Patents by Inventor David Altshuler

David Altshuler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CFTR-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240093186
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.
    Type: Application
    Filed: September 20, 2023
    Publication date: March 21, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Aamir Mir, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, Robert James Citorik, William Edward Salomon, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • SERPINA-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240084334
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • PAH-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240082429
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.
    Type: Application
    Filed: October 26, 2023
    Publication date: March 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • Propeptide-luciferase fusion proteins and methods of use thereof
    Patent number: 10370697
    Abstract: The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: August 6, 2019
    Assignees: THE BROAD INSTITUE, INC., THE GENERAL HOSPITAL CORPORATION, INSTITUTO CARLOS SLIM DE LA SALUD, A.C.
    Inventors: Sean Burns, David Altshuler, Amedeo Vetere
  • PROPEPTIDE-LUCIFERASE FUSION PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20170260565
    Abstract: The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 14, 2017
    Inventors: SEAN BURNS, DAVID ALTSHULER, AMEDEO VETERE
  • Propeptide-luciferase fusion proteins and methods of use thereof
    Patent number: 9657329
    Abstract: The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: May 23, 2017
    Assignees: The Broad Institute Inc., The General Hospital Corporation, Instituto Carlos slim de la Salud, A.C.
    Inventors: Sean Burns, David Altshuler, Amedeo Vetere
  • PROPEPTIDE-LUCIFERASE FUSION PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20140303035
    Abstract: The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.
    Type: Application
    Filed: November 7, 2012
    Publication date: October 9, 2014
    Inventors: Sean Burns, David Altshuler, Amedeo Vetere
  • IRF-5 haplotypes in systemic lupus erythematosus
    Patent number: 8148074
    Abstract: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: April 3, 2012
    Assignees: Regents of the University of Minnesota, General Hospital Corporation
    Inventors: Timothy W. Behrens, Robert R. Graham, David Altshuler
  • IRF-5 HAPLOTYPES IN SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20100092977
    Abstract: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.
    Type: Application
    Filed: September 23, 2009
    Publication date: April 15, 2010
    Inventors: Timothy W. Behrens, Robert R. Graham, David Altshuler
  • IRF-5 HAPLOTYPES IN SYSTEMIC LUPUS ERYTHEMATOSUS
    Publication number: 20080026386
    Abstract: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.
    Type: Application
    Filed: March 30, 2007
    Publication date: January 31, 2008
    Inventors: Timothy Behrens, Robert Graham, David Altshuler
  • Methods Of Regulating Metabolism And Mitochondrial Function
    Publication number: 20070203083
    Abstract: The invention relates to novel methods of regulating metabolism and mitochondrial biogenesis. Some aspects of the invention relate to methods of treating or preventing diseases in a patient associated with reduced mitochondrial function, to methods of identifying agents to treat such diseases, and to methods of diagnosing such diseases. Other aspects of the invention relate to a set of coordinately-regulated genes which regulate oxidative phosphorylation.
    Type: Application
    Filed: June 14, 2004
    Publication date: August 30, 2007
    Inventors: Vamsi Mootha, David Altshuler
  • Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility
    Publication number: 20070172853
    Abstract: Disclosed herein are methods for predicting the immunocompatibility of two subjects that include determining the presence or absence of one or more deletion variants in the DNA sequence of a gene, where the deletion variant substantially prevents expression of the protein encoded by the gene.
    Type: Application
    Filed: December 4, 2006
    Publication date: July 26, 2007
    Applicant: The General Hospital Corporation
    Inventors: Steven McCarroll, David Altshuler
  • Computer method and apparatus for analyzing mutations in DNA
    Patent number: 6197516
    Abstract: The present invention provides a computer method and apparatus for detecting mutations in DNA fragments. Specifically, percent acetonitrile and threshold temperature, for use in the denaturing high performance liquid chromatography method of separating DNA fragments, are determined. In a preferred embodiment, the present invention serves as a preprocessor to the DHPLC system described in the cited art.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: March 6, 2001
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: David Altshuler, Eric S. Lander