Abstract: Aspects are described that utilize a distributed network of measurement points to detect sources of lag in a network, but are not so limited. Sources of lag can be detected at particular locations in a network or multiple networks using a plurality of distributed measurement points. Each measurement point can be configured to monitor network conditions at a particular network location using a measurement client to perform a network testing procedure with a measurement stream. Each measurement point can also include a measurement server configured to receive a measurement stream from at least one measurement client. A controller is configured to manage and control one or more of the plurality of measurement clients using a secure connection.

Abstract: Among other things, the present disclosure provides compounds, compositions thereof, and methods of using the same. In some embodiments, compounds of the present disclosure bind to Fc receptors, e.g., CD16a. In some embodiments, compounds of the present disclosure are useful for treating various conditions, disorders or diseases including cancer.

Abstract: An example nasal airway tube includes a tubular body having a distal end and a proximal end. A surface at the distal end including an opening. The tubular body having an overall curvature with a radius of curvature defined relative to a longitudinal axis of the tube. An X-axis is defined by the longitudinal axis of the tube, and a Y-axis extends perpendicularly from the longitudinal axis and has a positive direction defined outwardly relative to the radius of curvature. At least a portion of the opening faces outwardly relative to the radius of curvature. A vector normal to a plane defined by the opening includes a positive Y-coordinate.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that identify and issue search queries expected to be issued in the future. A set of search queries that have been issued by multiple user devices can be obtained. For each query instance, contextual data can be obtained. A first query and its contextual data can be input to a model that outputs the query's likelihood of being issued in the future. The model can be trained using contextual data for training queries and a corresponding labels for the training queries. The learning model outputs the first query's likelihood of being issued in future, and this query is stored as a repeatable query if the likelihood satisfying a repeatability threshold. Subsequently, a stored repeatable query is issued upon a selection of a user selectable interface component and the search engine provides search results for the query.

Abstract: An actuator (1) comprising a motor (2) assembly, a drive coupling (113, 13, 313) assembly and an actuator shaft (114, 14). The motor (2) assembly comprising a motor housing (120, 20), having a cover (122, 22) and a base (123, 23); an electric motor (111, 11, 211, 2), comprising an external stator (111, 11, 211) and an internal rotor (112, 22); and a hollow output shaft (130, 30, 330) that is connected co-axially with the internal rotor (112, 12) such that rotation of the internal rotor (112, 12) causes a corresponding rotation of the hollow output shaft (130, 30, 330). The driving coupling (113, 13, 313) assembly comprises a drive coupling housing (115, 15, 315) containing a drive coupling (113, 13, 313), wherein the drive coupling (113, 13, 313) engages the hollow output shaft (130, 30, 330) such that rotation of the hollow output shaft (130, 30, 330) causes a corresponding rotation of the drive coupling (113, 13, 313).

Abstract: Techniques for handling natural language query processing are described. In some examples, entities are recognized during an entity recognition phase and then relations between those entities are determined. Those relations are fed to an entity linker to help the linker link candidate to columns and/or a intent representation generator to help parse multiple values and column pairs of a natural language query.

Abstract: The instant disclosure provides antibodies that specifically bind to LAG-3 (e.g., human LAG-3) and antagonize LAG-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A method of controlling a hybrid power unit includes receiving a target total thrust value that is converted into a target speed for a propeller. The target speed is transmitted to a motor speed controller. A sensor value for a current speed for the propeller is received at the motor speed controller. The motor speed controller generates a signal to a primary electric motor to selectively output torque to a rotor and regeneratively brake the rotor according to the target speed. A module current set point based at least in part on a state of charge of a battery is received. A throttle set point is determined based in part on the target speed and the module current set point. A throttle set point of an internal-combustion engine of the hybrid power unit is adjusted based at least in part on the target speed and the module current set point.

Abstract: The present invention provides improved methods for preparing a compound comprising Formula (I).

Abstract: This disclosure includes a manhole cover locking device, system, and kit, each configured for locking a manhole cover in a closed position overtop an access opening of a container, the access opening being arranged at one end of a collar extending outwardly from the container, each comprising: a body; a mechanism for connecting the body to a pre-existing portion of the manhole collar or the container; and, a mechanism for securing the body to the manhole cover to prevent the opening of the manhole cover using a pre-existing portion of the manhole cover. Each mechanism may be tamper resistant. The disclosure also includes methods of installing and using the device, system, and kit.

