Patents by Inventor David Allen Annis

David Allen Annis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF
    Publication number: 20210299211
    Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.
    Type: Application
    Filed: November 6, 2020
    Publication date: September 30, 2021
    Inventors: David Allen Annis, Krzysztof Darlak, Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass
  • Peptidomimetic macrocycles and uses thereof
    Patent number: 11091522
    Abstract: The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: August 17, 2021
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Manuel Aivado, Vincent Guerlavais, Karen Olson, David Allen Annis
  • Peptidomimetic macrocycles and formulations thereof
    Patent number: 10905739
    Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: February 2, 2021
    Assignee: Aileron Therapeutics, Inc.
    Inventors: David Allen Annis, Krzysztof Darlak, Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass
  • Peptidomimetic macrocycles and uses thereof
    Patent number: 10471120
    Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: November 12, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris J. Viau
  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20190269753
    Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 5, 2019
    Inventors: Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris Viau
  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20190256559
    Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.
    Type: Application
    Filed: December 18, 2018
    Publication date: August 22, 2019
    Inventors: Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris Viau
  • Peptidomimetic macrocycles and uses thereof
    Patent number: 10253067
    Abstract: Methods for treating liquid cancer, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a liquid cancer, determined to lack a p53 deactivation mutation, in a subject.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: April 9, 2019
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris Viau
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190071469
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: June 29, 2018
    Publication date: March 7, 2019
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20180339014
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: June 7, 2018
    Publication date: November 29, 2018
    Inventors: Huw M. Nash, David Allen Annis
  • Peptidomimetic macrocycles
    Patent number: 10059741
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: August 28, 2018
    Assignee: Aileron Therapeutics, Inc.
    Inventors: David Allen Annis, Vincent Guerlavais
  • Peptidomimetic macrocycles
    Patent number: 10022422
    Abstract: Novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral diseases are described.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: July 17, 2018
    Assignee: Alleron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170299576
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 6, 2016
    Publication date: October 19, 2017
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20170212125
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 10, 2016
    Publication date: July 27, 2017
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • Peptidomimetic macrocycles with improved properties
    Patent number: 9458202
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: October 4, 2016
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160250278
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: April 7, 2016
    Publication date: September 1, 2016
    Inventors: Huw M. Nash, David Allen Annis
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160251399
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: April 7, 2016
    Publication date: September 1, 2016
    Inventors: Huw M. Nash, David Allen Annis
  • PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
    Publication number: 20160193283
    Abstract: Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.
    Type: Application
    Filed: September 24, 2015
    Publication date: July 7, 2016
    Inventors: Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris J. Viau
  • PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF
    Publication number: 20160101145
    Abstract: Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.
    Type: Application
    Filed: September 24, 2015
    Publication date: April 14, 2016
    Inventors: David Allen Annis, Krzysztof Darlak, Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160096873
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 25, 2015
    Publication date: April 7, 2016
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160068573
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: September 14, 2015
    Publication date: March 10, 2016
    Inventors: Huw M. Nash, David Allen Annis