Patents by Inventor David Alexander ROSA

David Alexander ROSA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITION FOR KRAS MODIFICATIONS
    Publication number: 20240092756
    Abstract: Provided herein are compounds binding to KRAS protein or a mutant thereof, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
    Type: Application
    Filed: November 18, 2021
    Publication date: March 21, 2024
    Inventors: Patrick T. GUNNING, Jeff OMEARA, Siawash AHMAR, Graham L. SIMPSON, Peter HUNT, David Alexander ROSA, Ji Sung PARK
  • BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
    Publication number: 20240018153
    Abstract: Provided herein are benzenesulfonamide compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
    Type: Application
    Filed: November 18, 2021
    Publication date: January 18, 2024
    Inventors: Patrick T. GUNNING, Jeff OMEARA, Siawash AHMAR, Graham L. SIMPSON, Peter HUNT, David Alexander ROSA, Ji Sung PARK
  • STAT INIHIBITORY COMPOUNDS AND COMPOSITIONS
    Publication number: 20230265055
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer, hematological cancer, and pancreatic cancer.
    Type: Application
    Filed: September 3, 2021
    Publication date: August 24, 2023
    Inventors: Roman FLECK, John PROUDFOOT, Jeff OMEARA, Patrick Thomas GUNNING, Ahmed Magdy ALI, David Alexander ROSA, Angel Sampedro PALERM, Alla DARWISH, Alford Antoine JOHN
  • PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
    Publication number: 20230055961
    Abstract: Provided herein are pentafluorobenzenesulfonamide compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
    Type: Application
    Filed: May 19, 2022
    Publication date: February 23, 2023
    Inventors: Dziyana KRASKOUSKAYA, Siawash AHMAR, Patrick T. GUNNING, Jeff OMEARA, David Alexander ROSA, Ji Sung PARK, Graham L. SIMPSON, Ayah ABDELDAYEM
  • BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
    Publication number: 20220281812
    Abstract: Provided herein are benzenesulfonamide derivatives having Formula (III), pharmaceutical compositions comprising said compounds, and method for using said compounds for disrupting proteins/polypeptides, protein/polypeptide function, and for the treatment of diseases through the disruption of proteins or polypeptides involved in the etiology of the disease. Said compounds comprise fluorinated benzene sulfonamide structures.
    Type: Application
    Filed: July 17, 2020
    Publication date: September 8, 2022
    Inventors: Patrick T. GUNNING, Ji Sung PARK, Siawash AHMAR, Aaron D. CABRAL, Gary K.C. TIN, Sana RASHEED, Ayah ABDELDAYEM, David ARMSTRONG, Geordon A. FRERE, Erica J. QUILATES, David Alexander ROSA, Olga GOZHINA, Jeffrey Alan OMEARA, Graham SIMPSON, Vittoria ZOPPI
  • PENTAFLUOROPHENYL SULFONAMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF
    Publication number: 20200277268
    Abstract: The present application relates to sulfonamide containing compounds of Formulae (I) and (II) and compositions containing said compounds effective in the treatment of cell proliferative disorders, in particular cancer, and various methods of use thereof.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 3, 2020
    Applicant: Dalriada Therapeutics Inc.
    Inventors: Patrick Thomas Gunning, Ji Sung Park, Siawash Ahmar, David Alexander Rosa, Dziyana Kraskouskaya, David Bakhshinyan, Sheila Singh, Chitra Venugopal, Angelika Berger-Becvar, Mulu Geletu-Heye, Mariya Bogatchenko, Elvin De Araujo, Diana Sina
  • HETEROAROMATIC-FUSED IMIDAZOLYL AMIDES, COMPOSITIONS AND USES THEREOF AS STING AGONISTS
    Publication number: 20200031825
    Abstract: Compounds of Formula I and II have been prepared for use in the treatment of diseases, disorders or conditions treatable by activation of the stimulator of interferon genes (STING) adaptor protein, such as in the treatment or prevention of cancers.
    Type: Application
    Filed: October 4, 2019
    Publication date: January 30, 2020
    Applicant: Trillium Therapeutics Inc.
    Inventors: Abdelmalik Slassi, Peter DOVE, Zezhou WANG, Hoi Ying LIN, David Alexander ROSA, Jeffrey Todd WINSTON