Abstract: Aspects are described that utilize a distributed network of measurement points to detect sources of lag in a network, but are not so limited. Sources of lag can be detected at particular locations in a network or multiple networks using a plurality of distributed measurement points. Each measurement point can be configured to monitor network conditions at a particular network location using a measurement client to perform a network testing procedure with a measurement stream. Each measurement point can also include a measurement server configured to receive a measurement stream from at least one measurement client. A controller is configured to manage and control one or more of the plurality of measurement clients using a secure connection. Aspects are configured to detect one or more sources of lag of a distributed network of devices and/or cause procedures to be implemented to mitigate identified sources of lag.

Abstract: An example nasal airway tube includes a tubular body having a distal end and a proximal end. A surface at the distal end including an opening. The tubular body having an overall curvature with a radius of curvature defined relative to a longitudinal axis of the tube. An X-axis is defined by the longitudinal axis of the tube, and a Y-axis extends perpendicularly from the longitudinal axis and has a positive direction defined outwardly relative to the radius of curvature. At least a portion of the opening faces outwardly relative to the radius of curvature. A vector normal to a plane defined by the opening includes a positive Y-coordinate.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that identify and issue search queries expected to be issued in the future. A set of search queries that have been issued by multiple user devices can be obtained. For each query instance, contextual data can be obtained. A first query and its contextual data can be input to a model that outputs the query's likelihood of being issued in the future. The model can be trained using contextual data for training queries and a corresponding labels for the training queries. The learning model outputs the first query's likelihood of being issued in future, and this query is stored as a repeatable query if the likelihood satisfying a repeatability threshold. Subsequently, a stored repeatable query is issued upon a selection of a user selectable interface component and the search engine provides search results for the query.

Abstract: Disclosed herein are computer-implemented method, system, and computer-readable storage-medium embodiments for implementing template-based excerpting and rendering of multimedia performances technologies. An embodiment includes at least one computer processor configured to retrieve a first content instance and applying a template that results in transforming the first content instance. The first content instance may include a plurality of structural elements. The first content instance may be transformed by a rendering engine running on the at least one computer processor and/or transmitted to a content-playback device. An embodiment of transforming the first content instance includes trimming the content instance based on requirements provided by social media platforms.

Abstract: The present disclosure provides antibodies and polypeptides that specifically bind to Ig-like transcript 2 (ILT2). Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Techniques for handling natural language query processing are described. In some examples, a sequence-to-sequence model is used to handle a natural language query. Post-processing of a result of the sequence-to-sequence model utilizes fine-grained information from an entity linker. In some examples, the sequence-to-sequence model and aspects of a natural language query pipeline are used to handle a natural language query.

Abstract: An electro-absorption modulator (EAM) is configured to include an on-chip AC ground plane that is used to terminate the high frequency RF input signal within the chip itself. This on-chip ground termination of the modulation input signal improves the frequency response of the EAM, which is an important feature when the EAM needs to support data rates in excess of 50 Gbd. By virtue of using an on-chip ground for the very high frequency signal content, it is possible to use less expensive off-chip components to address the lower frequency range of the data signal (i.e., for frequencies less than about 1 GHz).

Abstract: A spot-size converter includes first and second waveguide structures. The first waveguide structure extends longitudinally along a waveguide axis from a first end to a second end and is configured to support a first optical mode at the first end. The second waveguide structure is formed within the first waveguide structure. The second waveguide structure extends longitudinally between the first end and the second end. The second waveguide structure is configured to support a second optical mode at the second end. The second optical mode has a different diameter than the first optical mode. The second waveguide structure includes a waveguide core that has a first cross-sectional area in a first plane normal to the waveguide axis at the first end and a second cross-sectional area in a second plane normal to the waveguide axis at the second end. The second cross-sectional area is larger than the first cross-sectional area.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The present invention provides improved systems and methods for 3D geometry evaluation using vertex distance from center and mesh triangle vertex distance hashing. The present invention allows the generation of a unique hash that is immune to scale, position, orientation, and being inverted along any axis. This allows for the ability to store a single unique hash for each reference geometry that is calculated in advance, generate the unique hash for a search geometry, and then search for matching hash values. The actual geometries do not have to be stored, and only one string value, the hash value, is being searched.