Abstract: The present disclosure provides methods and systems for sample preparation and/or analysis. Samples may be cells, or may be derived from one or more cells. Sample preparation may comprise conducting one or more reactions on a target. Such reactions may be conducted in one or more partitions. One or more reactions may be performed in one or more successive operations.

Abstract: Disclosed is a device for simulating the movement of an endoscope in an environment, including: a tube modelling an endoscope tube; and a tracking module including a housing into which the tube is insertable and movable. The tracking module includes a detector of movements of the tube in the housing and a unit for communicating the detected movements to a controller. The controller is configured to generate, at each instant, an image of a portion of an environment based on the movements of the tube detected by the detector so as to simulate the movement of an endoscope in the environment. The tracking module includes a fastener adapted to fasten the tracking module in a releasable manner onto a support.

Abstract: Radio frequency front-end systems with filter reuse. In certain embodiments, a front-end system includes a filter, a low noise amplifier (LNA), and a switch interposed between the filter and an input to the LNA. In a first state of the switch, the filter serves to filter a radio frequency signal that is amplified by the LNA. The front-end system further includes a power amplifier that is coupled to the switch. Additionally, in a second state of the switch, the filter serves to filter an amplified radio frequency transmit signal provided by the power amplifier. Accordingly, a filter along a receive path of the front-end system is reused for transmit.

Abstract: Systems and methods are provided for controlling implementation of network policies in a system including a core network and an open radio access network (O-RAN). The method includes receiving a request for accessing one of multiple network components from an application at a centralized network policy controller. The method additionally includes evaluating the request at the central network policy controller to determine if the request is core related or RAN related and assigning the application to a selected one of the multiple network components based on the evaluation, wherein the selected one is a core component when the request is core-related and the selected one is a RAN component when the request is RAN-related.

Abstract: A system and method including software and any associated hardware components, for use as a medical device to provide a therapeutic treatment where current clinical practices are less accessible and/or less desirable for the user. In one embodiment the therapeutic treatment is a psychological treatment, such as treatment of post-traumatic stress disorder (PTSD) and or phobia(s). In one embodiment, this is a user-directed treatment.

Abstract: An adapter board has an upper moldboard interfacing portion including a rear flat surface, a front surface, and a plurality of retaining spring clip receiving apertures extending from the front surface to the rear flat surface. A lower tool bit attachment portion of the adapter board terminates in a lower adapter board free end defining a bottom surface that defines a plurality of shank receiving bores. Each one of the plurality of shank receiving bores is in communication with one of the plurality of retaining spring clip receiving apertures.

Abstract: The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Rotavirus viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Rotavirus virus infection in a subject using said composition and method of generation.

Abstract: A method for execution by a computing entity includes interpreting a fluid flow response from fluid flow sensors to produce a piston position of a piston associated with a head unit device. The head unit device includes a chamber filled with a shear thickening fluid (STF). The method further includes determining a door position based on the piston position. The method further includes determining parameters for wireless signals based on the door position. The method further includes facilitating utilization of the parameters for the wireless signals to promote successful communication of status and/or control of the door via the wireless signals.

Abstract: A method, computer program product, and computing system for processing historical input/output (IO) performance data associated with one or more storage objects of a storage system. A plurality of IO modeling systems may be trained using the historical IO performance data. Modeling performance information may be determined for the plurality of IO modeling systems across the historical IO performance data. A forecast score may be determined for each IO modeling system based on the modeling performance information for the plurality of IO modeling systems. A subset of the plurality of IO modeling systems may be selected based upon the forecast score for each IO modeling system. The at least one IO modeling system may be trained using the historical IO performance data. IO performance data may be forecasted using the at least one trained IO modeling system from the subset of the plurality of IO modeling systems.

Abstract: Systems and methods include interpreting a first user input from a first user, the first user input comprising a text flow entry, interpreting a second user input from the first user, the second user input comprising at least one of: an in-line data access entry or a table-based calculation entry, positioning a text entry value on a unified document surface in response to the first user input, creating at least one data structure in response to the second user input, the at least one data structure comprising data from an external data source, the external data source being external to the unified document surface, and positioning the at least one data structure on the unified document surface.

