Abstract: Biguanide compounds of formula where R1 comprises a cubanyl-substituted alkyl and R2 comprises a substituted or unsubstituted alkyl, and their use in the treatment of cancers and viral infections are described.

Abstract: In various examples, a technique for monitoring sensor performance is disclosed that includes aggregating sensor data collected by a sensor into a plurality of statistics for a plurality of sectors corresponding to a two-dimensional (2D) plane representing a sensory field of the sensor. The techniques also include determining a performance of the sensor based on the plurality of statistics and historical sensor data or information associated with the sensor. The techniques further include transmitting, to one or more components, one or more indications of the performance of the sensor to cause the one or more components to perform one or more operations in view of or accounting for the performance of the sensor.

Abstract: A grinder/manual defoliation device specifically adapted to separate soft foliage material from all stems and hard material such as seeds and hard plant nodules, including micro stems. The Defoliator has a unique top texture consisting of soft angles and flat surfaces, and a Screen area consisting of angular openings in the screen and a textured surface that when used in conjunction with the top texture together forms a complete defoliation system. Orienting the stems and hard material in a way so they may not pass through the screen, Even though the Defoliator is manually operated the device is operated with ease. It does not employ cutting blades, mulching designs or laser sharpened edges making the device safe for the consumer to use.

Abstract: Systems for analyzing and monitoring deionization tank system performance in a fluid flow system and generating delivery schedules for servicing deionization tanks can include a conductivity sensor and a fluid flow meter. Data regarding the amount and conductivity of fluid flowing through the deionization tank system can be used to predict a remaining capacity of the deionization tank system. A central server can determine the remaining capacity of deionization tank systems at a plurality of service locations. The central server can generate a delivery schedule for servicing deionization tank systems at each of the plurality of service locations based on the determined remaining capacities. Other parameters can be used to optimize efficiency of the delivery schedule while meeting the needs of each of the service locations.

Abstract: Systems for analyzing and monitoring deionization tank system performance in a fluid flow system and generating delivery schedules for servicing deionization tanks can include a conductivity sensor and a fluid flow meter. Data regarding the amount and conductivity of fluid flowing through the deionization tank system can be used to predict a remaining capacity of the deionization tank system. A central server can determine the remaining capacity of deionization tank systems at a plurality of service locations. The central server can generate a delivery schedule for servicing deionization tank systems at each of the plurality of service locations based on the determined remaining capacities. Other parameters can be used to optimize efficiency of the delivery schedule while meeting the needs of each of the service locations.

Abstract: A system and method for time-frequency analysis in which acquired signals are modeled as frictionally damped harmonic oscillators having a friction factor that is not a free parameter are provided. The friction factor is selected as a function of the frequency value of the associated oscillator, such that an increase in both temporal and spectral resolution are provided over existing time-frequency analysis methods. The friction factor is also selected to define a spectral band, within which the given oscillator can detect data oscillations. The properly selected friction factor thereby provides the analysis over a broad spectral range that can span many orders of magnitude.

Abstract: Methods for monitoring scale deposition in a water-containing industrial process are disclosed. In certain embodiments, the water-containing industrial process is an aqueous cooling system. In certain embodiments, the methods incorporate fluorometric monitoring and control techniques along with a piezoelectric microbalance sensor. A particular embodiment of a piezoelectric microbalance sensor is additionally disclosed, along with at least one method for using the particular embodiment that is independent of whether fluorometric monitoring and control techniques are utilized.

Abstract: Methods for monitoring scale deposition in a water-containing industrial process are disclosed. In certain embodiments, the water-containing industrial process is an aqueous cooling system. In certain embodiments, the methods incorporate fluorometric monitoring and control techniques along with a piezoelectric microbalance sensor. A particular embodiment of a piezoelectric microbalance sensor is additionally disclosed, along with at least one method for using the particular embodiment that is independent of whether fluorometric monitoring and control techniques are utilized.

Abstract: A thrust-vectoring nozzle is disclosed that includes a cylindrical case and a flow director. The flow director includes a cylindrical ring having a dimension to fit within the cylindrical case. The cylindrical ring has an inner wall and an outer wall and a plurality of fixed vanes are coupled to the inner wall of the ring. The flow director is configured to rotate about first and second mutually perpendicular axes.

Abstract: A system for draining excess cerebrospinal fluid (CSF) from the head of a subject includes a drainage shunt and a valve assembly that selectively permits the shunt to drain CSF. The valve assembly also compensates for multiple factors that can affect the subject's intracranial pressure (ICP) and compliance, and could otherwise lead to CSF over-drainage or other undesirable conditions.

