise a different nucleotide base sequence.Type: ApplicationFiled: July 28, 2023Publication date: April 18, 2024Inventors: Patrick L. PETERSON, Jennifer L. TIDD, Anne-Laure SHAPIRO, Ankur H. SHAH, James T. TUGGLE, David OPALSKY, Alberto A. LIO, Timothy J. SCHEER, Jason F. RHUBOTTOM, David Aaron BUSE
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Publication number: 20240093277Abstract: An automated system for performing nucleic acid amplification assays on samples provided to the system, where the system includes data input components configured to enable input specifying one or more user-defined assay parameters; data storage media storing a first set of assay parameters, the first set of assay parameters consisting of system-defined parameters, and a second set of assay parameters, the second set of assay parameters including the one or more user-defined parameters; and command input components configured to enable input specifying (i) that a first nucleic acid amplification assay be performed on a first sample in accordance with the first set of assay parameters, and (ii) that a second nucleic acid amplification assay be performed on a second sample in accordance with the second set of assay parameters.Type: ApplicationFiled: July 28, 2023Publication date: March 21, 2024Inventors: Jennifer L. TIDD, Ann-Laure SHAPIRO, Ankur H. SHAH, James T. TUGGLE, David OPALSKY, Alberto A. LIO, Timothy J. SCHEER, Jason F. RHUBOTTOM, David Aaron BUSE
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Publication number: 20240069051Abstract: A puck for removably supporting a receptacle. The puck includes a plurality of fingers arranged about a vertical axis, where each finger has a contact surface configured to be in contact with a receptacle seated in the puck. One or more springs couple the plurality of fingers, thereby biasing the fingers toward the vertical axis. The puck further includes a supporting disc having (i) a disc sidewall projecting from a base to define a pocket for seating a receptacle, (ii) a plurality of first cavities formed in the base and extending in a direction of the vertical axis, and (iii) a puck passageway extending through opposed portions of the disc sidewall in a direction transverse to and offset from the vertical axis, where each of the fingers is rotatably coupled to the supporting disc at a corresponding first cavity of the plurality of first cavities.Type: ApplicationFiled: October 18, 2023Publication date: February 29, 2024Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20240044928Abstract: A receptacle delivery system that includes a rail extending between first and second locations of an instrument and a carriage configured to move on the rail between the first and second locations of the instrument. The carriage includes a bracket having opposed first and second sidewalls and a base extending between the first and second sidewalls, where the carriage is configured to support a receptacle. The carriage further includes a pair of opposed support pads, where the pair of support pads are configured to (a) move toward a receptacle supported by the carriage as the carriage moves from the first location toward the second location, and (b) move away from a receptacle supported by the carriage as the carriage moves from the second location toward the first location. The carriage also includes a pair of meshed cam gears rotatably coupled to the first sidewall, where each cam gear is coupled to a different one of the support pads.Type: ApplicationFiled: October 18, 2023Publication date: February 8, 2024Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20240043916Abstract: A method of performing a lab developed test for detecting a nucleic acid analyte on an automated analyzer. The method includes a first step of using a computer to select, define or modify one or more user-defined parameters of a protocol for performing the lab developed test on the analyzer, where each user-defined parameter of the protocol defines a step to be performed by the analyzer during the lab developed test. The method further includes a second step of performing the lab developed test with the protocol of the first step, where the analyzer stores one or more system-defined parameters for performing the lab developed test, the one or more system-defined parameters being installed on the analyzer prior to performing first step.Type: ApplicationFiled: July 28, 2023Publication date: February 8, 2024Inventors: Jennifer L. TIDD, Ann-Laure SHAPIRO, Ankur H. SHAH, James T. TUGGLE, David OPALSKY, Alberto A. LIO, Timothy J. SCHEER, Jason F. RHUBOTTOM, David Aaron BUSE
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Patent number: 11815522Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.Type: GrantFiled: February 20, 2023Date of Patent: November 14, 2023Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
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Publication number: 20230204616Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.Type: ApplicationFiled: February 20, 2023Publication date: June 29, 2023Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
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Patent number: 11614454Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to position the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.Type: GrantFiled: December 21, 2020Date of Patent: March 28, 2023Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
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Publication number: 20220349910Abstract: A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first location.Type: ApplicationFiled: April 29, 2020Publication date: November 3, 2022Inventors: Rolf SILBERT, HongRan PENG, David Aaron BUSE, David H. COMBS
