Patents by Inventor David Alexander Learmonth

David Alexander Learmonth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method For Preparation Of 10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide
    Publication number: 20080139807
    Abstract: A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (1) by ring opening of 11a,10b-dihydro-6H-dibenz/b,f/oxireno[d]azepine-6-carboxamide (5), characterised in that the ring opening is carried out under conditions of elevated pressure.
    Type: Application
    Filed: January 13, 2006
    Publication date: June 12, 2008
    Applicant: PORTELA & C.A.,S.A.
    Inventors: David Alexander Learmonth, Gunter Weingartner, Matthias Kraemer
  • Peripherally-selective inhibitors of dopamine-?-hydroxylase and method of their preparation
    Patent number: 7259271
    Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: August 21, 2007
    Assignee: Portela & C.A., S.A.
    Inventors: David Alexander Learmonth, Patricio Manuel Viera Araújo Soares da Silva, Alexander Beliaev
  • Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5h-dibenz/b, f/azepine-5-carboxamide
    Patent number: 7241886
    Abstract: A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step process involving (i) epoxidation of carbamazepine; (ii) ring-opening of the resulting epoxide and (iii) oxidation of the resulting alcohol
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: July 10, 2007
    Assignee: Portela & C.A., S.A.
    Inventor: David Alexander Learmonth
  • Method for racemization of (S)-(+)- and (R)-(?)-10,11-dihydro-10-hydroxy-5h-dibenz[B,F]azepine-5-carboxamide and optically enriched mixtures thereof
    Patent number: 7189846
    Abstract: A high-yielding method and a useful intermediate, 10-chloro-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (VII) is disclosed. Also disclosed are methods for the racemization of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (I) and (R)-(?)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (II) to racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (III).
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: March 13, 2007
    Assignee: Portela & C.A., S.A.
    Inventor: David Alexander Learmonth
  • Peripherally-selective inhibitors of dopamine-?-hydroxylase and method of their preparation
    Patent number: 7125904
    Abstract: Compounds of formula I: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl or alkylaryl group; X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1, and a method for their preparation. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: October 24, 2006
    Assignee: Portela & C.A., S.A.
    Inventors: David Alexander Learmonth, Patricio Manuel Viera Araújo Soares da Silva, Alexander Beliaev
  • Method for preparation of (s)-(+)-and(r)-(-)10,11-dihydro-10-hydrodoxy-5h-dibenz/b,f/azephine-5-carboxamide
    Patent number: 7119197
    Abstract: An efficient and high-yielding method for the preparation of optically pure (S)-(+) -10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and (R)-(?)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by resolution of racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide using a tartaric acid anhydride.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: October 10, 2006
    Assignee: Portela & C.A., S.A.
    Inventor: David Alexander Learmonth
  • Method for the nitration of phenolic compounds
    Patent number: 7005553
    Abstract: A method for the regioselective ortho-directed nitration of phenolic compounds useful for the preparation of ortho-nitro-phenols according to formula (I) is described.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: February 28, 2006
    Assignee: Portela, C.A., S.A.
    Inventor: David Alexander Learmonth
  • Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-carboxamide and optically enriched mixtures thereof
    Publication number: 20040266754
    Abstract: A high-yielding method and a useful intermediate, 10-chloro-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (VII) is disclosed. Also disclosed are methods for the racemisation of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (I) and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (II) to racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (III).
    Type: Application
    Filed: May 10, 2004
    Publication date: December 30, 2004
    Inventor: David Alexander Learmonth
  • Method for the nitration of phenolic compounds
    Publication number: 20040192961
    Abstract: A method for the regioselective ortho-directed nitration of phenolic compounds useful for the preparation of ortho-nitro-phenols according to formula (I) is described.
    Type: Application
    Filed: May 20, 2004
    Publication date: September 30, 2004
    Inventor: David Alexander Learmonth
  • Method for preparation of (s)-(+)-and(r)-(-)10,11-dihydro-10-hydrodoxy-5h-dibenz/b,f/azephine-5-carboxamide
    Publication number: 20040162280
    Abstract: An efficient and high-yielding method for the preparation of optically pure (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide by resolution of racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide using a tartaric acid anhydride.
    Type: Application
    Filed: April 9, 2004
    Publication date: August 19, 2004
    Inventor: David Alexander Learmonth
  • Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b, f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5h-dibenz/b, f/azepine-5-carboxamide
    Publication number: 20040158060
    Abstract: A method for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-oxo-5H-dibenz/b,f/azepine-5-carboxamide from carbamazepine via a three-step process involving (i) epoxidation of carbamazepine; (ii) ring-opening of the resulting epoxide and (iii) oxidation of the resulting alcohol.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Inventor: David Alexander Learmonth
  • Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation
    Publication number: 20040142996
    Abstract: Compounds of formula I: t,0010
    Type: Application
    Filed: October 8, 2003
    Publication date: July 22, 2004
    Applicant: Portela & C.A., S.A.
    Inventors: David Alexander Learmonth, Patricio Manuel Viera Araujo Soares da Silva, Alexander Beliaev
  • Novel substituted nitrocatechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
    Publication number: 20030060472
    Abstract: New compounds of formula I are described: 1
    Type: Application
    Filed: June 20, 2001
    Publication date: March 27, 2003
    Inventors: David Alexander Learmonth, Patricio Manuel Vieira Araujo Soares da Silva
  • Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
    Patent number: 6512136
    Abstract: New compounds of formula I are described The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders, where a reduction in the O-methylation of catecholamines may be of therapeutical benefit, such as Parkinson's disease and parkinsonian disorders, gastrointestinal disturbances, edema formation states and hypertension.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: January 28, 2003
    Assignee: Portela & C.A., S.A.
    Inventors: Jan Benes, Patricio Manuel Viera Araujo Soares Da Silva, David Alexander Learmonth
  • Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them
    Publication number: 20020037931
    Abstract: New compounds of formula I are described: 1
    Type: Application
    Filed: June 20, 2001
    Publication date: March 28, 2002
    Inventors: David Alexander Learmonth, Patricio Manuel Vierira Araujo Soares da Silva
  • Derivatives of 10, 11-Dihydro-10-OXO-5H-Dibenz/B,F/Azepine-5-carboxamide
    Patent number: 5866566
    Abstract: Compounds of general formula I are described ##STR1## as is a process for their preparation which consists of reacting a compound of formula II ##STR2## with hydroxylamine or its derivatives of formula IIIH.sub.2 NOR.sup.2 (III)The compounds cited in the present invention have valuable pharmaceutical properties namely in the treatment of some disturbances in the central and peripheral nervous system.
    Type: Grant
    Filed: May 23, 1997
    Date of Patent: February 2, 1999
    Assignee: Portela & Ca., S.A.
    Inventors: Jan Benes, Patricio M.V.A. Soares Da Silva, David Alexander Learmonth