Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, that identify and issue search queries expected to be issued in the future. A set of search queries that have been issued by multiple user devices can be obtained. For each query instance, contextual data can be obtained. A first query and its contextual data can be input to a model that outputs the query's likelihood of being issued in the future. The model can be trained using contextual data for training queries and a corresponding labels for the training queries. The learning model outputs the first query's likelihood of being issued in future, and this query is stored as a repeatable query if the likelihood satisfying a repeatability threshold. Subsequently, a stored repeatable query is issued upon a selection of a user selectable interface component and the search engine provides search results for the query.

Abstract: Disclosed herein are devices and methods for assessing the surface of a target cardiac tissue and for delivering a tissue anchor to cardiac tissue at a preselected depth within the myocardium in a beating heart procedure. In one variation, an anchor delivery device comprises an elongate body, a tissue anchor disposed within a first longitudinal lumen of the elongate body, and a tissue depth indicator slidable within a second longitudinal lumen of the elongate body. The tissue depth indicator has a first configuration that indicates the boundary of the surface of the target tissue and a second configuration that indicates when the distal tip of the elongate body has been advanced to a preselected depth into the target tissue. In some variations, a tissue depth indicator may also be configured to resist or limit the penetration of the delivery device into tissue after a preselected depth has been reached.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: The present invention relates to a method for identification of common patient-spanning tumor-specific T cell receptors (TCRs) and their corresponding antigens. The invention also relates to these TCR sequences, a nucleic acid encoding the TCR, and a T cell comprising the TCR and/or the encoding nucleic acid.

Abstract: Disclosed herein are computer-implemented method, system, and computer-readable storage-medium embodiments for implementing template-based excerpting and rendering of multimedia performances technologies. An embodiment includes at least one computer processor configured to retrieve a first content instance and applying a template that results in transforming the first content instance. The first content instance may include a plurality of structural elements. The first content instance may be transformed by a rendering engine running on the at least one computer processor and/or transmitted to a content-playback device. An embodiment of transforming the first content instance includes trimming the content instance based on requirements provided by social media platforms.

Abstract: Apparatus for performing group computing in a safety-critical operating environment (SCOE) includes a primary computing device, wherein the primary computing device includes a processor and a memory communicatively connected to the processor. The memory contains instructions configuring the processor to receive task data, determine a group computing need by comparing the task data against a preset group computing criterion, determine a hardware allocation as a function of the group computing need, create a virtual environment using a secondary computing device communicatively connected to the primary computing device, as a function of the hardware allocation, allocate at least a portion of the task data to the at least a secondary computing device, as a function of the group computing need, wherein the at least a portion of the task data is executed by the secondary computing device, and receive from the at least a secondary computing device a processing result.

Abstract: The present invention relates to novel tri-specific binding molecules. The invention also relates to nucleic acids encoding such binding molecules; to methods for preparing such binding molecules; to host cells expressing or capable of expressing such binding molecules; to compositions comprising such binding molecules; and to uses of such binding molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: An exemplary active recirculation system and method for aerosol collection are disclosed that employ recirculation via one or more active pumps (e.g., peristaltic pumps) to continuously circulate a collection buffer within an aerosol collection frontend to improve the collection efficiency. In using less fluid volume, the exemplary active recirculation system and method increase the concentration of the target particle. A high concentration of particles may be advantageous when detecting pathogens downstream of collection. The aerosol collection frontend connects to a collection reservoir. During a collection cycle, a pump draws the fluid from the collection reservoir and pumps the collected fluid back into the collection front end at a set flow rate.

Abstract: The present disclosure provides antibodies and polypeptides that specifically bind to Ig-like transcript 2 (ILT2). Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: Techniques for handling natural language query processing are described. In some examples, a sequence-to-sequence model is used to handle a natural language query. Post-processing of a result of the sequence-to-sequence model utilizes fine-grained information from an entity linker. In some examples, the sequence-to-sequence model and aspects of a natural language query pipeline are used to handle a natural language query.

