Abstract: A cancer screening method includes changing a compression state of selected tissue; and obtaining a signal indicative of a response of an optical property of the selected tissue in response to the change in the compression state.

Abstract: Evaluating hemodynamic parameters in the cortex can be used as an objective test for CNS activity, e.g., pain.

Abstract: Methods, apparatus (100), and computer program products for determining lifetimes and distribution of fluorophores (102) embedded in samples (104). Fluorophores are placed into the sample, light from a source (110) selected to excite the fluorophores illuminates the sample, light emitted from the excited fluorophores is detected by a device (138), and a time-domain analysis is performed on the detected emitted light to determine a three-dimensional distribution of the fluorophores in the sample.

Abstract: A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a mother's abdomen. Processing is performed to extract absorption information related to fetal arterial blood with calculation of fetal oxygen saturation from the extracted data.

Abstract: A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a mother's abdomen. Processing is performed to extract absorption information related to fetal arterial blood with calculation of fetal oxygen saturation from the extracted data.

Abstract: The invention relates to a method of using diffuse optical tomography and oxygen in a stroke patient, or a patient suspected of having a stroke, to detect ischemic events or bleeds in the brain.

Abstract: The invention features a calibration method for diffuse optical measurements that corrects transmittance measurements between a source and a detector for factors unrelated to sample properties. The calibration method is based on the same set of transmittance measurements that are subsequently corrected by the calibration and used in imaging and/or spectroscopy applications. The calibration method involves a forward calculation for each of multiple source-detector pairs based on an approximate model of the sample, and a minimization of an expression that depends on the forward calculations and the transmittance measurements to determine self-consistent coupling coefficients for every source-detector pair. Once the coupling coefficients have been determined, they can be used to correct the transmittance measurements. If desired, an inverse calculation can be performed on the corrected sample measurements to determine spatial variations in the optical properties of the sample.

Abstract: The invention relates to a method of using diffuse optical tomography and a blood-borne dye in a stroke patient, or a patient suspected of having a stroke, to detect ischemic events or bleeds in the brain.

Abstract: The invention is based on the discovery that indirect, three-dimensional images of features within turbid or dense samples can be reconstructed based on principles of radiative transport to provide higher resolution images than diffuse imaging methods, while enabling penetration depths significantly greater than microscopic imaging methods. The new indirect mode imaging methods enable one to “see” into turbid or dense samples, such as tissue in living animals or humans, ceramics, plastics, liquids, and other materials, to a depth of 50 &mgr;m to 10 mm or more, with higher resolution than diffuse imaging methods.