Abstract: A system for assembling a vehicular window assembly includes a heating device that, when electrically operated, heats an electrical connector disposed at a glass panel of a vehicular window assembly to heat and melt solder disposed between the electrical connector and an electrically conductive trace established at the glass panel to form a solder joint providing electrically-conductive connection between the electrical connector and the electrically conductive trace established at the glass panel. A temperature sensor captures sensor data indicative of a temperature of the electrical connector and the solder. The system, based on processing at an electronic control unit (ECU) of the captured sensor data, adjusts electrical operation of the heating device to adjust the temperature of the electrical connector and the solder during the soldering process that forms the solder joint.

Abstract: The present invention relates to a weatherproof ashtray device having an improved ashtray concealed within a deck post cap. The cap is adapted to be placed on a top end of a deck post and configured to receive the tray or ashtray. The cap has a hinged cover that can be pivotally opened to access the ashtray for use. The ashtray remains secured inside the cap thereby eliminating risk of being knocked off. Further, the cover protects the ashtray from weather elements. The ashtray device enables the deck post to function as normal while offering a place for individuals to discreetly smoke and dispose of their ashes, cigarette butts, and cigar butts. The cap and ashtray are weatherproof to prevent damage due to wind, rain, snow, and other inclement weather.

Abstract: Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule.

Abstract: Provided herein are, inter alia, antibodies capable of binding Structural Maintenance of Chromosome-1 (SMC1). The antibodies provided herein include novel light chain and heavy chain sequences and bind SMC1 (e.g., SMC1A or SMC1B) with high efficiency and specificity. The SMC1 antibodies provided herein including embodiments thereof may be used for diagnostic and therapeutic purposes, for example, as humanized SMC1 antibodies, antibody drug conjugates or they may form part of bispecific antibodies or chimeric antigen receptors.

Abstract: A printed film RF micros trip bandpass filter includes a plurality of resonators disposed on a dielectric substrate, first and second input/output (I/O) interfaces connected to corresponding first and second resonators flanking one or more intermediate resonators. Opposite ends of the one or more intermediate resonators are connected to a ground plane on an opposite side of the substrate by corresponding conductors. The intermediate resonators have an electrical wavelength that is one-half a wavelength of a center frequency of the filter and the first and second resonators can have an electrical wavelength that is nominally one-half the wavelength of the bandpass filter center frequency.

Abstract: An apparatus for and a method of a coaxial-to-waveguide power combiner/divider. The apparatus includes a single-fin coaxial-to-waveguide power combiner/divider, including a waveguide having one open end, one closed end, and two sides that are broader than two other sides; two fins in a plane within the waveguide, wherein the plane is configured to be parallel to the broader sides of the waveguide; and at least one coaxial input joined to each of the two fins. Signals may be applied to the at least one coaxial input joined to each of the two fins are in phase with each other, and a number of the at least one coaxial input joined to each of the two fins may include one of a same number and a different number.

Abstract: A computer-implemented method for quality measurement for videoconferencing may include (i) measuring the interaction levels of a plurality of video conference attendees in a group video conference, (ii) designating, based at least in part on the interaction levels, a current dominant speaker in the group video conference, (iii) calculating a video conference quality level for the current dominant speaker in the group video conference, and (iv) providing the video conference quality level for the current dominant speaker as the video conference quality level for the group video conference. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: An ASR model includes a first encoder configured to receive a sequence of acoustic frames and generate a first higher order feature representation for a corresponding acoustic frame in the sequence of acoustic frames. The ASR model also includes a second encoder configured to receive the first higher order feature representation generated by the first encoder at each of the plurality of output steps and generate a second higher order feature representation for a corresponding first higher order feature frame. The ASR model also includes a decoder configured to receive the second higher order feature representation generated by the second encoder at each of the plurality of output steps and generate a first probability distribution over possible speech recognition hypothesis. The ASR model also includes a language model configured to receive the first probability distribution over possible speech hypothesis and generate a rescored probability distribution.

Abstract: A retrograde intramedullary nail for insertion in the medullary canal of a femur includes a body that is elongate and defines a leading end and a trailing end spaced from each other at a length sufficient to extend from an intercondylar region at least to a subtrochanteric region of the femur. The body further defines a leading portion that extends to the leading end. The leading portion defines at least one locking hole configured to receive a fixation member. The at least one locking hole defines a central hole axis that is oriented to extend through the neck and head of the femur.