Abstract: Methods for monitoring scale deposition in a water-containing industrial process are disclosed. In certain embodiments, the water-containing industrial process is an aqueous cooling system. In certain embodiments, the methods incorporate fluorometric monitoring and control techniques along with a piezoelectric microbalance sensor. A particular embodiment of a piezoelectric microbalance sensor is additionally disclosed, along with at least one method for using the particular embodiment that is independent of whether fluorometric monitoring and control techniques are utilized.

Abstract: Methods for monitoring scale deposition in a water-containing industrial process are disclosed. In certain embodiments, the water-containing industrial process is an aqueous cooling system. In certain embodiments, the methods incorporate fluorometric monitoring and control techniques along with a piezoelectric microbalance sensor. A particular embodiment of a piezoelectric microbalance sensor is additionally disclosed, along with at least one method for using the particular embodiment that is independent of whether fluorometric monitoring and control techniques are utilized.

Abstract: A thrust-vectoring nozzle is disclosed that includes a cylindrical case and a flow director. The flow director includes a cylindrical ring having a dimension to fit within the cylindrical case. The cylindrical ring has an inner wall and an outer wall and a plurality of fixed vanes are coupled to the inner wall of the ring. The flow director is configured to rotate about first and second mutually perpendicular axes.

Abstract: A method for identifying, suppressing, and reversing epileptogenesis, which is considered to be a learned response due to brain plasticity. The method includes identifying three epileptogenic conditions, neuronal hyperexcitability, spatial overconnectivity, and temporal overconnectivity. A treatment that accounts for each of these conditions is then be administered to the subject to reverse, or “unlearn,” epilepsy.

Abstract: A system for draining excess cerebrospinal fluid (CSF) from the head of a subject includes a drainage shunt and a valve assembly that selectively permits the shunt to drain CSF. The valve assembly also compensates for multiple factors that can affect the subject's intracranial pressure (ICP) and compliance, and could otherwise lead to CSF over-drainage or other undesirable conditions.

Abstract: A system and method for time-frequency analysis in which acquired signals are modeled as frictionally damped harmonic oscillators having a friction factor that is not a free parameter are provided. The friction factor is selected as a function of the frequency value of the associated oscillator, such that an increase in both temporal and spectral resolution are provided over existing time-frequency analysis methods. The friction factor is also selected to define a spectral band, within which the given oscillator can detect data oscillations. The properly selected friction factor thereby provides the analysis over a broad spectral range that can span many orders of magnitude.

Abstract: A system and method is provided for compensatory invoicing of a patient for health care services rendered by a Health Care Provider. The system and method enables a Health Care Provider to obtain payment of Full Rates for services rendered to a patient in circumstances where a Health Insurance Entity provides less than full-rate compensation (e.g., compensation at Contracted Rates) to the Health Care Provider AND the patient has been reimbursed additionally by another payment party for claims already paid for by the Health Insurance Entity. In one implementation, the patient contracts with the Health Care Provider to ensure that the Health Care Provider is fully compensated for the services rendered after the patient receives payments from a tortfeasor and/or First and/or Third Party Payment Entity (e.g., an auto insurance carrier, worker's compensation insurance carrier, Medpay, PIP etc.) for the services.

Abstract: A method for identifying, suppressing, and reversing epileptogenesis, which is considered to be a learned response due to brain plasticity. The method includes identifying three epileptogenic conditions, neuronal hyperexcitability, spatial overconnectivity, and temporal overconnectivity. A treatment that accounts for each of these conditions is then be administered to the subject to reverse, or “unlearn,” epilepsy.

Abstract: Apparatus and methods for autonomously identifying and mitigating soft-errors affecting integrated circuit memory storage devices are provided. A soft-error mitigation process is invoked upon finding that an integrated circuit memory device is affected by a parity error. In a staged approach, unused memory regions of the integrated circuit memory device are reinitialized; if a redundant deployment prevails, the subsystem corresponding to the affected integrated circuit memory device is reset; memory regions having copies of contents thereof stored at remote locations are rewritten with obtained copies of the contents; and memory regions storing contents which are generated at run-time are reinitialized. Directed parity error scans are employed at each stage. If the parity error persists, one of the apparatus, and the subsystem corresponding to the affected silicon memory device is reset during a maintenance window.

Abstract: A system and method is provided for compensatory invoicing of a patient for health care services rendered by a Health Care Provider. The system and method enables a Health Care Provider to obtain payment of Full Rates for services rendered to a patient in circumstances where a Health Insurance Entity provides less than full-rate compensation (e.g., compensation at Contracted Rates) to the Health Care Provider AND the patient has been reimbursed additionally by another payment party for claims already paid for by the Health Insurance Entity. In one implementation, the patient contracts with the Health Care Provider to ensure that the Health Care Provider is fully compensated for the services rendered after the patient receives payments from a tortfeasor and/or First and/or Third Party Payment Entity (e.g., an auto insurance carrier, worker's compensation insurance carrier, Medpay, PIP etc.) for the services.