Patents by Inventor David Allen Hafler

David Allen Hafler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating or preventing Type 1 diabetes by oral administration of insulin
    Patent number: 6703361
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: March 9, 2004
    Assignee: AutoImmune Inc.
    Inventors: Howard L. Weiner, George Eisenbarth, David Allen Hafler, Zhengyi Zhang
  • METHOD OF TREATING OR PREVENTING TYPE 1 DIABETES BY ORAL ADMINISTRATION OF INSULIN
    Publication number: 20010056063
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Application
    Filed: December 2, 1998
    Publication date: December 27, 2001
    Inventors: HOWARD L. WEINER, GEORGE EISENBARTH, DAVID ALLEN HAFLER, ZENGYI ZHANG
  • Method of treating or preventing autoimmune uveoretinitis in mammals
    Patent number: 5961977
    Abstract: The present invention provides a method of treating or preventing the clinical manifestation of an autoimmune disease having the symptoms of uveoretinitis in a mammal in need of such treatment comprising orally administering to said mammal an effective amount of an autoantigen, e.g., S antigen (S-Ag), and/or biologically active fragments, or analogs thereof specific for uveoretinitis.Also provided is a pharmaceutical formulation useful for treating or preventing uveoretinitis in mammals comprising an effective amount of one or more of the foregoing autoantigen, fragments or analogs.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: October 5, 1999
    Assignees: AutoImmune Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: David Allen Hafler, Robert B. Nussenblatt, Alan G. Palestine, Howard L. Weiner
  • Method of treating or preventing type 1 diabetes by oral administration of insulin
    Patent number: 5858968
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 12, 1999
    Assignee: AutoImmune Inc.
    Inventors: Howard L. Weiner, George Eisenberth, David Allen Hafler, Zhengi Zhang
  • Method of treating or preventing Type 1 diabetes by oral administration of insulin
    Patent number: 5843886
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 1, 1998
    Assignee: Autoimmune, Inc.
    Inventors: Howard L. Weiner, George Eisenbarth, David Allen Hafler, Zhengi Zhang
  • Methods and compositions for suppressing allograft rejection in mammals
    Patent number: 5788968
    Abstract: Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 4, 1998
    Assignee: AutoImmune, Inc.
    Inventors: Howard L. Weiner, David Allen Hafler, Charles B. Carpenter, Mohamed Sayegh, Zhengyi Zhang
  • Method of treating or preventing type 1 diabetes by oral administration of insulin
    Patent number: 5763396
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: June 9, 1998
    Assignee: AutoImmune Inc.
    Inventors: Howard L. Weiner, George Eisenberth, David Allen Hafler, Zhengi Zhang
  • Method and compositions for suppressing allograft rejection in mammals
    Patent number: 5681556
    Abstract: Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: October 28, 1997
    Assignee: Autoimmune Inc.
    Inventors: Howard L. Weiner, David Allen Hafler, Charles B. Carpenter, Mohamed Sayegh, Zhengyi Zhang
  • Treatment of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5645820
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: July 8, 1997
    Assignee: AutoImmune, Inc.
    Inventors: David Allen Hafler, Howard L. Weiner
  • Method of treating or preventing type 1 diabetes by oral administration of insulin
    Patent number: 5643868
    Abstract: Disclosed herein are methods for treating or preventing a disease in mammals having the characteristics of Type 1 diabetes comprising administering insulin or disease suppressive fragments of insulin or analogs thereof in oral or aerosol dosage forms to said mammals. Also disclosed herein are pharmaceutical formulation or dosage forms for use in the methods.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 1997
    Assignee: Autoimmune, Inc.
    Inventors: Howard L. Weiner, George Eisenbarth, David Allen Hafler, Zhengyi Zhang
  • Prevention of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5641474
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 24, 1997
    Assignee: AutoImmune, Inc.
    Inventors: David Allen Hafler, Howard L. Weiner
  • Treatment of autoimmune diseases by aerosol administration of autoantigens
    Patent number: 5641473
    Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 24, 1997
    Assignee: AutoImmune, Inc.
    Inventors: David Allen Hafler, Howard L. Weiner