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Publication number: 20210155978Abstract: Systems and methods for performing a plurality of nucleic acid amplification assays in an automated analyzer. A first nucleic acid amplification assay of the plurality is performed in accordance with a first set of assay parameters which consist of system-defined parameters. And a second nucleic acid amplification assay of the plurality is performed in accordance with a second set of assay parameters which includes one or more user-defined parameters.Type: ApplicationFiled: July 10, 2018Publication date: May 27, 2021Applicant: Gen-Probe IncorporatedInventors: Jennifer L. TIDD, Anne-Laure SHAPIRO, Ankur H. SHAH, James T. TUGGLE, David OPALSKY, Alberto A. LIO, Timothy J. SCHEER, Jason F. RHUBOTTOM, David Aaron BUSE
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Publication number: 20210132098Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to position the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.Type: ApplicationFiled: December 21, 2020Publication date: May 6, 2021Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, David OPALSKY, David Aaron BUSE, Robert J. ROSATI, Olev TAMMER, Richard CAPELLA, Matthias MERTEN
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Patent number: 10921338Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and a drip tray movable between a first position not under the capping/decapping mechanism and a second position under the capping/decamping mechanism.Type: GrantFiled: September 11, 2018Date of Patent: February 16, 2021Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
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Patent number: 10877057Abstract: A sample container of patient sample material includes a sample container barcode containing patient-identifying information. The sample container barcode on the sample container is read, and a tubular reaction vessel is provided to a printer module configured to print a barcode directly onto a surface of the tubular reaction vessel. The printer module prints a barcode on the surface of the reaction vessel by a thermal printing method, and the barcode printed onto the reaction vessel is associated with the sample container barcode.Type: GrantFiled: June 14, 2018Date of Patent: December 29, 2020Assignee: Gen-Probe IncorporatedInventors: Rolf Silbert, David Aaron Buse, Robert J. Rosati, Olev Tammer, Matthias Merten, Richard Capella, David Opalsky
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Publication number: 20190011473Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and a drip tray movable between a first position not under the capping/decapping mechanism and a second position under the capping/decamping mechanism.Type: ApplicationFiled: September 11, 2018Publication date: January 10, 2019Applicant: Gen-Probe IncorporatedInventors: Rolf SILBERT, David OPALSKY, David Aaron BUSE, Robert J. ROSATI, Olev TAMMER, Richard CAPELLA, Matthias MERTEN
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Patent number: 10132821Abstract: The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.Type: GrantFiled: February 26, 2016Date of Patent: November 20, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
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Publication number: 20180292427Abstract: A sample container of patient sample material includes a sample container barcode containing patient-identifying information. The sample container barcode on the sample container is read, and a tubular reaction vessel is provided to a printer module configured to print a barcode directly onto a surface of the tubular reaction vessel. The printer module prints a barcode on the surface of the reaction vessel by a thermal printing method, and the barcode printed onto the reaction vessel is associated with the sample container barcode.Type: ApplicationFiled: June 14, 2018Publication date: October 11, 2018Applicant: Gen-Probe IncorporatedInventors: Rolf Silbert, David Aaron Buse, Robert J. Rosati, Olev Tammer, Matthias Merten
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Patent number: 9604185Abstract: An apparatus configured for mixing the contents of one or more fluid containers includes a fluid container support platform configured to hold one or more fluid containers. The fluid container support platform is configured to index the container to one or more specified locations and to be moved in an orbital path about an orbital center independently of the rotation about the central axis of rotation. The apparatus further includes an indexing drive system configured to effect indexing movement of the container support platform and a vortex drive system configured to effect powered orbital movement of the container support platform about the orbital center. An evaporation limiting insert placed within containers reduces exposure of the fluid contents of the container to atmospheric air, thereby reducing susceptibility of the fluid contents to evaporation.Type: GrantFiled: March 14, 2014Date of Patent: March 28, 2017Assignee: GEN-PROBE INCORPORATEDInventors: David Aaron Buse, Byron J. Knight
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Patent number: D907465Type: GrantFiled: March 7, 2019Date of Patent: January 12, 2021Assignee: GEN-PROBE INCORPORATEDInventor: David Aaron Buse
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Patent number: D907987Type: GrantFiled: March 7, 2019Date of Patent: January 19, 2021Assignee: GEN-PROBE INCORPORATEDInventor: David Aaron Buse