Abstract: Connections among two different entities are identified by processing a collection of documents to identify one or more documents that contain co-occurring mentions of each of the two different entities. This relationship may be graphically displayed in a user interface with an icon or the like for each of the two entities, along with a graphical link interconnecting the entities. The graphical link can be an active element of the user interface that responds to user interactions by providing access to evidence within the collection of documents that substantiates the connection between the two entities. In one aspect, a search input form field in a user interface may be used to explicitly request documents that substantiate a relationship between two entities. In another aspect, a user may ground entity mentions by explicitly selecting documents that mention an entity of interest.

Abstract: Food supply may be tracked, authenticated, and evaluated by a variety of systems, processes, and techniques. In certain implementations, computer systems at various animal producers in the food supply chain (e.g., ranch and feedlot) may record and generate data regarding an animal (e.g., breed, age, location, hydration regimen, health history, etc.) and report this to a server system, which may process the data in an authenticated manner. Entities further down the chain (e.g., retailers) may access the server system to retrieve information about meat products and use this in sales efforts. Consumers may also retrieve information about meat products so that they may make informed buying decisions. Additionally, feedback may be provided to animal producers regarding the meat, which may encourage them to continue producing quality animals. Data may also be monetized, and a portion reinvested back to the food producer to assist in labor costs associated with system compliance.

Abstract: An electro-absorption modulator (EAM) is configured to include an on-chip AC ground plane that is used to terminate the high frequency RF input signal within the chip itself. This on-chip ground termination of the modulation input signal improves the frequency response of the EAM, which is an important feature when the EAM needs to support data rates in excess of 50 Gbd. By virtue of using an on-chip ground for the very high frequency signal content, it is possible to use less expensive off-chip components to address the lower frequency range of the data signal (i.e., for frequencies less than about 1 GHz).

Abstract: A spot-size converter includes first and second waveguide structures. The first waveguide structure extends longitudinally along a waveguide axis from a first end to a second end and is configured to support a first optical mode at the first end. The second waveguide structure is formed within the first waveguide structure. The second waveguide structure extends longitudinally between the first end and the second end. The second waveguide structure is configured to support a second optical mode at the second end. The second optical mode has a different diameter than the first optical mode. The second waveguide structure includes a waveguide core that has a first cross-sectional area in a first plane normal to the waveguide axis at the first end and a second cross-sectional area in a second plane normal to the waveguide axis at the second end. The second cross-sectional area is larger than the first cross-sectional area.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The present disclosure relates to oxygen-selective anodes and methods for the use thereof.

Abstract: The present invention provides improved systems and methods for 3D geometry evaluation using vertex distance from center and mesh triangle vertex distance hashing. The present invention allows the generation of a unique hash that is immune to scale, position, orientation, and being inverted along any axis. This allows for the ability to store a single unique hash for each reference geometry that is calculated in advance, generate the unique hash for a search geometry, and then search for matching hash values. The actual geometries do not have to be stored, and only one string value, the hash value, is being searched.

Abstract: An intervertebral spacer and stabilization implant includes a plate having sockets configured for retaining a fastener passable through the socket and into an adjacent vertebral body. One or more connecting projections extend from a side of the plate, to mate with projections extending from a spacer body. A plurality of teeth project from at least one of the upper or lower surfaces of the spacer body, and a chamber is formed through the spacer body to enable bone fusion between the vertebrae. The combined plate and spacer may be inserted to lie completely within the intervertebral space, or a portion of the plate may overlie a vertebral body.

Abstract: One variation of a system for generating thrust at an aerial vehicle includes: a primary electric motor; a rotor coupled to the motor; an internal-combustion engine; a disengagement mechanism interposed between the motor and an output shaft of the internal-combustion engine; an cooling shroud defining a shroud inlet between the rotor and the internal-combustion engine, extending over the internal-combustion engine, and defining a cooling shroud outlet opposite the rotor; a cooling fan coupled and configured to displace air through the cooling shroud; and a local controller configured to receive a rotor speed command specifying a target rotor speed, adjust a throttle setpoint of the internal-combustion engine according to the target rotor speed and a state of charge of a battery in the aerial vehicle, and drive the primary electric motor to selectively output torque to the rotor and to regeneratively brake the rotor according to the target rotor speed.