Abstract: An addressable radio is described in which the radio has an address that includes (i) a value derived from a counter and (ii) a hash of a combination of the value and an identity-resolving key for the radio device.

Abstract: A method of digital radio communication between a first device 8 and a second device 2, e.g. operating under Bluetooth Low Energy™, is disclosed. Each device 8, 2 comprises a radio transmitter 10, 4 and a radio receiver 12, 6. The method comprises: the first device 8 transmitting a first message 22 to said second 2 device comprising a data value; the second device 8 receiving said first message 22 and determining whether said data value is present; the second device 8 determining a received signal strength associated with said message; the second device comparing said received signal strength to a threshold if it determines that said data value is present; and the second device transmitting a second message 32 to the first device 8 if said received signal strength exceeds said threshold but not transmitting said second message 32 if said received signal strength is below said threshold.

Abstract: A radio communication system comprises a radio transmitter (2), and a radio receiver (12) configured to receive radio transmissions from the transmitter. The transmitter (2) uses a transmitter clock signal to transmit a succession of connection-event data packets (22a?, 22b?, 22c?) according to a predetermined schedule. The receiver (12) enters a sleep state between receiving successive connection-event data packets from the transmitter (2), in which it does not receive and process radio transmissions from the transmitter. It uses a receiver clock signal to determine when a predetermined number of receiver clock cycles has elapsed after receiving one of the connection-event data packets (22b?), and then enters a ready state. The predetermined number of receiver clock cycles is the number of receiver clock cycles (34a) that elapsed between the respective receipts of two of the connection-event data packets (22a?, 22b?) received by the receiver (12) minus a correction factor (38).

Abstract: A method of wireless communication between a master device and a slave device is disclosed. The method comprises: the master device continually transmitting request messages to the slave device; the slave device transmitting reply messages in reply only to some of said request messages; wherein the slave device transmits a reply message in reply to a request message if: a) a predetermined period has elapsed since it transmitted its last reply message; or b) the request message contains data.

Abstract: An interface controller (2) is operated to give one of a plurality of predetermined outputs. An input signal (211) is received and a duration of said input signal is compared with a first and/or second threshold duration. A first output is generated if said input signal duration is shorter than said first threshold duration. A second output is generated if said input signal duration is longer than said first threshold duration but shorter than said second threshold duration. A third output is generated if said input signal duration is longer than said second threshold duration.

Abstract: An addressable radio is described in which the radio has an address that includes (i) a value derived from a counter and (ii) a hash of a combination of the value and an identity-resolving key for the radio device.

Abstract: The present invention relates to a mechanical orthotic that is an aid to walking, which attaches to the foot of the individual receiving treatment and to a mobile partial weight support apparatus, characterized in that it enables the individual to carry out walking and forward movement in just one operation and using the same device. Said device is essentially a mechanical orthotic that moves the foot; the device is attached to the foot of the individual and to the mobile partial weight support apparatus, consisting of a conveyor belt for the foot, from which belt extends a metal shaft with a foot support system at the end of the shaft where the foot will rest. Said conveyor belt is mounted on a matrix in the shape of the trajectory of the foot during walking. The matrix consists of a metal plate fixed to the mobile partial weight support apparatus and a system of bearings that enables the foot conveyor belt to move in order to reduce friction in the system.

Abstract: Secondary packaging for a primary package or product that is at least about 2 times and preferably 2.5 times as high as it is wide. The secondary packaging has a window in the front wall through which the product partially extends. Support for the product is provided by support extensions formed from the side walls in the form of tabs formed integrally from the blank from which the secondary packaging is formed. The product may be secured against rotation by being adhered to an top support tab. The bottom of the window may be reinforced by a tab that is folded inward and against the interior of the front wall in which the window is formed. Side panels may be provided on the left and right sides of the window to provide lateral support to the product and also to reinforce the left and right sides of the window.

Abstract: Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule comprising selecting at least one peptide (II) of 8-11 amino acids (aa), potentially representing an epitope for Class I presentation, from a protein against which a cytotoxic T cell (CTL) response is to be raised. (II) corresponds to a non-immunogenic peptide with low affinity for Class I molecules. Variants (IIa) of (II) are prepared in which the N-terminal aa is replaced by Tyr and their immunogenicity detected by identifying those that generate a CTL response against target cells expressing the parent protein. Peptide sequences from which active (IIa) are derived are then identified.

Abstract: Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule, is new. Identifying subdominant/cryptic epitopes (I) that are presented by a HLA (human leukocyte antigen) Class I molecule comprising selecting at least one peptide (II) of 8-11 amino acids (aa), potentially representing an epitope for Class I presentation, from a protein against which a cytotoxic T cell (CTL) response is to be raised. (II) corresponds to a non-immunogenic peptide with low affinity for Class I molecules. Variants (IIa) of (II) are prepared in which the N-terminal aa is replaced by Tyr and their immunogenicity detected by identifying those that generate a CTL response against target cells expressing the parent protein. Peptide sequences from which active (IIa) are derived are then identified.

Abstract: A pharmaceutical composition comprising CD4+ CD25+ regulatory T cells specific for at least one minor histocompatibility antigen, and stem cells, advantageously haematopoietic, carrying at least the antigen can be used as a medicament for increasing the immune tolerance of a histocompatible host.